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- Morrison, Helen, et al. Show all 16 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.51 pp. 20587-20592
- humans; microfilament proteins; mitogen-activated protein kinase; rats; receptor protein-tyrosine kinase; recombinant proteins; sarcoma; signal transduction
- ... Receptor tyrosine kinases participate in several signaling pathways through small G proteins such as Ras (rat sarcoma). An important component in the activation of these G proteins is Son of sevenless (SOS), which catalyzes the nucleotide exchange on Ras. For optimal activity, a second Ras molecule acts as an allosteric activator by binding to a second Ras-binding site within SOS. This allosteric ...
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