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You searched for: Author "Robert E. Briggs" Remove constraint Author: "Robert E. Briggs"
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1. Comparative study of antibacterial activity and stability of D-enantiomeric and L-enantiomeric bovine NK-lysin peptide NK2A

Author:
Robert E. Briggs,   et al.   ; Rohana P. Dassanayake; Tracy J. Porter; Daniel Samorodnitsky; Shollie M. Falkenberg; Eric M. Nicholson; Fred M. Tatum; Mitchell V. Palmer; Eduardo Casas;     Show all 9 Authors
Source:
Biochemical and biophysical research communications 2022 v.595 pp. 76-81
ISSN:
0006-291X
Subject:
Haemophilus somni; animal models; antibacterial properties; antimicrobial peptides; blood serum; cattle; circular dichroism spectroscopy; comparative study; digestion; mass spectrometry; mechanism of action; proteolysis; research; septicemia; toxicity; transmission electron microscopy; trypsin
Abstract:
... L-enantiomers of antimicrobial peptides (AMPs) are sensitive to proteolytic degradation; however, D-enantiomers of AMPs are expected to provide improved proteolytic resistance. The present study aimed to comparatively investigate the in vitro antibacterial activity, trypsin and serum stability, toxicity, and in vivo antibacterial activity of L-enantiomeric bovine NK2A (L-NK2A) and its D-enantiomer ...
Handle:
10113/7638105
DOI:
10.1016/j.bbrc.2022.01.071

2. Protection against Mycoplasma bovis infection in calves following intranasal vaccination with modified-live Mannheimia haemolytica expressing Mycoplasma antigens

Author:
Robert E. Briggs,   et al.   ; Sheila R. Billing; William D. Boatwright; Bradley O. Chriswell; Eduardo Casas; Rohana P. Dassanayake; Mitchell V. Palmer; Karen B. Register; Fred M. Tatum;     Show all 9 Authors
Source:
Microbial pathogenesis 2021 v.161 pp. 105159
ISSN:
0882-4010
Subject:
Mannheimia haemolytica; Mycoplasma bovis; antibodies; antigens; heat shock proteins; leukotoxins; live vaccines; lungs; middle ear; pathogenesis; peptide elongation factors; serotypes; vaccination; virulence
Abstract:
... Novel live vaccine strains of Mannheimia haemolytica serotypes (St)1 and St6, expressing and secreting inactive yet immunogenic leukotoxin (leukotoxoid) fused to antigenic domains of Mycoplasma bovis Elongation Factor Tu (EFTu) and Heat shock protein (Hsp) 70 were constructed and tested for efficacy in cattle. Control calves were administered an intranasal mixture of M. haemolytica St1 and St6 mut ...
DOI:
10.1016/j.micpath.2021.105159

3. A multiplex PCR assay for molecular capsular serotyping of Mannheimia haemolytica serotypes 1, 2, and 6

Author:
Robert E. Briggs,   et al.   ; Cassidy L. Klima; Rahat Zaheer; Tim A. McAllister;     Show all 4 Authors
Source:
Journal of microbiological methods 2017 v.139 pp. 155-160
ISSN:
0167-7012
Subject:
Mannheimia haemolytica; agglutination; antiserum; cattle; cost effectiveness; genes; pathogens; polymerase chain reaction; polysaccharides; serotypes
Abstract:
... Mannheimia haemolytica is an important respiratory pathogen of ruminants. Of the 12 capsular serovars identified, 1 and 6 are most frequently associated with disease in cattle, while 2 is largely a commensal. Comparative analysis of 24 M. haemolytica genomes was used to identify unique genes associated with capsular polysaccharide synthesis as amplification targets in a multiplex PCR assay to disc ...
Handle:
10113/5706134
DOI:
10.1016/j.mimet.2017.05.010

4. Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni

Author:
Robert E. Briggs,   et al.   ; Rohana P. Dassanayake; Shollie M. Falkenberg; Fred M. Tatum; Randy E. Sacco;     Show all 5 Authors
Source:
Plos One 2017 v.12 no.8 pp. 1-14
ISSN:
1932-6203
Subject:
Haemophilus somni; animal pathogenic bacteria; antibacterial properties; bovine respiratory disease; cattle; cell membranes; cytotoxic T-lymphocytes; electron microscopy; flow cytometry; granules; peptides
Abstract:
... Bovine NK-lysins, which are functionally and structurally similar to human granulysin and porcine NK-lysin, are predominantly found in the granules of cytotoxic T-lymphocytes and NK-cells. Although antimicrobial activity of bovine NK-lysin has been assessed for several bacterial pathogens, not all the important bacterial pathogens that are involved in the bovine respiratory disease complex have be ...
Handle:
10113/5801864
DOI:
10.1371/journal.pone.0183610
PubMed:
28827826
PubMed Central:
PMC5565109

5. Genome Sequences of Serotype A6 Mannheimia haemolytica Isolates D174 and D38 Recovered from Bovine Pneumonia

Author:
Robert E. Briggs,   et al.   ; Melissa J. Hauglund; Fred M. Tatum; Darrell O. Bayles; Samuel K. Maheswaran;     Show all 5 Authors
Source:
Genome Announcements 2015 v.3 no.2 pp. e00086-15
ISSN:
2169-8287
Subject:
Mannheimia haemolytica; anti-infective agents; cattle; drugs; genome; nucleotide sequences; pneumonia; serotypes; virulence
Abstract:
... Here, we report two genomes, one complete and one draft, from virulent bovine strains of Mannheimia haemolytica serotype A6 recovered prior to the field usage of modern antimicrobial drugs. ...
Handle:
10113/61593
DOI:
10.1128/genomeA.00086-15
PubMed:
25745008
PubMed Central:
PMC4358395

6. Bivalent vaccination against pneumonic pasteurellosis in domestic sheep and goats with modified-live in-frame lktA deletion mutants of Mannheimia haemolytica

Author:
Robert E. Briggs,   et al.   ; Melissa J. Hauglund; Samuel K. Maheswaran; Fred M. Tatum;     Show all 4 Authors
Source:
Microbial pathogenesis 2013 v.64 no. pp. 43-47
ISSN:
0882-4010
Subject:
Mannheimia haemolytica; genetic vectors; goats; lesions (animal); liver; lungs; molecular weight; monoclonal antibodies; mutants; pneumonic pasteurellosis; serotypes; sheep; structural genes; vaccination; vaccines; virulence
Abstract:
... A temperature-sensitive shuttle vector, pBB80C, was utilized to generate in-frame deletion mutants of the leukotoxin structural gene (lktA) of Mannheimia haemolytica serotypes 1, 2, 5, 6, 7, 8, 9, and 12. Culture supernatants from the mutants contained a truncated protein with an approximate molecular weight of 66 kDa which was reactive to anti-leukotoxin monoclonal antibody. No protein reactive t ...
Handle:
10113/61196
DOI:
10.1016/j.micpath.2013.08.004

7. Genome Sequences of Mannheimia haemolytica Serotype A2 Isolates D171 and D35, Recovered from Bovine Pneumonia

Author:
Robert E. Briggs,   et al.   ; Melissa J. Hauglund; Fred M. Tatum; Darrell O. Bayles; Samuel K. Maheswaran;     Show all 5 Authors
Source:
Genome Announcements 2015 v.3 no.2 pp. e00093-15
ISSN:
2169-8287
Subject:
Mannheimia haemolytica; bacterial pneumonia; cattle; cattle diseases; genome; nucleotide sequences; serotypes
Abstract:
... Here, we report two genomes, one complete and one draft, from isolates of serotype A2 Mannheimia haemolytica recovered from pneumonic bovine lung. ...
Handle:
10113/61193
DOI:
10.1128/genomeA.00093-15
PubMed:
25767233
PubMed Central:
PMC4357755

8. Mucosal and parenteral vaccination against pneumonic pasteurellosis with a modified-live in-frame lktA deletion mutant of Mannheimia haemolytica.

Author:
Robert E. Briggs,   et al.   ; Louisa B. Tabatabia; Fred M. Tatum;     Show all 3 Authors
Source:
Microbial Pathogenesis 2012 v.52 pp. 302-309
ISSN:
0882-4010
Subject:
Mannheimia haemolytica serotype 1; antibody formation; calves; cytotoxicity; genetic vectors; lesions (animal); leukotoxins; lungs; lymphocytes; molecular weight; mutants; oral vaccination; pneumonic pasteurellosis; structural genes; subcutaneous injection
Abstract:
... A new temperature-conditional shuttle vector, pBB80C, was constructed and utilized to generate an inframe deletion in the leukotoxin structural gene of Mannheimia haemolytica serotype 1. Culture supernatants from the mutant contained no detectable cytotoxicity to BL-3 lymphocyte targets, and contained a new protein with an approximate molecular weight of 66 kDa which was reactive to anti-leukotoxi ...
Handle:
10113/57610
DOI:
10.1016/j.micpath.2012.02.008

9. Genome Sequences of Mannheimia haemolytica Serotype A1 Strains D153 and D193 from Bovine Pneumonia

Author:
Robert E. Briggs,   et al.   ; Melissa J. Hauglund; Fred M. Tatum; Darrell O. Bayles; Samuel K. Maheswaran;     Show all 5 Authors
Source:
Genome announcements 2013 v.1 no.5 pp. e00848-13
ISSN:
2169-8287
Subject:
Mannheimia haemolytica; bacterial pneumonia; cattle; genome; nucleotide sequences; serotypes; virulence
Abstract:
... Here we report two genome sequences, one complete and one draft, from virulent bovine strains of Mannheimia haemolytica serotype A1 recovered prior to the field usage of modern antimicrobial drugs. ...
Handle:
10113/61222
DOI:
10.1128/genomeA.00848-13
PubMed:
24136851
PubMed Central:
PMC3798457

10. Comparative genome analysis of an avirulent and two virulent strains of avian Pasteurella multocida reveals candidate genes involved in fitness and pathogenicity

Author:
Robert E. Briggs,   et al.   ; Timothy J. Johnson; Juan E. Abrahante; Samuel S. Hunter; Melissa Hauglund; Fred M. Tatum; Samuel K. Maheswaran;     Show all 7 Authors
Source:
BMC microbiology 2013 v.13 no.106 pp. 1-10
ISSN:
1471-2180
Subject:
chickens; sugars; avirulent strains; fowl cholera; transporters; turkeys; outer membrane proteins; hemagglutinins; genes; nucleotide sequences; virulence; Pasteurella multocida; single nucleotide polymorphism
Abstract:
... Background: Pasteurella multocida is the etiologic agent of fowl cholera, a highly contagious and severe disease of poultry causing significant mortality and morbidity throughout the world. All types of poultry are susceptible to fowl cholera. Turkeys are most susceptible to the peracute/acute forms of the disease while chickens are most susceptible to the acute and chronic forms of the disease. T ...
Handle:
10113/57504
DOI:
10.1186/1471-2180-13-106
PubMed:
23672515
PubMed Central:
PMC3660278

11. Draft Genome Sequences of Two Virulent Serotypes of Avian Pasteurella multocida

Author:
Robert E. Briggs,   et al.   ; Juan E. Abrahante; Timothy J. Johnson; Samuel S. Hunter; Samuel K. Maheswaran; Melissa J. Hauglund; Darrell O. Bayles; Fred M. Tatum;     Show all 8 Authors
Source:
Genome announcements 2013 v.1 no.1 pp. e00058-12
ISSN:
2169-8287
Subject:
Pasteurella multocida; birds; genome; nucleotide sequences; serotypes; virulence
Abstract:
... Here we report the draft genome sequences of two virulent avian strains of Pasteurella multocida. Comparative analyses of these genomes were done with the published genome sequence of avirulent P. multocida strain Pm70. ...
Handle:
10113/61195
DOI:
10.1128/genomeA.00058-12
PubMed:
23405337
PubMed Central:
PMC3569333