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- Sakiyama, Haruhiko, et al. Show all 12 Authors
- Biochimica et biophysica acta 2019 v.1864 no.3 pp. 271-280
- adipocytes; caffeine; fatty liver; hepatocytes; hepatoprotective effect; interleukin-6; knockout mutants; liver; macrophages; messenger RNA; mice; muscles; myotubes; oxygen consumption; risk reduction
- ... Caffeine intake is associated with a reduced risk developing non-alcoholic fatty liver disease (NAFLD), but the underlying molecular mechanisms remain to be fully elucidated. We report here that caffeine markedly improved high fat diet-induced NAFLD in mice resulting in a 10-fold increase in circulating IL-6 levels, leading to STAT3 activation in the liver. Interestingly, the expression of IL-6 mR ...