Jump to Main Content
- Rajasekharan, Satish Kumar, et al. Show all 3 Authors
- International journal of antimicrobial agents 2019 v.54 no.4 pp. 518-523
- Candida albicans; antipsychotics; biochemical pathways; biofilm; biosynthesis; cyclic AMP; dose response; drug therapy; filipin; flocculation; hyphae; ketoconazole; mechanism of action; multiple drug resistance; propidium; quantitative polymerase chain reaction; reactive oxygen species; reverse transcriptase polymerase chain reaction; staining; sterols; yeasts
- ... Drug repurposing is an anticipative chemotherapeutic strategy that accentuates the inadequacy of antifungal drugs. The study identifies an antipsychotic drug, aripiprazole, as a biofilm and hyphal inhibitor of Candida albicans. Microtitre plate biofilm inhibition, metabolic activity and hyphal inhibitory assays were used to assess the potency of aripiprazole; and filipin staining, reactive oxygen ...
- Rajasekharan, Satish Kumar, et al. Show all 7 Authors
- Microbial pathogenesis 2019 v.130 pp. 104-111
- Pseudomonas aeruginosa; active sites; antimicrobial properties; biofilm; computer simulation; dose response; genes; mechanism of action; messenger RNA; moieties; multiple drug resistance; pathogenesis; pathogens; pyocyanin; quorum sensing; urea
- ... Emergence of multi-drug resistant bacterial pathogens is escalating and it is essential to develop novel strategies to combat these super bugs. LasR is a regulator switch that plays a vital role in quorum sensing (QS) and pathogenesis of Pseudomonas aeruginosa. The present study reports two novel Mannich base (1-(phenyl (o-tolylamino) methyl) urea and 3-((1H-Imidazole-1-yl) methylnaphthalene-2-ol ...