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- Nazir, Nadiem, et al. Show all 7 Authors
- International journal of biological macromolecules 2019 v.125 pp. 651-659
- glucose; messenger RNA; nutrients; phosphorylation; rapamycin; translation (genetics)
- ... The cap dependent translation initiation is a tightly controlled process of cooperative ternary complex formation by 4E-BP1, eIF4E and the 5′ cap of eukaryotic mRNA in response to environmental cues like glucose, nutrients and growth factor levels. Based on the well-described effects of mTORC1/rapamycin complex on 4E-BP1 phosphorylation/s, it is generally accepted that rapamycin is a global inhibi ...