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1. A missense variant in the coil1A domain of the keratin 25 gene is associated with the dominant curly hair coat trait (Crd) in horse

Author:
Saintilan, Romain,   et al.   ; Morgenthaler, Caroline; Diribarne, Mathieu; Capitan, Aurélien; Legendre, Rachel; Gilles, Maïlys; Esquerré, Diane; Juras, Rytis; Khanshour, Anas; Schibler, Laurent; Cothran, Gus;     Show all 11 Authors
Source:
Genetics, selection, evolution 2017 v.49 no.1 pp. 85
ISSN:
1297-9686
Subject:
alleles; ears; genome-wide association study; genotyping; hairs; haplotypes; heterozygosity; keratin; loci; multigene family; pedigree; phenotype; sequence analysis; stallions; statistical models; tail
Abstract:
... BACKGROUND: Curly horses present a variety of curl phenotypes that are associated with various degrees of curliness of coat, mane, tail and ear hairs. Their origin is still a matter of debate and several genetic hypotheses have been formulated to explain the diversity in phenotype, including the combination of autosomal dominant and recessive alleles. Our purpose was to map the autosomal dominant ...
DOI:
10.1186/s12711-017-0359-5

2. Detection of quantitative trait loci for maternal traits using high-density genotypes of Blonde d’Aquitaine beef cattle

Author:
Saintilan, Romain,   et al.   ; Michenet, Alexis; Barbat, Marine; Venot, Eric; Phocas, Florence;     Show all 5 Authors
Source:
BMC genetics 2016 v.17 no.1 pp. 88
ISSN:
1471-2156
Subject:
beef cows; calving; cattle breeds; cattle production; chromosomes; dairy cattle; genes; genotype; genotyping; mastitis; maternal effect; milk yield; phenotype; production technology; quantitative trait loci; single nucleotide polymorphism; suckling; udders; vitamin D-binding protein; weaning weight
Abstract:
... BACKGROUND: The genetic determinism of the calving and suckling performance of beef cows is little known whereas these maternal traits are of major economic importance in beef cattle production systems. This paper aims to identify QTL regions and candidate genes that affect maternal performance traits in the Blonde d’Aquitaine breed. Three calving performance traits were studied: the maternal effe ...
DOI:
10.1186/s12863-016-0397-y
PubMed:
27328805
PubMed Central:
PMC4915167

3. Insights into the genetic variation of maternal behavior and suckling performance of continental beef cows

Author:
Saintilan, Romain,   et al.   ; Michenet, Alexis; Venot, Eric; Phocas, Florence;     Show all 4 Authors
Source:
Genetics, selection, evolution 2016 v.48 no.1 pp. 45
ISSN:
1297-9686
Subject:
animal models; beef cows; calves; calving; cattle breeds; genes; genetic correlation; genetic variation; genomics; genotype; genotyping; heritability; maternal behavior; milk yield; prediction; quantitative trait loci; suckling; udders
Abstract:
... BACKGROUND: In beef cattle, maternal care is critical for calf survival and growth. Our objective was to evaluate the major sources of additive genetic variation in maternal behavior and suckling performance in two genetically close beef breeds. METHODS: Maternal performance was assessed based on maternal behavior (MB), milk yield (MY) and udder swelling score (US) of 1236 Blonde d’Aquitaine cows ...
DOI:
10.1186/s12711-016-0223-z
PubMed:
27335091
PubMed Central:
PMC4918023

4. Multi-breed and multi-trait co-association analysis of meat tenderness and other meat quality traits in three French beef cattle breeds

Author:
Saintilan, Romain,   et al.   ; Ramayo-Caldas, Yuliaxis; Renand, Gilles; Ballester, Maria; Rocha, Dominique;     Show all 5 Authors
Source:
Genetics, selection, evolution 2016 v.48 no.1 pp. 37
ISSN:
1297-9686
Subject:
beef; beef cattle; beef quality; biochemical pathways; cattle breeds; gene frequency; genes; genetic heterogeneity; genome-wide association study; linkage disequilibrium; marker-assisted selection; meat tenderness; phenotype; phenotypic variation; quantitative trait loci; shear stress; single nucleotide polymorphism
Abstract:
... BACKGROUND: Studies to identify markers associated with beef tenderness have focused on Warner–Bratzler shear force (WBSF) but the interplay between the genes associated with WBSF has not been explored. We used the association weight matrix (AWM), a systems biology approach, to identify a set of interacting genes that are co-associated with tenderness and other meat quality traits, and shared acro ...
DOI:
10.1186/s12711-016-0216-y
PubMed:
27107817
PubMed Central:
PMC4842279

5. Whole-genome sequencing identifies a homozygous deletion encompassing exons 17 to 23 of the integrin beta 4 gene in a Charolais calf with junctional epidermolysis bullosa

Author:
Saintilan, Romain,   et al.   ; Michot, Pauline; Fantini, Oscar; Braque, Régis; Allais-Bonnet, Aurélie; Grohs, Cécile; Barbieri, Johanna; Genestout, Lucie; Danchin-Burge, Coralie; Gourreau, Jean-Marie; Boichard, Didier; Pin, Didier; Capitan, Aurélien;     Show all 13 Authors
Source:
Genetics, selection, evolution 2015 v.47 no.1 pp. 110
ISSN:
1297-9686
Subject:
screening; sequence analysis; epidermolysis bullosa; sires; haplotypes; humans; herds; DNA; integrins; heterozygosity; genotyping; Charolais; homozygosity; calves; exons; histopathology; single nucleotide polymorphism
Abstract:
... BACKGROUND: Since 2010, four Charolais calves with a congenital mechanobullous skin disorder that were born in the same herd from consanguineous matings were reported to us. Clinical and histopathological examination revealed lesions that are compatible with junctional epidermolysis bullosa (JEB). RESULTS: Fifty-four extended regions of homozygosity (>1 Mb) were identified after analysing the whol ...
DOI:
10.1186/s12711-015-0110-z
PubMed:
25935160
PubMed Central:
PMC4417276