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1. Symposium review: The choice and collection of new relevant phenotypes for fertility selection

Author:
Miglior, F.,   et al.   ; Fleming, A.; Baes, C.F.; Martin, A.A.A.; Chud, T.C.S.; Malchiodi, F.; Brito, L.F.;     Show all 7 Authors
Source:
Journal of dairy science 2019 v.102 no.4 pp. 3722-3734
ISSN:
0022-0302
Subject:
artificial insemination; body condition; calving; corpus luteum; dairy cows; estrus; female fertility; fetal death; genetic improvement; heat; herds; industry; insemination; longevity; milk; milk production; natural selection; periodicity; phenotype; pregnancy; profitability; reproductive efficiency; selection index
Abstract:
... In dairy production, high fertility contributes to herd profitability by achieving greater production and maintaining short calving intervals. Improved management practices and genetic selection have contributed to reversing negative trends in dairy cow fertility, but further progress is still required. Phenotypes included in current genetic evaluations are largely interval and binary traits calcu ...
DOI:
10.3168/jds.2018-15470

2. Genetics and genomics of reproductive disorders in Canadian Holstein cattle

Author:
Miglior, F.,   et al.   ; Guarini, A.R.; Lourenco, D.A.L.; Brito, L.F.; Sargolzaei, M.; Baes, C.F.; Misztal, I.; Schenkel, F.S.;     Show all 8 Authors
Source:
Journal of dairy science 2019 v.102 no.2 pp. 1341-1353
ISSN:
0022-0302
Subject:
Holstein; animal ovaries; cattle diseases; dairy cattle; endometritis; genes; genetic correlation; genetic variation; genome-wide association study; genomics; herds; heritability; linear models; ovarian cysts; phenotype; profitability; retained placenta; sires; standard deviation; Canada
Abstract:
... In Canada, reproductive disorders known to affect the profitability of dairy cattle herds have been recorded by producers on a voluntary basis since 2007. Previous studies have shown the feasibility of using producer-recorded health data for genetic evaluations. Despite low heritability estimates and limited availability of phenotypic information, sufficient genetic variation has been observed for ...
DOI:
10.3168/jds.2018-15038

3. Candidate gene association analyses for ketosis resistance in Holsteins

Author:
Miglior, F.,   et al.   ; Kroezen, V.; Schenkel, F.S.; Baes, C.F.; Squires, E.J.;     Show all 5 Authors
Source:
Journal of dairy science 2018 v.101 no.6 pp. 5240-5249
ISSN:
0022-0302
Subject:
Holstein; breeding; cows; dairy cattle; disease resistance; fatty acids; genes; genetic markers; genotyping; gluconeogenesis; inheritance (genetics); ketone bodies; ketosis; milk production; models; pathogenesis; proteins; quantitative trait loci; single nucleotide polymorphism; tricarboxylic acid cycle
Abstract:
... High-yielding dairy cattle are susceptible to ketosis, a metabolic disease that negatively affects the health, fertility, and milk production of the cow. Interest in breeding for more robust dairy cattle with improved resistance to disease is global; however, genetic evaluations for ketosis would benefit from the additional information provided by genetic markers. Candidate genes that are proposed ...
DOI:
10.3168/jds.2017-13374

4. Symposium review: Novel strategies to genetically improve mastitis resistance in dairy cattle

Author:
Miglior, F.,   et al.   ; Martin, P.; Barkema, H.W.; Brito, L.F.; Narayana, S.G.;     Show all 5 Authors
Source:
Journal of dairy science 2018 v.101 no.3 pp. 2724-2736
ISSN:
0022-0302
Subject:
animal welfare; bacteriology; bovine mastitis; breeding; dairy cattle; dairy industry; data collection; disease resistance; early lactation; farms; females; genetic background; genetic correlation; genomics; longevity; milk yield; models; natural selection; phenotype; profitability; somatic cell count; somatic cells; standard deviation; udders
Abstract:
... Mastitis is a disease of major economic importance to the dairy cattle sector because of the high incidence of clinical mastitis and prevalence of subclinical mastitis and, consequently, the costs associated with treatment, production losses, and reduced animal welfare. Disease-recording systems compiling data from a large number of farms are still not widely implemented around the world; thus, se ...
DOI:
10.3168/jds.2017-13554

5. Genome-wide association analysis for β-hydroxybutyrate concentration in Milk in Holstein dairy cattle

Author:
Miglior, F.,   et al.   ; Nayeri, S.; Schenkel, F.; Fleming, A.; Kroezen, V.; Sargolzaei, M.; Baes, C.; Cánovas, A.; Squires, J.;     Show all 9 Authors
Source:
BMC genetics 2019 v.20 no.1 pp. 58
ISSN:
1471-2156
Subject:
3-hydroxybutyric acid; Holstein; Jersey; dairy cows; farmers; farms; genome-wide association study; genomics; immune response; inflammation; ketone bodies; ketosis; lactation; lipid metabolism; mastitis; milk; milk composition; morbidity; regulator genes; single nucleotide polymorphism; spectroscopy
Abstract:
... BACKGROUND: Ketosis in dairy cattle has been shown to cause a high morbidity in the farm and substantial financial losses to dairy farmers. Ketosis symptoms, however, are difficult to identify, therefore, the amount of ketone bodies (mainly β-hydroxybutyric acid, BHB) is used as an indicator of subclinical ketosis in cows. It has also been shown that milk BHB concentrations have a strong correlati ...
DOI:
10.1186/s12863-019-0761-9

6. Use of a single-step approach for integrating foreign information into national genomic evaluation in Holstein cattle

Author:
Miglior, F.,   et al.   ; Guarini, A.R.; Lourenco, D.A.L.; Brito, L.F.; Sargolzaei, M.; Baes, C.F.; Tsuruta, S.; Misztal, I.; Schenkel, F.S.;     Show all 9 Authors
Source:
Journal of dairy science 2019 v.102 no.9 pp. 8175-8183
ISSN:
0022-0302
Subject:
Holstein; breeding programs; breeding value; bulls; genomics; genotyping; milking; pedigree; phenotype; prediction; temperament
Abstract:
... The use of multi-trait across-country evaluation (MACE) and the exchange of genomic information among countries allows national breeding programs to combine foreign and national data to increase the size of the training populations and potentially increase accuracy of genomic prediction of breeding values. By including genotyped and nongenotyped animals simultaneously in the evaluation, the single ...
DOI:
10.3168/jds.2018-15819

7. Estimating the effect of the deleterious recessive haplotypes AH1 and AH2 on reproduction performance of Ayrshire cattle

Author:
Miglior, F.,   et al.   ; Guarini, A.R.; Sargolzaei, M.; Brito, L.F.; Kroezen, V.; Lourenco, D.A.L.; Baes, C.F.; Cole, J.B.; Schenkel, F.S.;     Show all 9 Authors
Source:
Journal of dairy science 2019 v.102 no.6 pp. 5315-5322
ISSN:
0022-0302
Subject:
Ayrshire (cattle breed); bulls; carrier state; cows; dairy industry; dams (mothers); fetal death; genotyping; haplotypes; heifers; mating behavior; models; parity (reproduction); phenotype; reproductive performance; reproductive traits; sires
Abstract:
... The effects of 2 deleterious recessive haplotypes on reproduction performance of Ayrshire cattle, Ayrshire Haplotype 1 (AH1) and Ayrshire Haplotype 2 (AH2), were investigated in Canadian Ayrshire cattle. We calculated their phenotypic effects on stillbirth (SB) rate and 56-d nonreturn rate (NRR) by estimating the interaction of service sire carrier status with maternal grandsire carrier status usi ...
DOI:
10.3168/jds.2018-15366

8. Invited review: Determination of large-scale individual dry matter intake phenotypes in dairy cattle

Author:
Miglior, F.,   et al.   ; Seymour, D.J.; Cánovas, A.; Baes, C.F.; Chud, T.C.S.; Osborne, V.R.; Cant, J.P.; Brito, L.F.; Gredler-Grandl, B.; Finocchiaro, R.; Veerkamp, R.F.; de Haas, Y.;     Show all 12 Authors
Source:
Journal of dairy science 2019 v.102 no.9 pp. 7655-7663
ISSN:
0022-0302
Subject:
breeding; capital; dairy cattle; dairy science; dry matter intake; feed conversion; feeds; genetic analysis; herds; labor; milk; models; phenotype; spectral analysis; systematic review
Abstract:
... Feed efficiency has been widely studied in many areas of dairy science and is currently seeing renewed interest in the field of breeding and genetics. A critical part of determining how efficiently an animal utilizes feed is accurately measuring individual dry matter (DM) intake. Currently, multiple methods are used to measure feed intake or determine the DM content of that feed, resulting in diff ...
DOI:
10.3168/jds.2019-16454

9. Implementation of Bayesian methods to identify SNP and haplotype regions with transmission ratio distortion across the whole genome: TRDscan v.1.0

Author:
Miglior, F.,   et al.   ; Id-Lahoucine, S.; Cánovas, A.; Jaton, C.; Fonseca, P.A.S.; Sargolzaei, M.; Miller, S.; Schenkel, F.S.; Medrano, J.F.; Casellas, J.;     Show all 10 Authors
Source:
Journal of dairy science 2019 v.102 no.4 pp. 3175-3188
ISSN:
0022-0302
Subject:
Bayesian theory; Holstein; Mendelian inheritance; alleles; computer software; data collection; fetus; germ cells; haplotypes; heterozygosity; livestock; loci; models; parents; progeny; single nucleotide polymorphism
Abstract:
... Realized deviations from the expected Mendelian inheritance of alleles from heterozygous parents have been previously reported in a broad range of organisms (i.e., transmission ratio distortion; TRD). Various biological mechanisms affecting gametes, embryos, fetuses, or even postnatal offspring can produce patterns of TRD. However, knowledge about its prevalence and potential causes in livestock s ...
DOI:
10.3168/jds.2018-15296

10. A landscape of the heritability of Fourier-transform infrared spectral wavelengths of milk samples by parity and lactation stage in Holstein cows

Author:
Miglior, F.,   et al.   ; Rovere, G.; de los Campos, G.; Tempelman, R.J.; Vazquez, A.I.; Schenkel, F.; Cecchinato, A.; Bittante, G.; Toledo-Alvarado, H.; Fleming, A.;     Show all 10 Authors
Source:
Journal of dairy science 2019 v.102 no.2 pp. 1354-1363
ISSN:
0022-0302
Subject:
Fourier transform infrared spectroscopy; Holstein; absorption; cows; energy; heritability; lactation stage; landscapes; metabolites; milk; parity (reproduction); spectral analysis; variance; wavelengths
Abstract:
... Fourier-transform near- and mid-infrared (FTIR) milk spectral data are routinely collected in many countries worldwide. Establishing an optimal strategy to use spectral data in genetic evaluations requires knowledge of the heritabilities of individual FTIR wavelength absorbances. Previous FTIR heritability estimates have been based on relatively small sample sizes and have not considered the possi ...
DOI:
10.3168/jds.2018-15109
CHORUS:
10.3168/jds.2018-15109

11. Comparison of genomic predictions for lowly heritable traits using multi-step and single-step genomic best linear unbiased predictor in Holstein cattle

Author:
Miglior, F.,   et al.   ; Guarini, A.R.; Lourenco, D.A.L.; Brito, L.F.; Sargolzaei, M.; Baes, C.F.; Misztal, I.; Schenkel, F.S.;     Show all 8 Authors
Source:
Journal of dairy science 2018 v.101 no.9 pp. 8076-8086
ISSN:
0022-0302
Subject:
Holstein; breeding programs; bulls; cows; genetic traits; genomics; genotype; genotyping; heritability; mixing; pedigree; phenotype; prediction; regression analysis
Abstract:
... The success and sustainability of a breeding program incorporating genomic information is largely dependent on the accuracy of predictions. For low heritability traits, large training populations are required to achieve high accuracies of genomic estimated breeding values (GEBV). By including genotyped and nongenotyped animals simultaneously in the evaluation, the single-step genomic BLUP (ssGBLUP ...
DOI:
10.3168/jds.2017-14193

12. Genome-wide association study and in silico functional analysis of the number of embryos produced by Holstein donors

Author:
Miglior, F.,   et al.   ; Jaton, C.; Schenkel, F.S.; Sargolzaei, M.; Cánova, A.; Malchiodi, F.; Price, C.A.; Baes, C.;     Show all 8 Authors
Source:
Journal of dairy science 2018 v.101 no.8 pp. 7248-7257
ISSN:
0022-0302
Subject:
Holstein; animal models; animals; breeding value; chromosomes; data collection; females; genes; genome-wide association study; genotyping; in vitro fertilization; ova; quality control; single nucleotide polymorphism; sires; superovulation; Canada
Abstract:
... Superovulation or ovum pick-up and in vitro fertilization are technologies used to produce an increased number of embryos from elite females. Embryo production traits have been shown to be heritable, but the genes that cause this variability have not yet been assessed. The main objectives of this study were to perform a genome-wide association study (GWAS) to find single nucleotide polymorphisms ( ...
DOI:
10.3168/jds.2017-13848

13. Comparison of Bayesian regression models and partial least squares regression for the development of infrared prediction equations

Author:
Miglior, F.,   et al.   ; Bonfatti, V.; Tiezzi, F.; Carnier, P.;     Show all 4 Authors
Source:
Journal of dairy science 2017 v.100 no.9 pp. 7306-7319
ISSN:
0022-0302
Subject:
alphaS2-casein; calcium; coagulation; equations; fatty acid composition; fatty acids; kappa-casein; lactalbumin; lactoferrin; least squares; magnesium; models; pH; potassium; prediction; protein composition
Abstract:
... The objective of this study was to compare the prediction accuracy of 92 infrared prediction equations obtained by different statistical approaches. The predicted traits included fatty acid composition (n = 1,040); detailed protein composition (n = 1,137); lactoferrin (n = 558); pH and coagulation properties (n = 1,296); curd yield and composition obtained by a micro-cheese making procedure (n = 1 ...
DOI:
10.3168/jds.2016-12203

14. Short communication: Recursive model approach to traits defined as ratios: Genetic parameters and breeding values

Author:
Miglior, F.,   et al.   ; Jamrozik, J.; Johnston, J.; Sullivan, P.G.;     Show all 4 Authors
Source:
Journal of dairy science 2017 v.100 no.5 pp. 3767-3772
ISSN:
0022-0302
Subject:
breeding value; methodology; milk fat; milk yield; models; phenotype
Abstract:
... A novel method for analysis of ratio traits (Y2/Y1) is proposed. Utilizing a recursive modeling approach, a proxy for Y2/Y1 can be postulated as Y2 – λ × Y1 (i.e., Y2 adjusted for the effect of Y1), where λ is a structural parameter describing an effect of change in phenotype of Y2 caused by the phenotype of Y1. Estimates of parameters (direct effect parameters) for the recursive model Y1 → Y2 can ...
DOI:
10.3168/jds.2016-12177

15. Standardization of milk infrared spectra for the retroactive application of calibration models

Author:
Miglior, F.,   et al.   ; Bonfatti, V.; Fleming, A.; Koeck, A.;     Show all 4 Authors
Source:
Journal of dairy science 2017 v.100 no.3 pp. 2032-2041
ISSN:
0022-0302
Subject:
absorbance; databases; equations; milk; milk composition; models; prediction; principal component analysis; saturated fatty acids; short chain fatty acids; spectral analysis; Canada
Abstract:
... The objective of this study was to standardize the infrared spectra obtained over time and across 2 milk laboratories of Canada to create a uniform historical database and allow (1) the retroactive application of calibration models for prediction of fine milk composition; and (2) the direct use of spectral information for the development of indicators of animal health and efficiency. Spectral vari ...
DOI:
10.3168/jds.2016-11837

16. The genetic architecture of milk ELISA scores as an indicator of Johne's disease (paratuberculosis) in dairy cattle

Author:
Miglior, F.,   et al.   ; Brito, Luiz F.; Mallikarjunappa, S.; Sargolzaei, M.; Koeck, A.; Chesnais, J.; Schenkel, F.S.; Meade, K.G.; Karrow, N.A.;     Show all 9 Authors
Source:
Journal of dairy science 2018 v.101 no.11 pp. 10062-10075
ISSN:
0022-0302
Subject:
Holstein; Mycobacterium avium subsp. paratuberculosis; absorbance; animal models; antibodies; dairy cattle; dairy herds; data collection; enzyme-linked immunosorbent assay; genes; genome-wide association study; genomics; herd improvement; heritability; homeostasis; immune response; milk; paratuberculosis; single nucleotide polymorphism; variance
Abstract:
... Johne's disease (or paratuberculosis), caused by Mycobacterium avium ssp. paratuberculosis (MAP) infection, is a globally prevalent disease with severe economic and welfare implications. With no effective treatment available, understanding the role of genetics influencing host infection status is essential to develop selection strategies to breed for increased resistance to MAP infection. The main ...
DOI:
10.3168/jds.2017-14250

17. Phenotypic investigation of fine milk components in bovine milk and their prediction using mid-infrared spectroscopy

Author:
Miglior, F.,   et al.   ; Fleming, A.; Schenkel, F.S.; Ali, R.A.; Corredig, M.; Carta, S.; Gregu, C.M.; Malchiodi, F.; Macciotta, N.P.P.;     Show all 9 Authors
Source:
Canadian journal of animal science 2018 v.99 no.2 pp. 218-227
ISSN:
1918-1825
Subject:
Fourier transform infrared spectroscopy; calcium; casein; dairy cows; equations; herds; lactation; lactoferrin; least squares; micelles; milk; milk production; models; phenotype; phenotypic variation; prediction; somatic cells
Abstract:
... This study aimed to examine the phenotypic variation observed in fine milk components, the use of mid-infrared (MIR) spectroscopy to predict these components, and the correlations with other milk production traits. A total of 4116 milk samples were collected from 414 dairy cows from 44 Canadian herds. Overall 3117 samples were analyzed for casein micelle size, 986 and 937 for total and soluble cal ...
DOI:
10.1139/cjas-2018-0058

18. Genetic correlations of mid-infrared-predicted milk fatty acid groups with milk production traits

Author:
Miglior, F.,   et al.   ; Fleming, A.; Schenkel, F.S.; Malchiodi, F.; Ali, R.A.; Mallard, B.; Sargolzaei, M.; Jamrozik, J.; Johnston, J.;     Show all 9 Authors
Source:
Journal of dairy science 2018 v.101 no.5 pp. 4295-4306
ISSN:
0022-0302
Subject:
Holstein; breeding; cows; genetic correlation; herds; lactation; milk; milk fatty acids; milk yield; models; parity (reproduction); saturated fatty acids; short chain fatty acids; somatic cells; spectral analysis; statistical analysis
Abstract:
... The objective of this research was to estimate the genetic correlations between milk mid-infrared-predicted fatty acid groups and production traits in first-parity Canadian Holsteins. Contents of short-chain, medium-chain, long-chain, saturated, and unsaturated fatty acid groupings in milk samples can be predicted using mid-infrared spectral data for cows enrolled in milk recording programs. Predi ...
DOI:
10.3168/jds.2017-14089

19. Multiple-trait estimates of genetic parameters for metabolic disease traits, fertility disorders, and their predictors in Canadian Holsteins

Author:
Miglior, F.,   et al.   ; Jamrozik, J.; Koeck, A.; Kistemaker, G.J.;     Show all 4 Authors
Source:
Journal of dairy science 2016 v.99 no.3 pp. 1990-1998
ISSN:
0022-0302
Subject:
3-hydroxybutyric acid; Holstein; body condition; correlation; cows; disease incidence; displaced abomasum; endometritis; genetic background; genetic correlation; heritability; ketosis; lactation; linear models; milk; retained placenta; variance
Abstract:
... Producer-recorded health data for metabolic disease traits and fertility disorders on 35,575 Canadian Holstein cows were jointly analyzed with selected indicator traits. Metabolic diseases included clinical ketosis (KET) and displaced abomasum (DA); fertility disorders were metritis (MET) and retained placenta (RP); and disease indicators were fat-to-protein ratio, milk β-hydroxybutyrate, and body ...
DOI:
10.3168/jds.2015-10505

20. Short communication: Prevalence of digital dermatitis in Canadian dairy cattle classified as high, average, or low antibody- and cell-mediated immune responders

Author:
Miglior, F.,   et al.   ; Cartwright, S.L.; Malchiodi, F.; Thompson-Crispi, K.; Mallard, B.A.;     Show all 5 Authors
Source:
Journal of dairy science 2017 v.100 no.10 pp. 8409-8413
ISSN:
0022-0302
Subject:
animal welfare; computer software; cows; dairy cattle; dairy farming; dairy herds; data analysis; dermatitis; disease incidence; farms; hooves; immune response; lactation; lameness; linear models; pregnancy; Ontario
Abstract:
... Lameness is a major animal welfare issue affecting Canadian dairy producers, and it can lead to production, reproduction, and health problems in dairy cattle herds. Although several different lesions affect dairy cattle hooves, studies show that digital dermatitis is the most common lesion identified in Canadian dairy herds. It has also been shown that dairy cattle classified as having high immune ...
DOI:
10.3168/jds.2016-12157