Jump to Main Content
- Sato, Tatsuhiro, et al. Show all 6 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.9 pp. 3514-3519
- G-proteins; Schizosaccharomyces pombe; amino acids; genes; mammals; mutants; nutrients; point mutation; signal transduction; stress tolerance; toxicity
- ... Rheb is a unique member of the Ras superfamily GTP-binding proteins. We as well as others previously have shown that Rheb is a critical component of the TSC/TOR signaling pathway. In fission yeast, Rheb is encoded by the rhb1 gene. Rhb1p is essential for growth and directly interacts with Tor2p. In this article, we report identification of 22 single amino acid changes in the Tor2 protein that enab ...
- PubMed Central: