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- Pala, Elif, et al. Show all 9 Authors
- Molecular biology reports 2015 v.42 no.2 pp. 507-516
- bladder; carcinoma; chromosomes; epigenetics; exons; heterozygosity; mutation; oncogenes; patients; promoter regions; transcription factors; tumor suppressor genes; urinary bladder neoplasms
- ... Cancer is a consequence of accumulation of genetic and epigenetic alterations in the cell which can lead to activation of oncogenes or inactivation of tumor suppressor genes (TSG). Since members of ING family were discovered as TSGs in different cancer types, it was aimed to analyze the chromosome 13q33-34 region, ING1 and p53 genes in bladder cancer. 30 paired normal and tumor tissues were invest ...
- Pala, Elif, et al. Show all 12 Authors
- Gene 2014 v.540 pp. 178-182
- DNA repair; H+/K+-exchanging ATPase; H-transporting ATP synthase; Ursidae; adenosinetriphosphatase; calcium; colorectal neoplasms; diagnostic techniques; early diagnosis; females; gene expression; homeostasis; ions; males; mitochondria; mortality; mutation; pathogenesis; patients; proto-oncogenes; quantitative polymerase chain reaction; rectum; reverse transcriptase polymerase chain reaction
- ... Colorectal cancer (CRC) develops as a multi-step process which results from gradual accumulation of mutations in proto-oncogenes, tumor suppressor, and DNA repair genes. Mortality rate of CRC is very high. Therefore, development of alternative diagnostic methods which can be used in the early diagnosis is crucial. ATP2B4 gene encodes one of the four isoforms of p-type ATPase PMCA enzyme and bears ...