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- Rubio, Ignacio, et al. Show all 7 Authors
- Journal of Immunological Methods 2015 v.427 pp. 66-72
- T-lymphocytes; adaptive immunity; adults; density gradient centrifugation; grinding; humans; immune response; phenotype; risk; tonsils; viability
- ... Increasing clinical evidence indicates that removal of the palatine tonsils enhances the risk for adults to suffer from severe illnesses. Together with recent experimental findings pointing to the presence of immunologically competent immune cells these findings illustrate that adult palatine tonsils likely play an appreciable role in the host immune response. T-cells are abundant in the palatine ...
- Rubio, Ignacio, et al. Show all 16 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.51 pp. 20587-20592
- humans; microfilament proteins; mitogen-activated protein kinase; rats; receptor protein-tyrosine kinase; recombinant proteins; sarcoma; signal transduction
- ... Receptor tyrosine kinases participate in several signaling pathways through small G proteins such as Ras (rat sarcoma). An important component in the activation of these G proteins is Son of sevenless (SOS), which catalyzes the nucleotide exchange on Ras. For optimal activity, a second Ras molecule acts as an allosteric activator by binding to a second Ras-binding site within SOS. This allosteric ...
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