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1. Antivirals with common targets against highly pathogenic viruses

Author:
Lu, Lu; Su, Shan; Yang, Haitao; Jiang, Shibo
Source:
Cell 2021 v.184 no.6 pp. 1604-1620
ISSN:
0092-8674
Subject:
RNA-directed RNA polymerase,   etc   ; antiviral agents; climate change; globalization; humans; virus transmission;     Show all 6 Subjects
Abstract:
... Historically, emerging viruses appear constantly and have cost millions of human lives. Currently, climate change and intense globalization have created favorable conditions for viral transmission. Therefore, effective antivirals, especially those targeting the conserved protein in multiple unrelated viruses, such as the compounds targeting RNA-dependent RNA polymerase, are urgently needed to comb ...
DOI:
10.1016/j.cell.2021.02.013

2. A novel mitovirus isolated from the phytopathogenic fungus Botryosphaeria dothidea

Author:
Wang, Hui; Liu, Hong; Lu, Xun; Wang, YunSheng; Zhou, Qian
Source:
Archives of virology 2021 v.166 no.5 pp. 1507-1511
ISSN:
0304-8608
Subject:
RNA-directed RNA polymerase,   etc   ; Alternaria arborescens; Botryosphaeria dothidea; Mitovirus; genome; molecular weight; phylogeny; plant pathogenic fungi; virology;     Show all 9 Subjects
Abstract:
... In this study, we isolated and determined the complete genome sequence of a novel mitovirus, “Botryosphaeria dothidea mitovirus 2” (BdMV2), from the phytopathogenic fungus Botryosphaeria dothidea isolate DT-5. BdMV2 has a genome 2,482 nt in length with an A+U content of 67%. The genome of BdMV2 contains a single large open reading frame (ORF) encoding an RNA-dependent RNA polymerase (RdRp) of 717 ...
DOI:
10.1007/s00705-021-05023-z

3. The complete genome sequence of a new mitovirus from the phytopathogenic fungus Colletotrichum higginsianum

Author:
Wang, Hui; Liu, Hong; Zhou, Qian
Source:
Archives of virology 2021 v.166 no.5 pp. 1481-1484
ISSN:
0304-8608
Subject:
RNA-directed RNA polymerase,   etc   ; Botrytis cinerea; Colletotrichum higginsianum; Mitovirus; genome; phylogeny; plant pathogenic fungi; sequence analysis; virology;     Show all 9 Subjects
Abstract:
... In this study, a novel mitovirus designed "Colletotrichum higginsianum mitovirus 1" (ChMV1) was isolated from the phytopathogenic fungus Colletotrichum higginsianum. The genome of this mitovirus is 2,893 nt in length with an A + U content of 61% and contains a large open reading frame (ORF) encoding an RNA-dependent RNA polymerase (RdRp). A BLASTp analysis revealed that the RdRp domain of ChMV1 ha ...
DOI:
10.1007/s00705-021-04996-1

4. RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19

Author:
Jiang, Yi; Yin, Wanchao; Xu, H. Eric
Source:
Biochemical and biophysical research communications 2021 v.538 pp. 47-53
ISSN:
0006-291X
Subject:
RNA-directed RNA polymerase,   etc   ; COVID-19 infection; RNA; RNA replication; Severe acute respiratory syndrome coronavirus 2; drugs; pandemic; research; therapeutics;     Show all 9 Subjects
Abstract:
... Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly become a global pandemic. Although great efforts have been made to develop effective therapeutic interventions, only the nucleotide analog remdesivir was approved for emergency use against COVID-19. Remdesivir targets the RNA-dependent RNA polymerase (RdRp), an essential enzyme fo ...
DOI:
10.1016/j.bbrc.2020.08.116

5. Complete nucleotide sequence of a novel partitivirus infecting the plant-pathogenic fungus Phomopsis vexans

Author:
Zhang, Chao Jun; Zhou, Xin Yu; Zhong, Jie; Guo, Jun; Yang, Xiao Ping; Zhu, Hong Jian
Source:
Archives of virology 2021 v.166 no.1 pp. 291-294
ISSN:
0304-8608
Subject:
RNA-directed RNA polymerase,   etc   ; Deltapartitivirus; Diaporthe; coat proteins; eggplants; open reading frames; phylogeny; plant pathogenic fungi; virology; viruses;     Show all 10 Subjects
Abstract:
... Here, we report the molecular characterization of a novel partitivirus from Phomopsis vexans strain PvHZ002, a plant-pathogenic fungus infecting eggplant. The virus was designated “Phomopsis vexans partitivirus 1” (PvPV1). PvPV1 contains two dsRNA segments, dsRNA1 and dsRNA2, which are 1,662 bp and 1,628 bp long, respectively. Each segment contains a single open reading frame, putatively encoding ...
DOI:
10.1007/s00705-020-04835-9

6. Anti-HCV, nucleotide inhibitors, repurposing against COVID-19

Author:
Elfiky, Abdo A.
Source:
Life sciences 2020 v.248 pp. 117477
ISSN:
0024-3205
Subject:
RNA-directed RNA polymerase,   etc   ; Coronavirinae; humans; models; sequence analysis; China;     Show all 6 Subjects
Abstract:
... A newly emerged Human Coronavirus (HCoV) is reported two months ago in Wuhan, China (COVID-19). Until today >2700 deaths from the 80,000 confirmed cases reported mainly in China and 40 other countries. Human to human transmission is confirmed for COVID-19 by China a month ago. Based on the World Health Organization (WHO) reports, SARS HCoV is responsible for >8000 cases with confirmed 774 deaths. ...
DOI:
10.1016/j.lfs.2020.117477
PubMed:
32119961
PubMed Central:
PMC7089605

7. An improved scheme for infectious bursal disease virus genotype classification based on both genome-segments A and B

Author:
WANG, Yu-long; FAN, Lin-jin; JIANG, Nan; GAO, Li; LI, Kai; GAO, Yu-long; LIU, Chang-jun; CUI, Hong-yu; PAN, Qing; ZHANG, Yan-ping; WANG, Xiao-mei; QI, Xiao-le
Source:
Journal of integrative agriculture 2021 v.20 no.5 pp. 1372-1381
ISSN:
2095-3119
Subject:
RNA-directed RNA polymerase,   etc   ; Infectious bursal disease virus; RNA; agriculture; classification; coat proteins; genome; genotype; infectious bursal disease; molecular epidemiology; phenotype; virulence;     Show all 12 Subjects
Abstract:
... Infectious bursal disease (IBD) is caused by infectious bursal disease virus (IBDV), which has a genome consisting of two segments of double-stranded linear RNA. IBDVs have been traditionally divided into four phenotypes based on their pathogenicity and antigenicity, including classic, variant, very virulent, and attenuated IBDV. With the emergences of divergent molecular characteristics of novel ...
DOI:
10.1016/S2095-3119(20)63424-4

8. A novel negative-stranded RNA virus of the order Bunyavirales identified in Brassica campestris L. ssp. chinensis

Author:
Tang, Liguang; Song, Liping; Ye, Zhibiao; Lin, Chufa; Wang, Bincai; Lin, Jiazao; Gao, Changbin; Wang, Aihua
Source:
Archives of virology 2021 v.166 no.5 pp. 1525-1528
ISSN:
0304-8608
Subject:
RNA-directed RNA polymerase,   etc   ; Brassica rapa subsp. oleifera; Coguvirus; RNA; genome; new genus; nucleocapsid proteins; nucleotide sequences; phylogeny; vegetables; virology; viruses; China;     Show all 13 Subjects
Abstract:
... Here, we report the full-length genome sequence of a novel cogu-like virus identified in Brassica campestris L. ssp. Chinensis (B. campestris), an economically important vegetable in China. This virus, tentatively named “Brassica campestris chinensis coguvirus 1” (BCCoV1), has a bipartite genome that consists of two RNA molecules (RNA1 and RNA2). The negative-stranded (ns) RNA1 is 6757 nt in lengt ...
DOI:
10.1007/s00705-021-05031-z

9. First description of natural concomitant infection of avian nephritis virus and infectious bronchitis virus reveals exacerbated inflammatory response and renal damage in broiler chicks

Author:
Munuswamy, Palanivelu; Ramakrishnan, Saravanan; Latheef, Shyma K.; Kappala, Deepthi; Mariappan, Asok Kumar; Kaore, Megha; Anbazhagan, Karthikeyan; Puvvala, Bhavani; Singh, Karam Pal; Dhama, Kuldeep
Source:
Microbial pathogenesis 2021 v.154 pp. 104830
ISSN:
0882-4010
Subject:
RNA-directed RNA polymerase,   etc   ; ; Avastrovirus 2; Avian nephritis virus; Infectious bronchitis virus; genes; glycoproteins; histopathology; inflammation; interleukin-12; interleukin-13; interleukin-4; macrophages; mixed infection; necropsy; pathogenesis; viruses;     Show all 17 Subjects
Abstract:
... We describe the first report on spontaneous Avian Nephritis Virus (ANV) and Infectious Bronchitis Virus (IBV) concurrent infection in broiler chicks. On necropsy, the kidneys were found swollen with its parenchyma and ureters stuffed with urate flakes. Histopathologically, the renal tubular damage and inflammatory response were severe in concurrently infected birds compared to the cases infected o ...
DOI:
10.1016/j.micpath.2021.104830

10. Identification of (2R,3R)-2-(3,4-dihydroxyphenyl)chroman-3-yl-3,4,5-trihydroxy benzoate as multiple inhibitors of SARS-CoV-2 targets; a systematic molecular modelling approach

Author:
Selvaraj, Jubie; Sundar P, Shyam; Rajan, Logesh; Selvaraj, Divakar; Palanisamy, Dhanabal; Namboori PK, Krishnan; Mohankumar, Suresh Kumar
Source:
RSC advances 2021 v.11 no.22 pp. 13051-13060
ISSN:
2046-2069
Subject:
RNA-directed RNA polymerase,   etc   ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; computer simulation; drugs; epigallocatechin; interleukin-6; molecular dynamics; pandemic; proteinases; serine; zoonoses;     Show all 12 Subjects
Abstract:
... Coronavirus disease of 2019 (COVID-19) is a zoonotic disease caused by a new severe acute respiratory syndrome (SARS-CoV-2) which has quickly resulted in a pandemic. Recent anti-COVID-19 drug discoveries are leaning towards repurposing phytochemicals which have been previously reported for SARS and MERS-CoV outbreaks. However, they have been either virtually screened or tested so far against mono ...
DOI:
10.1039/d1ra01603b

11. Structural analogues of existing anti-viral drugs inhibit SARS-CoV-2 RNA dependent RNA polymerase: A computational hierarchical investigation

Author:
Hasan, Md. Kamrul; Kamruzzaman, Mohammad; Bin Manjur, Omar Hamza; Mahmud, Araf; Hussain, Nazmul; Alam Mondal, Muhammad Shafiul; Hosen, Md. Ismail; Bello, Martiniano; Rahman, Atiqur
Source:
Heliyon 2021 v.7 no.3 pp. e06435
ISSN:
2405-8440
Subject:
RNA-directed RNA polymerase,   etc   ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; drugs; molecular dynamics; mortality; pandemic; therapeutics; virus replication;     Show all 9 Subjects
Abstract:
... The Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a pandemic, resulting in an exponentially increased mortality globally and scientists all over the world are struggling to find suitable solutions to combat it. Multiple repurposed drugs have already been in several clinical trials or recently completed. However, none of them shows ...
DOI:
10.1016/j.heliyon.2021.e06435

12. Ammonium produced from Shewanella strain 0409 contributes to antiviral activity against Betanodavirus

Author:
Wu, Yu-Chi; Tsai, Chia-Hong; Chi, Shau-Chi
Source:
Aquaculture 2021 v.533 pp. 736131
ISSN:
0044-8486
Subject:
RNA-directed RNA polymerase,   etc   ; Betanodavirus; RNA; Shewanella; acidification; adsorption; ammonium; antiviral properties; biological control; disease control; endosomes; evaporation; grouper; heat; intestines; microbiome; pH; virion;     Show all 18 Subjects
Abstract:
... Nervous necrosis virus (NNV) (genus: Betanodavirus) attacks aquacultured fish. Biocontrol may prevent and control the disease caused by NNV infection. Shewanella strain 0409 was isolated from the microbiome of grouper intestines, and its culture supernatant (CS0409) could inhibit NNV replication in vitro. The present study elucidated the antiviral mechanism of Shewanella strain 0409 against NNV in ...
DOI:
10.1016/j.aquaculture.2020.736131

13. Different mutations in SARS-CoV-2 associate with severe and mild outcome

Author:
Nagy, Ádám; Pongor, Sándor; Győrffy, Balázs
Source:
International journal of antimicrobial agents 2021 v.57 no.2 pp. 106272
ISSN:
0924-8579
Subject:
RNA-directed RNA polymerase,   etc   ; amino acids; anti-infective agents; chi-square distribution; correlation; death; disease severity; genes; genomics; glycoproteins; lead; mutation; nucleocapsid; patients; phosphoproteins; prevalence; sampling; testing; viruses;     Show all 19 Subjects
Abstract:
... Genomic alterations in a viral genome can lead to either better or worse outcome and identifying these mutations is of utmost importance. Here, we correlated protein-level mutations in the SARS-CoV-2 virus to clinical outcome.Mutations in viral sequences from the GISAID virus repository were evaluated by using “hCoV-19/Wuhan/WIV04/2019” as the reference. Patient outcomes were classified as mild di ...
DOI:
10.1016/j.ijantimicag.2020.106272

14. The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2

Author:
Jin, Zhenming; Wang, Haofeng; Duan, Yinkai; Yang, Haitao
Source:
Biochemical and biophysical research communications 2021 v.538 pp. 63-71
ISSN:
0006-291X
Subject:
RNA-directed RNA polymerase,   etc   ; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; drug development; drugs; pandemic; polyproteins; proteinases; proteolysis; research; viral genome;     Show all 11 Subjects
Abstract:
... The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (Mᵖʳᵒ) and the RNA-dependent RNA polymerase (RdRP), which are responsible for the viral polyprotein proteolytic proces ...
DOI:
10.1016/j.bbrc.2020.10.091

15. Genomic surveillance of Nevada patients revealed prevalence of unique SARS-CoV-2 variants bearing mutations in the RdRp gene

Author:
Hartley, Paul D.; Tillett, Richard L.; AuCoin, David P.; Sevinsky, Joel R.; Xu, Yanji; Gorzalski, Andrew; Pandori, Mark; Buttery, Erin; Hansen, Holly; Picker, Michael A.; Rossetto, Cyprian C.; Verma, Subhash C.
Source:
Journal of genetics and genomics 2021
ISSN:
1673-8527
Subject:
RNA-directed RNA polymerase,   etc   ; COVID-19 infection; RNA; Severe acute respiratory syndrome coronavirus 2; genes; genomics; monitoring; mutation; nose; phenylalanine; phylogeny; proline; public health; Nevada;     Show all 14 Subjects
Abstract:
... Patients with signs of COVID-19 were tested through diagnostic RT-PCR for SARS-CoV-2 using RNA extracted from the nasopharyngeal/nasal swabs. To determine the variants of SARS-CoV-2 circulating in the state of Nevada, specimens from 200 COVID-19 patients were sequenced through our robust sequencing platform, which enabled sequencing of SARS-CoV-2 from specimens with even very low viral loads, with ...
DOI:
10.1016/j.jgg.2021.01.004

16. Complete genome sequence of a novel mycovirus from Phoma matteucciicola

Author:
Zhou, Jia; Hu, Xiaochuan; Liang, Xiaofei; Wang, Yuhua; Xie, Changping; Zheng, Li
Source:
Archives of virology 2021 v.166 no.1 pp. 317-320
ISSN:
0304-8608
Subject:
RNA-directed RNA polymerase,   etc   ; Curcuma wenyujin; Periconia; Phoma; RNA viruses; asparagine; aspartic acid; genome; length; mycoviruses; open reading frames; phylogeny; virology;     Show all 13 Subjects
Abstract:
... The complete genome sequence of a novel mycovirus, Phoma matteucciicola RNA virus 1 (PmRV1), derived from Phoma matteucciicola strain LG-01, was sequenced and analyzed. The complete cDNA sequence of PmRV1 is 3432 bp in length with a GC content of 57.17%. The genome of PmRV1 contains two putative open reading frames (ORFs): ORF1 and ORF2. ORF1 encodes a hypothetical protein with significant similar ...
DOI:
10.1007/s00705-020-04865-3

17. Potential compounds from several Indonesian plants to prevent SARS-CoV-2 infection: A mini-review of SARS-CoV-2 therapeutic targets

Author:
Illian, Didi Nurhadi; Siregar, Etti Sartina; Sumaiyah, Sumaiyah; Utomo, Ahmad Rusdan; Nuryawan, Arif; Basyuni, Mohammad
Source:
Heliyon 2021 v.7 no.1 pp. e06001
ISSN:
2405-8440
Subject:
RNA-directed RNA polymerase,   etc   ; Severe acute respiratory syndrome coronavirus 2; humans; peptidyl-dipeptidase A; research and development; serine proteinases; therapeutics; Indonesia;     Show all 8 Subjects
Abstract:
... The outbreak of coronaviruses (CoVs) presents an enormous threat to humans. To date, no new therapeutic drugs or vaccines licensed to treat human coronaviruses remain undiscovered. This mini-review briefly reports the number of potential plants widely distributed in Indonesia for further research and development as anti-SARS-CoV-2 agents and the critical targets for SARS-CoV-2 therapy, such as ang ...
DOI:
10.1016/j.heliyon.2021.e06001

18. Heterogeneous Nuclear Ribonucleoproteins Participate in Hepatitis E Virus Replication

Author:
Pingale, Kunal D.; Kanade, Gayatri D.; Karpe, Yogesh A.
Source:
Journal of molecular biology 2020 v.432 no.7 pp. 2369-2387
ISSN:
0022-2836
Subject:
RNA-directed RNA polymerase,   etc   ; Orthohepevirus A; RNA; cytoplasm; genomics; promoter regions; ribonucleoproteins; virus replication;     Show all 8 Subjects
Abstract:
... Coordinated assembly of viral and host factors is essential for the successful propagation of viruses as well as the generation of host antiviral response. Previous studies from our group, as well as from other groups, have identified host proteins interacting with various components of the hepatitis E virus (HEV). However, the functional relevance of host protein interactions in HEV replication c ...
DOI:
10.1016/j.jmb.2020.02.025

19. Ebola virus replication is regulated by the phosphorylation of viral protein VP35

Author:
Zhu, Lin; Gao, Ting; Yang, Weihong; Liu, Yaoning; Liu, Xuan; Hu, Yong; Jin, Yanwen; Li, Ping; Xu, Ke; Zou, Gang; Zhao, Lei; Cao, Ruiyuan; Zhong, Wu; Xia, Xianzhu; Cao, Cheng
Source:
Biochemical and biophysical research communications 2020 v.521 no.3 pp. 687-692
ISSN:
0006-291X
Subject:
RNA-directed RNA polymerase,   etc   ; Ebolavirus; genomics; humans; immunoblotting; mutants; pathogens; phosphorylation; research; serine; threonine; virus replication;     Show all 12 Subjects
Abstract:
... Ebola virus (EBOV) is a zoonotic pathogen, the infection often results in severe, potentially fatal, systematic disease in human and nonhuman primates. VP35, an essential viral RNA-dependent RNA polymerase cofactor, is indispensable for Ebola viral replication and host innate immune escape. In this study, VP35 was demonstrated to be phosphorylated at Serine/Threonine by immunoblotting, and the maj ...
DOI:
10.1016/j.bbrc.2019.10.147

20. Micronutrients and bioactive substances: Their potential roles in combating COVID-19

Author:
Keflie, Tibebeselassie Seyoum; Biesalski, Hans Konrad
Source:
Nutrition 2021 v.84 pp. 111103
ISSN:
0899-9007
Subject:
RNA-directed RNA polymerase,   etc   ; COVID-19 infection; Echinacea; Severe acute respiratory syndrome coronavirus 2; antioxidants; curcumin; garlic; glycoproteins; green tea; nutrition; pandemic; polyphenols; propolis; proteinases; public health; selenium; serine; soybeans; zinc;     Show all 19 Subjects
Abstract:
... The coronavirus disease 2019 (COVID-19) pandemic is seriously threatening public health and setting off huge economic crises across the world. In the absence of specific drugs for COVID-19, there is an urgent need to look for alternative approaches. Therefore, the aim of this paper was to review the roles of micronutrients and bioactive substances as potential alternative approaches in combating C ...
DOI:
10.1016/j.nut.2020.111103