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- Rodrigo, Ledesma-Amaro, et al. Show all 8 Authors
- Metabolic engineering 2019 v.51 pp. 59-69
- Bacillus subtilis; N-acetylglucosamine; NAD (coenzyme); acetyl coenzyme A; byproducts; carbon; carbon metabolism; culture flasks; energy; gene overexpression; genes; glucose; metabolic engineering
- ... One of the primary goals of microbial metabolic engineering is to achieve high titer, yield and productivity (TYP) of engineered strains. This TYP index requires optimized carbon flux toward desired molecule with minimal by-product formation. De novo redesign of central carbon and redox metabolism holds great promise to alleviate pathway bottleneck and improve carbon and energy utilization efficie ...