Jump to Main Content
- Phan, Thi Nhu Quynh, et al. Show all 3 Authors
- Journal of controlled release 2019 v.304 pp. 146-155
- absorption; bioavailability; dielectric properties; droplets; drugs; epithelial cells; gels; hydrophobicity; in vitro studies; in vivo studies; lipophilicity; membrane permeability; mucus; nanocarriers; nanoemulsions; phospholipids
- ... Membrane permeability of charged BCS class 3 drugs can be tremendously improved by the formation of hydrophobic ion-pairs (HIPs), as the lipophilic character of the drug is strongly improved so that it can move across the phospholipid bilayer of epithelial cells. This effect, however, can in most cases only be observed in in vitro studies, where the destabilizing effect of endogenous counterions o ...
- Phan, Thi Nhu Quynh, et al. Show all 4 Authors
- Colloids and Surfaces B: Biointerfaces 2018 v.161 pp. 228-235
- bromelains; chlorides; colloids; droplet size; drug delivery systems; fluorescein diacetate; mucus; papain; swine; trypsin; zeta potential
- ... This study aimed to improve the mucus permeating properties of self-emulsifying drug delivery systems (SEDDS) by anchoring lipidized bromelain, papain and trypsin using palmitoyl chloride. SEDDS containing enzyme-palmitate conjugates were characterized regarding droplet size and zeta potential. Their mucus permeating properties were evaluated by Transwell diffusion and rotating tube method using f ...