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1. Effect of Arginine-Rich Peptide Length on the Structure and Binding Strength of siRNA–Peptide Complexes B

Author:
Park, Jae Chan,   et al.   ; Kim, Minwoo; Kim, Hyun Ryoung; Chae, Su Young; Larson, Ronald G.; Lee, Hwankyu;     Show all 6 Authors
Source:
The Journal of physical chemistry 2013 v.117 no.23 pp. 6917-6926
ISSN:
1520-5207
Subject:
arginine; chemical elements; heparin; molecular dynamics; peptides; small interfering RNA
Abstract:
... Heparin decomplexation experiments, as well as all-atom (AA) and coarse-grained (CG) molecular dynamics (MD) simulations, were performed to determine the effect of the size of arginine(Arg)-rich peptides on the structure and binding strength of the siRNA–peptide complex. At a fixed peptide/siRNA mole ratio of 5:1 or 10:1, the siRNA complexes with peptides longer than nine Arg residues are more eas ...
DOI:
10.1021/jp402868g

2. Effects of the Size, Shape, and Structural Transition of Thermosensitive Polypeptides on the Stability of Lipid Bilayers and Liposomes

Author:
Park, Jae Chan,   et al.   ; Lee, Hwankyu; Kim, Hyun Ryoung; Larson, Ronald G.;     Show all 4 Authors
Source:
Macromolecules 2012 v.45 no.17 pp. 7304-7312
ISSN:
1520-5835
Subject:
cholesterol; drugs; fatty acids; gels; hydrophilicity; hydrophobic bonding; hydrophobicity; lipid bilayers; liquids; molecular dynamics; phase transition; polypeptides; temperature
Abstract:
... We performed all-atom and coarse-grained (CG) molecular dynamics (MD) simulations of lipid bilayers grafted with elastin-like polypeptides (ELPs; [VPGVG]ₙ). All-atom simulations of a single ELP in water show that ELPs become more collapsed and folded as the temperature increases from 293 up to 353 K, in agreement with experiments. All-atom simulations of lipid bilayers composed of dipalmitoylglyce ...
DOI:
10.1021/ma301327j

3. Continuous labeling of circulating tumor cells with microbeads using a vortex micromixer for highly selective isolation

Author:
Park, Jae Chan,   et al.   ; Lin, Ming Xian; Hyun, Kyung-A; Moon, Hui-Sung; Sim, Tae Seok; Lee, Jeong-Gun; Lee, Soo Suk; Jung, Hyo-Il;     Show all 8 Authors
Source:
Biosensors & bioelectronics 2013 v.40 pp. 63-67
ISSN:
0956-5663
Subject:
biosensors; blood flow; cell adhesion; leukocytes; metastasis; neoplasm cells; patients
Abstract:
... Circulating tumor cells (CTCs) are identified in transit within the blood stream of cancer patients and have been proven to be a main cause of metastatic disease. Current approaches for the size-based isolation of CTCs have encountered technical challenges as some of the CTCs have a size similar to that of leukocytes and therefore CTCs are often lost in the process. Here, we propose a novel strate ...
DOI:
10.1016/j.bios.2012.06.016

4. Production of bioethanol from lignocellulose: Status and perspectives in Korea

Author:
Park, Jae Chan,   et al.   ; Kim, Jun-Seok; Park, Soon-Chul; Kim, Jin-Woo; Park, Sung-Min; Lee, Jin-Suk;     Show all 6 Authors
Source:
Bioresource technology 2010 v.101 no.13 pp. 4801-4805
ISSN:
0960-8524
Subject:
biomass; emissions; energy; ethanol; ethanol production; feedstocks; gasoline; lignocellulose; macroalgae; plantations; wastes; Korean Peninsula; South East Asia
Abstract:
... The current status and challenges associated with the production and utilization of cellulosic ethanol in Korea are reviewed in this paper. Cellulosic ethanol has emerged as a promising option for mitigating Korea's CO₂ emissions and enhancing its energy security. Korea's limited biomass resources is the most critical barrier to achieving its implementation targets for cellulosic ethanol. Efforts ...
DOI:
10.1016/j.biortech.2009.12.059
PubMed:
20061145

5. Bioreducible hyaluronic acid conjugates as siRNA carrier for tumor targeting

Author:
Park, Jae Chan,   et al.   ; Yoon, Hong Yeol; Kim, Hyun Ryoung; Saravanakumar, Gurusamy; Heo, Roun; Chae, Su Young; Um, Wooram; Kim, Kwangmeyung; Kwon, Ick Chan; Lee, Jun Young; Lee, Doo Sung; Park, Jae Hyung;     Show all 12 Authors
Source:
Journal of controlled release 2013 v.172 no.3 pp. 653-661
ISSN:
0168-3659
Subject:
biodegradability; blood serum; crosslinking; cytosol; disulfide bonds; fibroblasts; gene silencing; hyaluronic acid; in vivo studies; melanoma; mice; nanocarriers; small interfering RNA; translation (genetics)
Abstract:
... The successful clinical translation of siRNA-based therapeutics requires efficient carrier systems that can specifically deliver siRNA within the cytosol of the target cells. Although numerous polymeric nanocarriers forming ionic complexes with siRNA have been investigated for cancer therapy, their poor stability and lack of tumor targetability have impeded their in vivo applications. To surmount ...
DOI:
10.1016/j.jconrel.2013.09.008

6. Simultaneous integration of multiple genes into the Kluyveromyces marxianus chromosome

Author:
Park, Jae Chan,   et al.   ; Heo, Paul; Yang, Tae-Jun; Chung, Soon-Chun; Cheon, Yuna; Kim, Jun-Seob; Park, Jun-Bum; Koo, Hyun Min; Cho, Kwang Myung; Seo, Jin-Ho; Kweon, Dae-Hyuk;     Show all 11 Authors
Source:
Journal of biotechnology 2013 v.167 pp. 323-325
ISSN:
0168-1656
Subject:
DNA repair; Kluyveromyces marxianus; biotechnology; chromosomes; excision; genes; genetic engineering; genetic markers; knockout mutants; labor; probability; yeasts
Abstract:
... While Kluyveromyces marxianus is a promising yeast strain for biotechnological applications, genetic engineering of this strain is still challenging, especially when multiple genes are to be transformed. Sequential gene integration, which takes advantage of repetitive insertion/excision of the URA3 gene as a marker, has been the best option until now, because the URA3-deletion mutant is the only p ...
DOI:
10.1016/j.jbiotec.2013.06.020

7. Robust PEGylated hyaluronic acid nanoparticles as the carrier of doxorubicin: Mineralization and its effect on tumor targetability in vivo

Author:
Park, Jae Chan,   et al.   ; Han, Hwa Seung; Lee, Jungmin; Kim, Hyun Ryoung; Chae, Su Young; Kim, Minwoo; Saravanakumar, Gurusamy; Yoon, Hong Yeol; You, Dong Gil; Ko, Hyewon; Kim, Kwangmeyung; Kwon, Ick Chan; Park, Jae Hyung;     Show all 13 Authors
Source:
Journal of controlled release 2013 v.168 no.2 pp. 105-114
ISSN:
0168-3659
Subject:
doxorubicin; ethylene glycol; hyaluronic acid; ions; mice; mineralization; minerals; nanoparticles; pH
Abstract:
... The in vivo stability and tumor targetability of self-assembled polymeric nanoparticles are crucial for effective drug delivery. In this study, to develop biostable nanoparticles with high tumor targetability, poly(ethylene glycol)-conjugated hyaluronic acid nanoparticles (PEG-HANPs) were mineralized through controlled deposition of inorganic calcium and phosphate ions on the nanoparticular shell ...
DOI:
10.1016/j.jconrel.2013.02.022

8. Characterization of Saccharomyces cerevisiae promoters for heterologous gene expression in Kluyveromyces marxianus

Author:
Park, Jae Chan,   et al.   ; Lee, Ki-Sung; Kim, Jun-Seob; Heo, Paul; Yang, Tae-Jun; Sung, Young-Je; Cheon, Yuna; Koo, Hyun Min; Yu, Byung Jo; Seo, Jin-Ho; Jin, Yong-Su; Kweon, Dae-Hyuk;     Show all 12 Authors
Source:
Applied microbiology and biotechnology 2013 v.97 no.5 pp. 2029-2041
ISSN:
0175-7598
Subject:
Kluyveromyces marxianus; Saccharomyces cerevisiae; carbon; chromosomes; engineering; fluorescence; fluorescence microscopy; gene expression; genes; green fluorescent protein; hosts; industrial applications; plasmid vectors; plasmids; protein synthesis; reverse transcriptase polymerase chain reaction; temperature; yeasts
Abstract:
... Kluyveromyces marxianus is now considered one of the best choices of option for industrial applications of yeast because the strain is able to grow at high temperature, utilizes various carbon sources, and grows fast. However, the use of K. marxianus as a host for industrial applications is still limited. This limitation is largely due to a lack of knowledge on the characteristics of the promoters ...
DOI:
10.1007/s00253-012-4306-7
PubMed:
22911091

9. Two-stage pretreatment of rice straw using aqueous ammonia and dilute acid

Author:
Park, Jae Chan,   et al.   ; Kim, Jin-Woo; Kim, Kyoung Seob; Lee, Jin-Suk; Park, Sung Min; Cho, Hwa-Young; Kim, Jun Seok;     Show all 7 Authors
Source:
Bioresource technology 2011 v.102 no.19 pp. 8992-8999
ISSN:
0960-8524
Subject:
ammonia; cellulose; crystal structure; enzymatic hydrolysis; enzymes; ethanol production; glucose; hemicellulose; lignin; rice straw; sulfuric acid; xylose
Abstract:
... Liberation of fermentable sugars from recalcitrant lignocellulosic biomass is one of the key challenges in production of cellulosic ethanol. Here we developed a two-stage pretreatment process using aqueous ammonia and dilute sulfuric acid in a percolation mode to improve production of fermentable sugars from rice straw. Aqueous NH₃ was used in the first stage which removed lignin selectively but l ...
DOI:
10.1016/j.biortech.2011.06.068
PubMed:
21784629

10. Expression of aldehyde dehydrogenase 6 reduces inhibitory effect of furan derivatives on cell growth and ethanol production in Saccharomyces cerevisiae

Author:
Park, Jae Chan,   et al.   ; Park, Seong-Eon; Koo, Hyun Min; Park, Young Kyoung; Park, Sung Min; Lee, Oh-Kyu; Park, Yong-Cheol; Seo, Jin-Ho;     Show all 8 Authors
Source:
Bioresource technology 2011 v.102 no.10 pp. 6033-6038
ISSN:
0960-8524
Subject:
NADP (coenzyme); Saccharomyces cerevisiae; aldehyde dehydrogenase; batch fermentation; biomass; cell growth; ethanol; ethanol production; furfural; hydroxymethylfurfural; oxidation; toxic substances; yeasts
Abstract:
... Yeast dehydrogenases and reductases were overexpressed in Saccharomyces cerevisiae D452-2 to detoxify 2-furaldehyde (furfural) and 5-hydroxymethyl furaldehyde (HMF), two potent toxic chemicals present in acid-hydrolyzed cellulosic biomass, and hence improve cell growth and ethanol production. Among those enzymes, aldehyde dehydrogenase 6 (ALD6) played the dual roles of direct oxidation of furan de ...
DOI:
10.1016/j.biortech.2011.02.101
PubMed:
21421300

11. Pretreatment of rice straw with ammonia and ionic liquid for lignocellulose conversion to fermentable sugars

Author:
Park, Jae Chan,   et al.   ; Nguyen, Tam-Anh D.; Kim, Kyoung-Rok; Han, Se Jong; Cho, Hwa Young; Kim, Jin Woo; Park, Sung Min; Sim, Sang Jun;     Show all 8 Authors
Source:
Bioresource technology 2010 v.101 no.19 pp. 7432-7438
ISSN:
0960-8524
Subject:
ammonia; biomass; byproducts; cellulose; enzymes; fermentation; glucose; lignocellulose; recycling; rice straw
Abstract:
... Pretreatment technology is a prerequisite to facilitate the release of sugars from a lignocellulosic biomass prior to fermentation. Recently, some pretreatment methods have been tried with ionic liquids, but they were still expensive and unpractical. In this study, an efficient pretreatment method using ammonia and ionic liquid was developed for the recovery of bio-digestible cellulose from a lign ...
DOI:
10.1016/j.biortech.2010.04.053
PubMed:
20466540

12. Identification of gene targets eliciting improved alcohol tolerance in Saccharomyces cerevisiae through inverse metabolic engineering

Author:
Park, Jae Chan,   et al.   ; Hong, Min-Eui; Lee, Ki-Sung; Yu, Byung Jo; Sung, Young-Je; Park, Sung Min; Koo, Hyun Min; Kweon, Dae-Hyuk; Jin, Yong-Su;     Show all 9 Authors
Source:
Journal of biotechnology 2010 v.149 no.1-2 pp. 52-59
ISSN:
0168-1656
Subject:
Saccharomyces cerevisiae; alcohol tolerance; biochemical pathways; biofuels; biomass; biotechnology; ethanol; fermentation; gene overexpression; genes; genomic libraries; glucose; metabolic engineering; phenotype; plasmids; sequence analysis; specific growth rate; yeasts
Abstract:
... The economic production of biofuels from renewable biomass using Saccharomyces cerevisiae requires tolerance to high concentrations of sugar and alcohol. Here we applied an inverse metabolic engineering approach to identify endogenous gene targets conferring improved alcohol tolerance in S. cerevisiae. After transformation with a S. cerevisiae genomic library, enrichment of the transformants exhib ...
DOI:
10.1016/j.jbiotec.2010.06.006