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- Richardson, D.L., et al. Show all 5 Authors
- Proceedings of the National Academy of Sciences of the United States of America 1994 v.91 no.22 pp. 10561-10565
- spores; sporulation; structural genes; cyclic AMP; Dictyostelium discoideum; gene expression; cell differentiation
- ... The activity of cAMP-dependent protein kinase (PKA) is required for proper development at several stages during the Dictyostelium life cycle. We present evidence that activation of PKA is rate-limiting for the differentiation of prespore cells to spores and that PKA activation may be the developmental trigger for sporulation. Strains that overexpress the gene encoding the catalytic subunit of PKA ...
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