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- Röhrs, Viola, et al. Show all 8 Authors
- Journal of biotechnology 2015 v.212 pp. 134-143
- cyclophilins; drugs; extracellular matrix; fluorescence microscopy; genes; green fluorescent protein; human cell lines; humans; liver; models; portal vein; quantitative polymerase chain reaction; rats; small interfering RNA; tissue repair; toxicity; toxicology
- ... Reconstituted three-dimensional (3D) liver models obtained by engrafting hepatic cells into an extracellular matrix (ECM) are valuable tools to study tissue regeneration, drug action and toxicology ex vivo. The aim of the present study was to establish a system for the functional investigation of a viral vector in a 3D liver model composed of human HepG2 cells on a rat ECM. An adeno-associated vir ...