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- Nishimura, Riko, et al. Show all 8 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.23 pp. 9409-9414
- RNA-binding proteins; autoimmune diseases; autoimmunity; blood serum; encephalitis; interleukin-1beta; interleukin-6; macrophages; messenger RNA; mice; ribonucleases; tumor necrosis factor-alpha
- ... Posttranscriptional regulation of IL-6 has been largely uncharacterized, with the exception of the ribonuclease Regnase-1, which prevents autoimmunity by destabilizing IL-6 mRNA. Here, we identified AT-rich interactive domain-containing protein 5A (Arid5a) as a unique RNA binding protein, which stabilizes IL-6 but not TNF-α mRNA through binding to the 3′ untranslated region of IL-6 mRNA. Arid5a wa ...
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