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- Oshima, Masanobu, et al. Show all 11 Authors
- Journal of functional foods 2018 v.50 pp. 192-200
- animal models; apoptosis; blood flow; carcinogenesis; chemical constituents of plants; curcumin; curry; epithelium; food intake; functional foods; growth retardation; mice; mortality; neoplasm cells; pyrolysis; stomach neoplasms
- ... Gastric cancer is the second leading cause of cancer-related mortality worldwide. Curcumin, a phytochemical, possesses molecular inhibitory potentials for regulating malignancies. However, the lower potential of curcumin warrants improvement. Thus, we synthesized diarylpentanoid analogs with higher potency; however, these differed structurally from curcumin—a heptanoid. Recently, one diarylpentano ...
- Oshima, Masanobu, et al. Show all 20 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.40 pp. 17163-17168
- brain; fluorescence; hepatocyte growth factor receptor; mice; models; neoplasm cells; neoplasms; stem cells
- ... Controversy remains over whether the cancer stem cell (CSC) theory applies to all tumors. To determine whether cells within a highly aggressive solid tumor are stochastically or hierarchically organized, we combined a reporter system where the nucleostemin (NS) promoter drives GFP expression (termed NS-GFP) with a mouse brain tumor model induced by retroviral Ras expression on a p16Ink⁴a/p19Arf-de ...
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