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- Author:
- Peter J. Smith, et al. ; Maria Elena Ortiz-Soto; Christian Roth; William J. Barnes; Jürgen Seibel; Breeanna R. Urbanowicz; Fabian Pfrengle; Show all 7 Authors
- Source:
- ACS sustainable chemistry & engineering 2020 v.8 no.32 pp. 11853-11871
- ISSN:
- 2168-0485
- Subject:
- biocompatibility; biodegradability; catalytic activity; derivatization; green chemistry; oligosaccharides; phosphorylase; phytomass; polymerization; polysaccharides
- Abstract:
- ... Polysaccharides are the most important renewable polymers on Earth and hold an enormous potential for the production of ecofriendly functional materials. In addition to being sustainable, they have superior properties to synthetic polymers, particularly in the biomedical field where biocompatibility and biodegradability are vital. Derivatization of polysaccharides obtained from plant biomass paves ...
- DOI:
- 10.1021/acssuschemeng.0c03622
- https://doi.org/10.1021/acssuschemeng.0c03622
- Author:
- Peter J. Smith, et al. ; Hsin-Tzu Wang; William S. York; Maria J. Peña; Breeanna R. Urbanowicz; Show all 5 Authors
- Source:
- Biotechnology for biofuels 2017 v.10 no.1 pp. 286
- ISSN:
- 1754-6834
- Subject:
- Magnoliopsida; biochemical pathways; biomass; biorefining; biosynthesis; biotransformation; cell walls; cellulose; crops; engineering; feedstocks; fuels; grasses; industry; lignin; lignocellulose; value-added products; xylan
- Abstract:
- ... Xylans are the most abundant noncellulosic polysaccharides in lignified secondary cell walls of woody dicots and in both primary and secondary cell walls of grasses. These polysaccharides, which comprise 20–35% of terrestrial biomass, present major challenges for the efficient microbial bioconversion of lignocellulosic feedstocks to fuels and other value-added products. Xylans play a significant r ...
- DOI:
- 10.1186/s13068-017-0973-z
- PubMed:
- 29213325
- PubMed Central:
- PMC5708106
- https://doi.org/10.1186/s13068-017-0973-z
- Author:
- Peter J. Smith, et al. ; Aloka Kumari; Ponnusamy Baskaran; Jude C. Chukwujekwu; Carmen A. de Kock; Johannes Van Staden; Show all 6 Authors
- Source:
- Industrial crops and products 2016 v.84 pp. 199-204
- ISSN:
- 0926-6690
- Subject:
- Bacillus subtilis; Enterococcus faecalis; Escherichia coli; Klebsiella pneumoniae; Micrococcus luteus; Pseudomonas aeruginosa; Staphylococcus aureus; aeroponics; antibacterial properties; antimalarials; bacteria; biomass production; conservation status; cytotoxicity; greenhouses; leaves; medicinal plants; morphogenesis; pharmaceutical industry; roots; traditional medicine
- Abstract:
- ... An aeroponic system provides an opportunity for improving quantity, quality, consistency and biomass production of roots of medicinal plants. Evaluation of bioactivity is required for establishing biomass from an aeroponic system for commercial production and traditional medicinal use. The present study evaluated antibacterial, antiplasmodial and cytotoxicity properties of three-month-old Tetraden ...
- DOI:
- 10.1016/j.indcrop.2016.01.046
- https://doi.org/10.1016/j.indcrop.2016.01.046
- Author:
- Peter J. Smith, et al. ; Mei-Chen Tseng; Show all 2 Author
- Source:
- Marine & freshwater research 2012 v.63 no.3 pp. 198-209
- ISSN:
- 1323-1650
- Subject:
- Thunnus orientalis; demographic statistics; genes; genetic markers; genetic variation; microsatellite repeats; mitochondrial DNA; population structure; topology; New Zealand; Pacific Ocean
- Abstract:
- ... The Pacific bluefin tuna, Thunnus orientalis, is distributed mainly in the north Pacific Ocean, but a few individuals are also found in the south Pacific Ocean. We tested the ‘one-stock’ hypothesis that genetic differentiation is absent between populations from the north and south Pacific Oceans. Three molecular markers, cytochrome (Cyt) b, control region (CR) and microsatellites, were applied to ...
- DOI:
- 10.1071/MF11126
- https://doi.org/10.1071/MF11126
- Author:
- Peter J. Smith, et al. ; Andrea I. Varela; Peter A. Ritchie; Show all 3 Authors
- Source:
- Fisheries research 2013 v.140 pp. 83-90
- ISSN:
- 0165-7836
- Subject:
- DNA; Hoplostethus atlanticus; adults; basins; fisheries; genetic techniques and protocols; genetic variation; heterozygosity; loci; microsatellite repeats; morphometry; otoliths; parasites; population structure; temporal variation; Atlantic Ocean; Australia; Chile; Namibia; New Zealand
- Abstract:
- ... The widely distributed teleost orange roughy, Hoplostethus atlanticus, has been one of the main species targeted in deep-sea fisheries. While morphometric, parasite and otolith analyses have generally found differentiation among populations within ocean basins, genetic techniques have shown contradictory results at different geographical scales. Here, we used nine microsatellite DNA loci to study ...
- DOI:
- 10.1016/j.fishres.2012.12.011
- https://doi.org/10.1016/j.fishres.2012.12.011
- Author:
- Peter J. Smith, et al. ; Andrea I. Varela; Peter A. Ritchie; Show all 3 Authors
- Source:
- Marine biology 2012 v.159 no.5 pp. 1049-1060
- ISSN:
- 0025-3162
- Subject:
- Hoplostethus atlanticus; biogeography; cytochrome b; cytochrome-c oxidase; genetic variation; models; nucleotide sequences; Australia; Chile; Namibia; New Zealand
- Abstract:
- ... The orange roughy Hoplostethus atlanticus is a well-known commercial species with a global distribution. There is no consensus about levels of connectivity among populations despite a range of techniques having been applied. We used cytochrome c oxidase subunit I (COI) and cytochrome b sequences to study genetic connectivity at a global scale. Pairwise ΦST analyses revealed a lack of significant d ...
- DOI:
- 10.1007/s00227-012-1885-x
- https://doi.org/10.1007/s00227-012-1885-x
- Author:
- Peter J. Smith, et al. ; Clinton G.L. Veale; Adrienne L. Edkins; Jo-Anne de la Mare; Carmen de Kock; Setshaba D. Khanye; Show all 6 Authors
- Source:
- Tetrahedron letters 2015 v.56 no.14 pp. 1860-1864
- ISSN:
- 0040-4039
- Subject:
- Lewis acids; Lewis bases; amides; antimalarials; antineoplastic activity; carboxylic acids; catalysts; chemical reactions; chemical structure; esters
- Abstract:
- ... The synthesis of biologically relevant amides and esters is routinely conducted under complex reaction conditions or requires the use of additional catalysts in order to generate sensitive electrophilic species for attack by a nucleophile. Here we present the synthesis of different indolic esters and amides from indolyl-3-carbonyl nitrile, without the requirement of anhydrous reaction conditions o ...
- DOI:
- 10.1016/j.tetlet.2015.02.090
- https://doi.org/10.1016/j.tetlet.2015.02.090
- Author:
- Peter J. Smith, et al. ; Jude C. Chukwujekwu; Stephen O. Amoo; Carmen A. de Kock; Johannes Van Staden; Show all 5 Authors
- Source:
- South African journal of botany 2014 v.94 pp. 6-8
- ISSN:
- 0254-6299
- Subject:
- Buddleja; acetylcholinesterase; alpha-glucosidase; antimalarials; cytotoxicity; ethyl acetate; hexane; leaves; methylene chloride
- Abstract:
- ... The crude ethanolic extract, hexane, dichloromethane, ethyl acetate and aqueous fractions of Buddleja saligna leaves were investigated for antiplasmodial, alpha-glucosidase and acetylcholinesterase inhibitory and cytotoxicity properties. Although the crude extract displayed some level of activity, the hexane fraction demonstrated the best antiplasmodial (IC50=8.5μg/ml), alpha-glucosidase inhibitor ...
- DOI:
- 10.1016/j.sajb.2014.05.003
- https://doi.org/10.1016/j.sajb.2014.05.003
9. In vitro antiplasmodial activity of indole alkaloids from the stem bark of Geissospermum vellosii
- Author:
- Peter J. Smith, et al. ; Flaubert Mbeunkui; Mary H. Grace; Carmen Lategan; Ilya Raskin; Mary Ann Lila; Show all 6 Authors
- Source:
- Journal of ethnopharmacology 2012 v.139 no.2 pp. 471-477
- ISSN:
- 0378-8741
- Subject:
- Plasmodium falciparum; antimalarials; antimicrobial properties; bark; chemical structure; countercurrent chromatography; indole alkaloids; malaria; mass spectrometry; medicinal plants; nuclear magnetic resonance spectroscopy; parasites; stems; South America
- Abstract:
- ... ETHNOPHARMACOLOGICAL RELEVANCE: The stem bark of Geissospermum vellosii has been traditionally used by the native population of northern South America to treat malaria. Indole alkaloids have been previously isolated from this plant, but the antiplasmodial constituents have not yet been described. As part of our ongoing investigations of new bioactive compounds with activity against malaria parasit ...
- DOI:
- 10.1016/j.jep.2011.11.036
- PubMed:
- 22143154
- https://doi.org/10.1016/j.jep.2011.11.036
10. Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties
- Author:
- Peter J. Smith, et al. ; Muneebah Adams; Tameryn Stringer; Carmen De Kock; Kirkwood M. Land; Nicole Liu; Christina Tam; Luisa W. Cheng; Mathew Njoroge; Kelly Chibale; Gregory S. Smith; Show all 11 Authors
- Source:
- Dalton Trans 2016 v.45 no.47 pp. 19086-19095
- ISSN:
- 1477-9226
- Subject:
- Chinese hamsters; Escherichia coli; Lactobacillus; Plasmodium falciparum; Trichomonas vaginalis; X-ray diffraction; animal ovaries; antimalarials; antiparasitic properties; carbon; cells; chemical structure; cytotoxicity; growth retardation; humans; liver microsomes; microbiome; parasites; pathogens; quinolines; screening; strains
- Abstract:
- ... Bioisosteric ferrocenyl-containing quinolines and ferrocenylamines containing organosilanes and their carbon analogues, were prepared and fully characterised. The molecular structures of two ferrocenyl- containing quinolines, determined using single-crystal X-ray diffraction, revealed that the compounds crystallise in a folded conformation. The compounds were screened for their antiplasmodial acti ...
- Handle:
- 10113/5678136
- DOI:
- 10.1039/C6DT03175G
- https://doi.org/10.1039/C6DT03175G
11. Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics
- Author:
- Peter J. Smith, et al. ; Tameryn Stringer; Carmen De Kock; Hajira Guzgay; John Okombo; Jenny Liu; Sierra Kanetake; Jihwan Kim; Christina Tam; Luisa W. Cheng; Denver T. Hendricks; Kirkwood M. Land; Timothy J. Egan; Gregory S. Smith; Show all 14 Authors
- Source:
- Dalton Transactions 2016 v.45 no.34 pp. 13415-13426
- ISSN:
- 1477-9226
- Subject:
- Plasmodium falciparum; Trichomonas vaginalis; X-ray diffraction; antiparasitic properties; bacteria; cell lines; chemical structure; chloroquine; cytotoxicity; esophagus; in vitro studies; neoplasm cells; neoplasms; parasites; pathogens; polyamines; quinoline; screening
- Abstract:
- ... A series of mono- and multimeric polyamine-containing ferrocenyl complexes containing a quinoline motif were prepared. The complexes were characterised by standard techniques. The molecular structure of the monomeric salicylaldimine derivative was elucidated using single crystal X-ray diffraction and was consistent with the proposed structure. The antiplasmodial activity of the compounds were eval ...
- Handle:
- 10113/63169
- DOI:
- 10.1039/C6DT02685K
- https://doi.org/10.1039/C6DT02685K
- Author:
- Peter J. Smith, et al. ; Flaubert Mbeunkui; Mary H. Grace; Carmen Lategan; Ilya Raskin; Mary Ann Lila; Show all 6 Authors
- Source:
- Journal of chromatography 2011 v.879 no.21 pp. 1886-1892
- ISSN:
- 1570-0232
- Subject:
- Spilanthes; amides; antimalarials; carbon; countercurrent chromatography; drugs; flowers; malaria; multiple drug resistance; nuclear magnetic resonance spectroscopy; parasites; phytopharmaceuticals; solvents; stable isotopes
- Abstract:
- ... The development of new antiplasmodial drugs is of primary importance due to the growing problem of multi-drug resistance of malaria parasites. Spilanthes acmella, a plant traditionally used for the treatment of toothache, was targeted as a lead for its potential antiplasmodial activity. A systematic approach for investigating a suitable centrifugal partition chromatography (CPC) solvent system for ...
- DOI:
- 10.1016/j.jchromb.2011.05.013
- https://doi.org/10.1016/j.jchromb.2011.05.013
- Author:
- Peter J. Smith, et al. ; Moses K. Langat; Neil R. Crouch; Leena Pohjala; Päivi Tammela; Dulcie A. Mulholland; Show all 6 Authors
- Source:
- Phytochemistry letters 2012 v.5 no.3 pp. 414-418
- ISSN:
- 1874-3900
- Subject:
- Croton; Plasmodium falciparum; Semliki Forest virus; anticarcinogenic activity; bark; cytotoxicity; humans; liver neoplasms; neoplasm cells; spectroscopy; stigmasterol; virus replication
- Abstract:
- ... Two new ent-kauren-19-oic acid derivatives, ent-14S*-hydroxykaur-16-en-19-oic acid and ent-14S*,17-dihydroxykaur-15-en-19-oic acid together with eleven known compounds ent-kaur-16-en-19-oic acid, ent-kaur-16-en-19-al, ent-12β-hydroxykaur-16-en-19-oic acid, ent-12β-acetoxykaur-16-en-19-oic acid, 8R,13R-epoxylabd-14-ene, eudesm-4(15)-ene-1β,6α-diol, (−)-7-epivaleran-4-one, germacra-4(15), 5E,10(14)- ...
- DOI:
- 10.1016/j.phytol.2012.03.002
- https://doi.org/10.1016/j.phytol.2012.03.002
- Author:
- Peter J. Smith, et al. ; Rocky Graziose; Thirumurugan Rathinasabapathy; Carmen Lategan; Alexander Poulev; Mary Grace; Mary Ann Lila; Ilya Raskin; Show all 8 Authors
- Source:
- Journal of ethnopharmacology 2011 v.133 no.1 pp. 26-30
- ISSN:
- 0378-8741
- Subject:
- Liriodendron tulipifera; alkaloids; bark; countercurrent chromatography; cytotoxicity; fractionation; high performance liquid chromatography; leaf extracts; leaves; sesquiterpenoid lactones; solvents
- Abstract:
- ... AIM OF THE STUDY: The objective of this study was to isolate and characterize the active constituents of the traditionally used antimalarial plant Liriodendron tulipifera by antiplasmodial-assay guided fractionation. MATERIALS AND METHODS: Bark and leaves were extracted with solvents of increasing polarity. Fractions were generated using flash chromatography, counter current chromatography and pre ...
- DOI:
- 10.1016/j.jep.2010.08.059
- PubMed:
- 20826204
- PubMed Central:
- PMC3010440
- https://doi.org/10.1016/j.jep.2010.08.059
- Author:
- Peter J. Smith, et al. ; Emmanuel Chigutsa; Marianne E. Visser; Elizabeth C. Swart; Paolo Denti; Sudeep Pushpakom; Deirdre Egan; Nicholas H. G. Holford; Gary Maartens; Andrew Owen; Helen McIlleron; Show all 11 Authors
- Source:
- Antimicrobial agents and chemotherapy 2011 v.55 no.9 pp. 4122-4127
- ISSN:
- 0066-4804
- Subject:
- Africans; DNA; bioavailability; gene frequency; genes; genetic polymorphism; glycoproteins; heterozygosity; homozygosity; isoniazid; patients; pharmacokinetics; polypeptides; quantitative polymerase chain reaction; transcription (genetics); transporters; tuberculosis; South Africa
- Abstract:
- ... Among patients with tuberculosis, rifampin plasma concentrations and sputum conversion rates have been reported to be lower in Africans. Rifampin is a substrate of P-glycoprotein (coded for by the ABCB1 gene) and organic anion-transporting polypeptide 1B1 (coded for by SLCO1B1). The objectives were to identify genetic polymorphisms of drug transporters and the transcriptional regulators pregnane X ...
- DOI:
- 10.1128/AAC.01833-10
- PubMed:
- 21709081
- PubMed Central:
- PMC3165308
- https://doi.org/10.1128/AAC.01833-10