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- Nakaya, Tomohiro, et al. Show all 7 Authors
- Biochemistry 2012 v.51 no.16 pp. 3342-3348
- DNA; aspartic acid; binding capacity; cysteine; eukaryotic cells; geometry; glutamic acid; histidine; peptides; transcription factors; zinc; zinc finger motif
- ... CCHH-type zinc fingers are among the most common DNA binding motifs found in eukaryotes. In a previous report, we substituted the second ligand cysteine residue with aspartic acid, producing a Zn(II)-responsive transcription factor; this indicates that a ligand substitution is a possible design target of an engineered zinc finger peptide. Despite the importance of Zn(II) binding with respect to th ...