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- Satya Pratap, Veera Venkata Valluri, et al. Show all 6 Authors
- Analytical biochemistry 2018 v.545 pp. 78-83
- Western blotting; cell lines; colorectal neoplasms; drugs; enzyme activity; enzyme-linked immunosorbent assay; genes; pharmacodynamics; phosphorylation; phosphotransferases (kinases); recombinant fusion proteins; screening
- ... Tropomyosin-related kinase A (TRKA) fusion was originally detected in colorectal carcinoma that had resulted in expression of the oncogenic chimeric protein TPM3-TRKA. Lately, many more rearrangements in TRK family of kinases generating oncogenic fusion proteins have been identified. These genetic rearrangements usually result in fusion of cytoplasmic kinase domain of TRK to another gene of intere ...