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- Ruyken, Maartje, et al. Show all 5 Authors
- Molecular Immunology 2015 v.65 pp. 328-335
- Gram-negative bacteria; antibacterial properties; blood serum; complement; heat treatment; humans; immune system; vaccine development; viability
- ... Direct killing of Gram-negative bacteria by serum is usually attributed to the Membrane Attack Complex (MAC) that is assembled upon activation of the complement system. In serum bactericidal assays, the activity of the MAC is usually blocked by a relatively unspecific method in which certain heat-labile complement components are inactivated at 56°C. The goal of this study was to re-evaluate MAC-dr ...
- Ruyken, Maartje, et al. Show all 12 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.36 pp. 13187-13192
- Staphylococcus aureus; bacteria; crystallography; immune response; neutrophils; pathogenicity; proteinase inhibitors; proteins; serine proteinases
- ... Significance Neutrophils are among the first immune cells to migrate to the site of infection and clear invading bacteria. They store large amounts of neutrophil serine proteases (NSPs) that play key roles in immune defense. Unfortunately, NSPs also contribute to tissue destruction in a variety of inflammatory disorders. In this study we discover that the pathogenic bacterium Staphylococcus aureus ...
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