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- Peng, Ya-Tong, et al. Show all 7 Authors
- Journal of materials chemistry B 2019 v.7 no.9 pp. 1379-1383
- alpha-mannosidase; deoxynojirimycin; enzyme inhibitors; glycemic effect; mice; pH
- ... A novel supramolecular multivalent glycosidase inhibitor was constructed based on the amphiphilic deoxynojirimycin derivative FA-DNJ. FA-DNJ self-assembled into spherical assemblies with the diameters between 103 nm and 137 nm under different pH values (pH 2–7) and showed a potent glycosidase effect against α-mannosidase with a Kᵢ value of 0.11 μM, an effect that increased approximately 330-fold c ...