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- Ogden, Carol Anne, et al. Show all 13 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2011 v.108 no.28 pp. 11578-11583
- Listeria monocytogenes; cations; immune response; innate immunity; interleukin-12; ion channels; listeriosis; metabolites; mice; microbial growth; monocytes; pathogens; phenotype; reactive oxygen species
- ... The generation of reactive oxygen species (ROS) is inherent to immune responses. ROS are crucially involved in host defense against pathogens by promoting bacterial killing, but also as signaling agents coordinating the production of cytokines. Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca²⁺-permeable channel gated via binding of ADP-ribose, a metabolite formed under conditions of cell ...
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