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- Plum, Leona, et al. Show all 10 Authors
- Cell 2012 v.149 no.6 pp. 1314-1326
- G-protein coupled receptors; agonists; antagonists; biochemical pathways; food intake; glucose; homeostasis; insulin; insulin resistance; leptin; mice; neurons; nutritional status; obesity; satiety
- ... Hypothalamic neurons expressing Agouti-related peptide (AgRP) are critical for initiating food intake, but druggable biochemical pathways that control this response remain elusive. Thus, genetic ablation of insulin or leptin signaling in AgRP neurons is predicted to reduce satiety but fails to do so. FoxO1 is a shared mediator of both pathways, and its inhibition is required to induce satiety. Acc ...
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