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- Rudge, David A., et al. Show all 7 Authors
- Tetrahedron letters 2012 v.53 no.38 pp. 5049-5055
- acrylamides; chemical reactions; chemical structure; nitrogen
- ... The development of a novel palladium-catalysed amidation approach towards 5,7,8,9-tetrahydropyrimido[4,5-b][1,4]diazepin-6-one templates is highlighted. The route proceeds through the reaction of an amino amide, generated by 1,4-addition of an amine to an acrylamide, with 5-bromo-2,4-dichloropyrimidine and final palladium-catalysed cyclisation to provide the functionalised scaffold in up to 60% is ...