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- Ozaki, Yoshiaki, et al. Show all 10 Authors
- The British journal of nutrition 2012 v.107 no.11 pp. 1566-1569
- bioavailability; blood; cis-trans isomers; high performance liquid chromatography; humans; metabolites; mice; oral administration; pharmacokinetics; volunteers
- ... Dietary fucoxanthin has been reported to exert several physiological functions, and fucoxanthinol is considered to be the primary active metabolite of fucoxanthin. However, there is no information about the pharmacokinetics of fucoxanthinol in human subjects. In the present study, eighteen human volunteers were orally administered kombu extract containing 31 mg fucoxanthin, and their peripheral bl ...
- Ozaki, Yoshiaki, et al. Show all 8 Authors
- British journal of nutrition 2009 v.102 no.2 pp. 242-248
- metabolites; oral administration; mice; animal models; pharmacokinetics; xanthophylls; Phaeophycophyta; animal tissues; tissue analysis; Japan
- ... The pharmacokinetics of dietary fucoxanthin, one of the xanthophylls in brown sea algae, is little understood. In the present study, mice were orally administered fucoxanthin, and the distribution and accumulation of fucoxanthin and its metabolites fucoxanthinol and amarouciaxanthin A were measured in the plasma, erythrocytes, liver, lung, kidney, heart, spleen and adipose tissue. In a single oral ...