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- Ng, Hooi Hooi, et al. Show all 3 Authors
- Molecular and cellular endocrinology 2019 v.487 pp. 40-44
- G-protein coupled receptors; agonists; cardiovascular diseases; drugs; half life; intravenous injection; ligands; liver cirrhosis; muscles; peptide receptors; relaxin; therapeutics
- ... The peptide hormone relaxin has beneficial roles in several organs through its action on its cognate G protein-coupled receptor, RXFP1. Relaxin administration is limited to intravenous, subcutaneous, intramuscular, or spinal injection. Another drawback of peptide-based therapy is the short half-life, which requires continuous delivery of the drug to achieve efficient concentration in target organs ...
- Ng, Hooi Hooi, et al. Show all 5 Authors
- Molecular and cellular endocrinology 2019 v.487 pp. 59-65
- agonists; collagen; extracellular matrix; fibrosis; inflammation; peptide receptors; relaxin; signal transduction
- ... Fibrosis is associated with accumulation of excess fibrillar collagen, leading to tissue dysfunction. Numerous processes, including inflammation, myofibroblast activation, and endothelial-to-mesenchymal transition, play a role in the establishment and progression of fibrosis. Relaxin is a peptide hormone with well-known antifibrotic properties that result from its action on numerous cellular targe ...