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- Naderi, Maloos, et al. Show all 6 Authors
- Biological trace element research 2017 v.179 no.1 pp. 102-109
- alanine transaminase; antioxidant activity; aspartate transaminase; blood serum; feed supplements; glutathione; hepatotoxicity; histology; lipid peroxidation; liver; nutrient deficiencies; oxidation; oxidative stress; protective effect; rats; selenium; valproic acid; zinc
- ... Valproic acid (VPA) is an antiepileptic drug, which its usage is limited due to its hepatotoxicity. The present study was conducted to investigate the efficacy of zinc (Zn) and selenium (Se), necessary trace elements, against VPA-induced hepatotoxicity in Wistar rats. The animals were divided into five groups: control, VPA 200 mg/kg, VPA + Zn (100 mg/kg), VPA + Se (100 mg/kg), and VPA + Zn + Se. T ...