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- Monaco, Zoia L., et al. Show all 2 Author
- Chromosome research 2015 v.23 no.1 pp. 105-110
- DNA; cell membranes; centromeres; chromatin; embryonic stem cells; gene expression; harvesting; humans; metaphase; mice; models; neoplasm cells; neurons; regulator genes; satellite DNA
- ... De novo artificial chromosomes expressing genes have been generated in human embryonic stem cells (hESc) and are maintained following differentiation into other cell types. Human artificial chromosomes (HAC) are small, functional, extrachromosomal elements, which behave as normal chromosomes in human cells. De novo HAC are generated following delivery of alpha satellite DNA into target cells. HAC ...
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