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- Rajbhandari, Abha K., et al. Show all 8 Authors
- Cell 2019 v.177 no.5 pp. 1280-1292.e20
- action potentials; astrocytes; behavior disorders; gamma-aminobutyric acid; gamma-aminobutyric acid receptors; neurons; phenotype; synapse; synaptic transmission; therapeutics
- ... Hyperactivity and disturbances of attention are common behavioral disorders whose underlying cellular and neural circuit causes are not understood. We report the discovery that striatal astrocytes drive such phenotypes through a hitherto unknown synaptic mechanism. We found that striatal medium spiny neurons (MSNs) triggered astrocyte signaling via γ-aminobutyric acid B (GABAB) receptors. Selectiv ...