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- Moghaddam Panah, Fatemeh, et al. Show all 4 Authors
- International journal of biological macromolecules 2019 v.125 pp. 785-790
- P-glycoproteins; brain; chitosan; drug delivery systems; hydrogels; intravenous injection; methotrexate; nanoparticles; rats; verapamil; zeta potential
- ... Chitosan-based hydrogel nanoparticles provide a higher brain concentration of methotrexate (MTX) following IV administration in comparison with the drug's simple solution. The present study investigates the mechanism of this phenomenon, focusing on the possible role of P-gp. A previously developed MTX containing chitosan nanogel was fabricated and characterised. Then 48 rats were divided into four ...