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- Muñoz-Escobar, Juliana, et al. Show all 9 Authors
- Biochemical and biophysical research communications 2018 v.495 no.1 pp. 1002-1007
- Legionella pneumophila; Legionnaires' disease; crystal structure; dimerization; germplasm conservation; humans; pathogens; pneumonia; ultracentrifugation
- ... Legionella pneumophila is a pathogen, causing severe pneumonia in humans called Legionnaires' disease. AnkC (LegA12) is a poorly characterized 495-residue effector protein conserved in multiple Legionella species. Here, we report the crystal structure of a C-terminally truncated AnkC (2–384) at 3.2 Å resolution. The structure shows seven ankyrin repeats (ARs) with unique structural features. AnkC ...