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- Park, Jong-II, et al. Show all 5 Authors
- Colloids and Surfaces B: Biointerfaces 2017
- Fourier transform infrared spectroscopy; antimycin A; bioavailability; biochemical pathways; cell death; cholesterol; colloids; confocal microscopy; cytotoxicity; desorption; drugs; energy; flow cytometry; hydrophobicity; light scattering; lung neoplasms; mammals; matrix-assisted laser desorption-ionization mass spectrometry; membrane potential; mitochondria; mitochondrial membrane; nuclear magnetic resonance spectroscopy; phenylalanine; therapeutics
- ... •Mitochondria are exclusively employed to produce energy required for the vital metabolic functions of the cell. However, mitochondria also play a key role in mammalian cell death. Dissipation in the mitochondria membrane potential causes cell death. Therefore, in cancer therapy, mitochondria are a novel target. Herein, we developed a nano-formulation of Antimycin A specifically targeted towards m ...