Jump to Main Content
- Nédélec, Yohann, et al. Show all 8 Authors
- Genome biology 2016 v.17 no.1 pp. 246
- ancestry; enzymes; genes; haplotypes; human population; humans; innate immunity; introgression; loci; people; transcription (genetics); Africa
- ... BACKGROUND: The 2’-5’ oligoadenylate synthetase (OAS) locus encodes for three OAS enzymes (OAS1-3) involved in innate immune response. This region harbors high amounts of Neandertal ancestry in non-African populations; yet, strong evidence of positive selection in the OAS region is still lacking. RESULTS: Here we used a broad array of selection tests in concert with neutral coalescent simulations ...
- PubMed Central:
- Nédélec, Yohann, et al. Show all 18 Authors
- Cell 2016 v.167 pp. 657-669.e21
- ancestry; genetic variation; humans; immune response; inflammation; macrophages; microbial growth; natural selection; pathogens; phenotypic variation; quantitative trait loci; regulator genes; transcription (genetics); Africa; Europe
- ... Individuals from different populations vary considerably in their susceptibility to immune-related diseases. To understand how genetic variation and natural selection contribute to these differences, we tested for the effects of African versus European ancestry on the transcriptional response of primary macrophages to live bacterial pathogens. A total of 9.3% of macrophage-expressed genes show anc ...
- Nédélec, Yohann, et al. Show all 14 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.35 pp. E3596
- Europeans; body size; genes; haplotypes; humans; phenotype; single nucleotide polymorphism; somatotropin receptors; tropical rain forests; Cameroon; Gabon; Uganda
- ... The evolutionary history of the human pygmy phenotype (small body size), a characteristic of African and Southeast Asian rainforest hunter-gatherers, is largely unknown. Here we use a genome-wide admixture mapping analysis to identify 16 genomic regions that are significantly associated with the pygmy phenotype in the Batwa, a rainforest hunter-gatherer population from Uganda (east central Africa) ...
- PubMed Central: