Jump to Main Content
- Quevedo-Castillo, M., et al. Show all 5 Authors
- Biochemical and biophysical research communications 2019 v.508 no.3 pp. 973-979
- animal tissues; epigenetics; gene expression; models; prostatic neoplasms; site-directed mutagenesis; transcription (genetics); transcription factors; transcriptional activation; tumor suppressor genes
- ... XAF1 is a tumor suppressor gene with low or absent expression in cancer. Since transcriptional reactivation or ectopic-mediated expression of XAF1 inhibits tumor growth, it is of great interest to elucidate the molecular mechanisms leading to XAF1 silencing. YY1 is a transcription factor that acts as a repressor or an activator to modulate several cancer-associated cellular processes. Both YY1 and ...