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1. Delayed type hypersensitivity induced by intradermal inoculation of a Neospora caninum tachyzoite antigen in previously exposed cattle

Author:
Fiorani, Franco; Armendano, Joaquín I.; Hecker, Yanina P.; Araoz, Virginia; Cantón, Germán J.; Leunda, María R.; Pereyra, Susana B.; Corva, Pablo M.; Odeón, Anselmo C.; Moore, Dadín P.
Source:
Veterinary immunology and immunopathology 2019 v.207 pp. 31-35
ISSN:
0165-2427
Subject:
Neospora caninum,   etc   ; Protozoa; antibodies; antigens; cell-mediated immunity; cows; delayed hypersensitivity; interferon-gamma; neosporosis; skinfold thickness; tachyzoites; vaccines;     Show all 12 Subjects
Abstract:
... The aim of this study was to evaluate delayed type hypersensitivity (DTH) induced by the intradermal inoculation of a Neospora caninum tachyzoite soluble lysate in cattle previously exposed with the protozoa. Four experimental groups were selected according to the prior exposure to N. caninum antigen. All cows were intradermally injected with a N. caninum tachyzoite soluble lysate and skinfold thi ...
DOI:
10.1016/j.vetimm.2018.11.011

2. The potential of a DIVA-like recombinant vaccine composed by rNcSAG1 and rAtHsp81.2 against vertical transmission in a mouse model of congenital neosporosis

Author:
Bengoa-Luoni, Sofia A.; Corigliano, Mariana G.; Sánchez-López, Edwin; Albarracín, Romina M.; Legarralde, Ariel; Ganuza, Agustina; Clemente, Marina; Sander, Valeria A.
Source:
Acta tropica 2019 v.198 pp. 105094
ISSN:
0001-706X
Subject:
Neospora caninum,   etc   ; Arabidopsis thaliana; adjuvants; animal models; antibodies; cattle; etiological agents; females; heat shock proteins; immunoglobulin G; infectious diseases; mice; neosporosis; progeny; recombinant vaccines; subunit vaccines; surface antigens;     Show all 17 Subjects
Abstract:
... Neospora caninum is the etiological agent of neosporosis, a worldwide infectious disease recognized as the major cause of abortions and reproductive failures in livestock, responsible for significant economic losses in cattle industries. Currently, there are not cost-effective control options for this pathology, and the development of a vaccine involving new and integrated approaches is highly rec ...
DOI:
10.1016/j.actatropica.2019.105094

3. Neospora caninum DNA in feces of crab-eating fox (Cerdocyon thous – Linnaeus, 1776) from northeastern Brazil

Author:
Almeida, Jonatas Campos de; Kim, Pomy de Cássia Peixoto; Melo, Renata Pimentel Bandeira de; Nogueira, Joel Fonseca; Martins, Felippe Danyel Cardoso; Garcia, João Luis; Freire, Roberta Lemos; Mota, Rinaldo Aparecido
Source:
Acta tropica 2019 v.197 pp. 105068
ISSN:
0001-706X
Subject:
Neospora caninum,   etc   ; Cerdocyon thous; DNA; containers; definitive hosts; dogs; feces; gels; genes; internal transcribed spacers; parasites; phylogeny; polymerase chain reaction; Brazil;     Show all 14 Subjects
Abstract:
... Neospora caninum is an obligate intracellular tissue cyst-forming coccidian parasite and it was first described in dogs. Despite the relevance of wild canids in the transmission chain of N. caninum, there are few studies in Brazil. The aim of the present study was to detect N. caninum DNA in feces of free-range and captive crab-eating fox (Cerdocyon thous) from different states of northeastern Bra ...
DOI:
10.1016/j.actatropica.2019.105068

4. Sperm quality and hormonal levels in C57BL/6 mice infected with Neospora caninum

Author:
Bahrami, Somayeh; Mousavi, Seyyede Sedighe; Alborzi, Ali Reza; Mohammadi, Godratollah; Namavari, Mehdi
Source:
Veterinary parasitology 2019 v.273 pp. 5-10
ISSN:
0304-4017
Subject:
Neospora caninum,   etc   ; epididymis; follicle-stimulating hormone; gonads; luteinizing hormone; males; mice; neosporosis; pathogens; sperm concentration; sperm motility; sperm quality; testosterone; thyrotropin;     Show all 14 Subjects
Abstract:
... Neospora caninum is a major pathogen of cattle and dogs, and neosporosis is widespread in five continents. In this study effect of experimental neosporosis on sperm quality of C57BL/6 mice in different days was investigated. Based on the results sperm concentration was not changed in infected groups but neosporosis induced a significant decrease in epididymis sperm motility at 60 days post infecti ...
DOI:
10.1016/j.vetpar.2019.07.010

5. The soluble fraction of Neospora caninum treated with PI-PLC is dominated by NcSRS29B and NcSRS29C

Author:
Bezerra, Marcos Alexandre; Pereira, Luiz Miguel; Baroni, Luciana; Yatsuda, Ana Patrícia
Source:
Experimental parasitology 2019 pp. 107731
ISSN:
0014-4894
Subject:
Neospora caninum,   etc   ; adhesion; antiserum; cattle; fluorescent antibody technique; glycoproteins; immune evasion; immunogenicity; parasites; phospholipase C; sequence homology; surface antigens; surface proteins;     Show all 13 Subjects
Abstract:
... Neospora caninum is an obligate intracellular parasite related to cases of abortion and fertility impairment in cattle. The control of the parasite still lacks an effective protective strategy and the understanding of key mechanisms for host infection might be crucial for identification of specific targets. There are many proteins related to important mechanisms in the host cell infection cycle su ...
DOI:
10.1016/j.exppara.2019.107731

6. Detection of Neospora caninum DNA in cases of bovine and ovine abortion in the South-West of Scotland

Author:
Bartley, P. M.; Guido, S.; Mason, C.; Stevenson, H.; Chianini, F.; Carty, H.; Innes, E. A.; Katzer, F.
Source:
Parasitology 2019 v.146 no.7 pp. 979-982
ISSN:
1469-8161
Subject:
Neospora caninum,   etc   ; DNA; abortion (animals); brain; cattle; farming systems; fetal death; fetus; financial economics; flocks; heart; internal transcribed spacers; parasites; placenta; polymerase chain reaction; sheep; tissues; Scotland;     Show all 18 Subjects
Abstract:
... Neospora caninum is a commonly diagnosed cause of reproductive losses in farmed ruminants worldwide. This study examined 495 and 308 samples (brain, heart and placenta) which were collected from 455 and 119 aborted cattle and sheep fetuses, respectively. DNA was extracted and a nested Neospora ITS1 PCR was performed on all samples. The results showed that for bovine fetuses 79/449 brain [17.6% (14 ...
DOI:
10.1017/S0031182019000301
PubMed:
30975236 30975236

7. Prevalence of vertically transmitted Neospora caninum amongst beef cattle in Phayao, Thailand

Author:
Japa, Ornampai; Nuangmek, Aniroot; Prakhammin, Khanuengnij; Flynn, Robin J.
Source:
Parasitology international 2019 v.70 pp. 98-101
ISSN:
1383-5769
Subject:
Neospora caninum,   etc   ; DNA; animal tissues; beef cattle; calves; cattle diseases; disease control; laboratory diagnosis; neonates; neosporosis; parasites; placenta; polymerase chain reaction; risk; transplacental transmission; Thailand;     Show all 16 Subjects
Abstract:
... Neospora caninum, the causative agent of neosporosis, is recognised as a significant trigger of abortion and productivity losses in cattle worldwide. Current information regarding to the prevalence of N. caninum in Thailand is limited due to the limitations of detection methods and the difficulty of recovering of viable parasite. Vertical transmission is the main route of N. caninum infection in c ...
DOI:
10.1016/j.parint.2019.02.008

8. Seroprevalence of Neospora caninum infection and associated risk factors in dairy cattle in Serbia

Author:
Klun, Ivana; Ćirković, Vladimir; Maletić, Milan; Bradonjić, Siniša; Djurković-Djaković, Olgica
Source:
Parasitology research 2019 v.118 no.6 pp. 1875-1883
ISSN:
0932-0113
Subject:
Neospora caninum,   etc   ; animal health; antibodies; cattle diseases; confidence interval; cows; dairy cattle; dairy farming; enzyme-linked immunosorbent assay; farms; herd size; neosporosis; regression analysis; risk factors; seroprevalence; Serbia;     Show all 16 Subjects
Abstract:
... Neosporosis in cattle is a globally important disease, causing abortions and significant economic losses if epidemic abortions occur. In Serbia, however, studies of Neospora caninum infection in cattle are few and are based on limited samples and/or from limited areas. We thus performed a nationwide study to examine the seroprevalence of N. caninum infection in a sample of cows randomly selected f ...
DOI:
10.1007/s00436-019-06307-9

9. Genome-wide analyses reveal genes subject to positive selection in Toxoplasma gondii

Author:
Yoshizaki, Sumio; Akahori, Hiromichi; Umemura, Toshiaki; Terada, Tomoyoshi; Takashima, Yasuhiro; Muto, Yoshinori
Source:
Gene 2019 v.699 pp. 73-79
ISSN:
0378-1119
Subject:
Neospora caninum,   etc   ; Hammondia hammondi; Protozoa; Toxoplasma gondii; domestic animals; genes; genome-wide association study; genomics; immune system; immunocompromised population; models; pathogenesis; pathogens; protein products; surface proteins;     Show all 15 Subjects
Abstract:
... Toxoplasma gondii is an important protozoan pathogen that infects many wild and domestic animals and causes infections in immunocompromised humans. However, there has been little investigation of the molecular evolutionary trajectories of this pathogenic protozoa using comparative genomics data. Here, we employed a comparative evolutionary genomics approach to identify genes that are under site- a ...
DOI:
10.1016/j.gene.2019.03.008

10. A probe-based real-time PCR assay for the detection of Neospora caninum in clinical samples from cattle

Author:
Barry, Rhiannon; Nissly, Ruth H.; Feria, Willard; Thirumalapura, Nagaraja; Tewari, Deepanker; Jayarao, Bhushan M.; Kuchipudi, Suresh V.
Source:
Veterinary parasitology 2019 v.269 pp. 2-6
ISSN:
0304-4017
Subject:
Neospora caninum,   etc   ; Chlamydia; DNA; Leptospira; Protozoa; cattle; detection limit; fetus; parasites; pathogens; quantitative polymerase chain reaction; rapid methods; synthetic genes; tissues;     Show all 14 Subjects
Abstract:
... Neospora caninum is an apicomplexan protozoan parasite that is a leading cause of abortion in cattle. Detection of parasite-specific DNA by PCR is a highly sensitive method for identifying the presence of N. caninum in a variety of tissues. We developed and validated a probe-based real-time PCR assay targeting the conserved Nc5 gene of N. caninum. Using N. caninum strain Nc-1 genomic DNA and a syn ...
DOI:
10.1016/j.vetpar.2019.04.002

11. Inflammasome activation restrains the intracellular Neospora caninum proliferation in bovine macrophages

Author:
Wang, Xiaocen; Gong, Pengtao; Zhang, Nan; Li, Lu; Chen, Sining; Jia, Lijun; Liu, Xianyong; Li, Jianhua; Zhang, Xichen
Source:
Veterinary parasitology 2019 v.268 pp. 16-20
ISSN:
0304-4017
Subject:
Neospora caninum,   etc   ; adenosine triphosphate; caspase-1; cattle; cattle diseases; cell death; cell lines; immune response; inflammasomes; macrophages; mice; neosporosis; oligomerization; parasites; pathogens; receptors; tachyzoites; vaccines; vacuoles;     Show all 19 Subjects
Abstract:
... Neospora caninum is an intracellular parasite that causes neosporosis in cattle. Bovine neosporosis is considered a major cause of bovine abortion worldwide. Rapid replication of N. caninum tachyzoites within host cells is responsible for the acute phase of N. caninum infection. Evidence shows that the host immune response plays an essential role in recognizing and regulating the replication of in ...
DOI:
10.1016/j.vetpar.2019.02.008

12. Intestinal parasite infections in dogs affected by multicentric lymphoma and undergoing chemotherapy

Author:
Cervone, Mario; Gavazza, Alessandra; Zbriger, Alina; Mancianti, Francesca; Perrucci, Stefania
Source:
Comparative immunology, microbiology, and infectious diseases 2019 v.63 pp. 81-86
ISSN:
0147-9571
Subject:
Neospora caninum,   etc   ; Cryptosporidium; Entamoeba; Giardia lamblia; Spirocerca lupi; Toxocara canis; dog diseases; dogs; drug therapy; helminthiasis; hookworms; intestines; lymphoma; protozoal infections; species diversity;     Show all 15 Subjects
Abstract:
... Prevalence and species composition of intestinal parasites were evaluated in dogs affected by high-grade multicentric lymphoma and undergoing chemotherapy and in control healthy dogs. Obtained data were statistically analyzed. The overall prevalence of intestinal parasite infections was 33.3%. In lymphoma dogs, the prevalence of protozoa infections (46.7%) was significantly higher (p < 0.05) than ...
DOI:
10.1016/j.cimid.2019.01.006

13. Evidence of reduced vertical transmission of Neospora caninum associated with higher IgG1 than IgG2 serum levels and presence of IFN-γ in non-aborting chronically infected cattle under natural condition

Author:
Pereyra, Rodrigo; Mansilla, Florencia Celeste; Petersen, Marcos Ivan; Suarez, Victor; Capozzo, Alejandra Victoria
Source:
Veterinary immunology and immunopathology 2019 v.208 pp. 53-57
ISSN:
0165-2427
Subject:
Neospora caninum,   etc   ; antibodies; blood serum; calves; cattle diseases; farms; immune response; immunoglobulin G; immunoglobulin M; interferon-gamma; neonates; progeny; seroprevalence; transplacental transmission; vaccine development;     Show all 15 Subjects
Abstract:
... Neospora caninum infection of cattle can be vertically transmitted, resulting in abortion or birth of infected calves. Vertical transmission occurs both in acutely or chronically infected cattle. There is little information on the immune response needed to prevent endogenous transplacental transmission, particularly from chronically infected cattle to their offspring in a natural environment. In t ...
DOI:
10.1016/j.vetimm.2019.01.001

14. First report of Neospora caninum seroprevalence in farmed raccoon dogs in China

Author:
Nie, Lan-Bi; Zou, Yang; Hou, Jun-Ling; Liang, Qin-Li; Cong, Wei; Zhu, Xing-Quan
Source:
Acta tropica 2019 v.190 pp. 80-82
ISSN:
0001-706X
Subject:
Neospora caninum,   etc   ; Nyctereutes procyonoides; Protozoa; adults; animal husbandry; antibodies; blood serum; cities; dog diseases; enzyme-linked immunosorbent assay; females; fetal death; infancy; males; parasites; ruminants; seroprevalence; youth; China;     Show all 19 Subjects
Abstract:
... Neospora caninum is an intracellular protozoan parasite with a worldwide distribution, which can cause abortion and stillbirth in ruminants. However, little is known of N. caninum infection in raccoon dogs in China. Thus, a total of 1181 serum samples of farmed raccoon dogs were collected from the major production areas of Jilin, Changchun in Jilin province, and Rizhao, Weihai and Yantai in Shando ...
DOI:
10.1016/j.actatropica.2018.11.002

15. Seroprevalence of Toxoplasma gondii and Neospora caninum infections and associated factors in sheep from Costa Rica

Author:
Villagra-Blanco, Rodolfo; Barrantes-Granados, Osvaldo; Montero-Caballero, Danilo; Romero-Zúñiga, Juan José; Dolz, Gaby
Source:
Parasite epidemiology and control 2019 v.4 pp. e00085
ISSN:
2405-6731
Subject:
Neospora caninum,   etc   ; Didelphis marsupialis; Tayassu; Toxoplasma gondii; Urocyon cinereoargenteus; antibodies; blood serum; cattle; farms; flocks; foxes; opossums; parasites; questionnaires; reproductive disorders; seroprevalence; sheep; sheep diseases; Costa Rica;     Show all 19 Subjects
Abstract:
... The presence of antibodies against Toxoplasma gondii and Neospora caninum were analyzed in 392 sheep sera from ten Costa Rican ovine flocks using indirect immuno-enzymatic assays. Additionally, general information about sheep management, environment, and clinical reproductive disorders was assessed through a questionnaire to inquire factors related to these apicomplexan parasites. A total of 161 ( ...
DOI:
10.1016/j.parepi.2019.e00085

16. Actin from the apicomplexan Neospora caninum (NcACT) has different isoforms in 2D electrophoresis

Author:
Baroni, Luciana; Pollo-Oliveira, Letícia; Heck, Albert JR; Altelaar, AF Maarten; Yatsuda, Ana Patrícia
Source:
Parasitology 2019 v.146 no.1 pp. 33-41
ISSN:
1469-8161
Subject:
Neospora caninum,   etc   ; Western blotting; actin; antibodies; cytochalasin D; electrophoresis; granules; host cell invasion; livestock; mass spectrometry; neonatal mortality; parasites; post-translational modification; tachyzoites; toxins;     Show all 15 Subjects
Abstract:
... Apicomplexan parasites have unconventional actins that play a central role in important cellular processes such as apicoplast replication, motility of dense granules, endocytic trafficking and force generation for motility and host cell invasion. In this study, we investigated the actin of the apicomplexan Neospora caninum – a parasite associated with infectious abortion and neonatal mortality in ...
DOI:
10.1017/S0031182018000872
PubMed:
29871709

17. Neospora caninum DNA in Coyote Fecal Samples Collected in an Urban Environment

Author:
Klein, Claudia; Barua, Shemanti; Liccioli, Stefano; Massolo, Alessandro
Source:
Journal of wildlife diseases 2019 v.55 no.1 pp. 196-199
ISSN:
0090-3558
Subject:
Neospora caninum,   etc   ; Canis latrans; DNA; Odocoileus hemionus; Odocoileus virginianus; bradyzoites; definitive hosts; feces; genes; intermediate hosts; parks; quantitative polymerase chain reaction; urban areas; Alberta;     Show all 14 Subjects
Abstract:
... Definitive hosts of Neospora caninum are species of canids, such as domestic dogs (Canis lupus familiaris), coyotes (Canis latrans) and foxes (Vulpes vulpes), whereas ruminants, such as cattle (Bos taurus), sheep (Ovis aries), and deer (Cervidae) serve as intermediate hosts. We investigated the presence of N. caninum in feces of coyotes in Calgary, Alberta, Canada. One hundred coyote fecal samples ...
DOI:
10.7589/2018-02-027

18. Serological prevalence of toxoplasmosis and neosporosis in dogs diagnosed with suspected meningoencephalitis in the UK

Author:
Coelho, A. M.; Cherubini, G.; De Stefani, A.; Negrin, A.; Gutierrez‐Quintana, R.; Bersan, E.; Guevar, J.
Source:
Thejournal of small animal practice 2019 v.60 no.1 pp. 44-50
ISSN:
0022-4510
Subject:
Neospora caninum,   etc   ; Toxoplasma gondii; antibodies; dogs; drug therapy; fluorescence; immunoglobulin G; immunoglobulin M; immunosuppression; medical records; meningoencephalitis; neosporosis; pathogens; polymerase chain reaction; protozoal infections; risk; toxoplasmosis; United Kingdom;     Show all 18 Subjects
Abstract:
... OBJECTIVES: To assess the prevalence of antibodies to Toxoplasma gondii and Neospora caninum in a population of dogs with a diagnosis of suspected inflammatory meningoencephalitis. MATERIALS AND METHODS: Medical records of three referral centres were reviewed from 2008 to 2016 to identify a cohort of dogs diagnosed and treated for suspected inflammatory meningoencephalitis after testing for eviden ...
DOI:
10.1111/jsap.12937

19. NcGRA17 is an important regulator of parasitophorous vacuole morphology and pathogenicity of Neospora caninum

Author:
Yang, Congshan; Liu, Jing; Ma, Lei; Zhang, Xichen; Zhang, Xiao; Zhou, Bingxin; Zhu, Xingquan; Liu, Qun
Source:
Veterinary parasitology 2018 v.264 pp. 26-34
ISSN:
0304-4017
Subject:
Neospora caninum,   etc   ; Protozoa; cattle; gene editing; granules; mice; mutants; parasites; phenotype; vacuoles; virulence;     Show all 11 Subjects
Abstract:
... Neospora caninum is an obligate intracellular protozoan parasite that infects a wide range of mammalian species, and particularly causes the reproductive loss in cattle. We identified a novel dense granule protein, N. caninum granule protein 17 (NcGRA17) using the CRISPR/cas9 genome editing system and studied its function. We generated the NcGRA17 knockout strain (ΔNcGRA17) and NcGRA17 complementa ...
DOI:
10.1016/j.vetpar.2018.03.018

20. Toxoplasma CRISPR/Cas9 constructs are functional for gene disruption in Neospora caninum

Author:
Arranz-Solís, David; Regidor-Cerrillo, Javier; Lourido, Sebastian; Ortega-Mora, Luis Miguel; Saeij, Jeroen P.J.
Source:
International journal for parasitology 2018 v.48 no.8 pp. 597-600
ISSN:
0020-7519
Subject:
Neospora caninum,   etc   ; Toxoplasma gondii; cattle; gene editing; gene targeting; genes; green fluorescent protein; parasites; plasmids; pyrimethamine;     Show all 10 Subjects
Abstract:
... Herein we describe, to our knowledge for the first time the use of the clustered regularly interspaced short palindromic repeats/CRISPR-associated gene 9 (CRISPR/Cas9) system for genome editing of Neospora caninum, an apicomplexan parasite considered one of the main causes of abortion in cattle worldwide. By using plasmids containing the CRISPR/Cas9 components adapted to the closely related parasi ...
DOI:
10.1016/j.ijpara.2018.03.002