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- Okuda, Chinatsu, et al. Show all 6 Authors
- Biochemical and biophysical research communications 2018 v.503 no.2 pp. 1070-1074
- animal disease models; antihypertensive effect; blood pressure; bovine serum albumin; cholecystokinin; dipeptides; hypertension; oral administration; rats; secretion
- ... We previously reported that an orally administered dipeptide, Arg-Phe (RF), which causes enteroendocrine cell responses, lowered blood pressure in spontaneously hypertensive rats (SHRs). In this study, we found that Phe-Trp (FW), induced the most potent enteroendocrine cell responses out of total 338 dipeptides. An FW analogue, Phe-Trp-Gly-Lys (FWGK), which was effectively produced by tryptic dige ...