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- Saura, Alicia, et al. Show all 7 Authors
- The international journal of biochemistry & cell biology 2016 v.81 pp. 32-43
- Giardia lamblia; acetylation; antigenic variation; encystment; epigenetics; eukaryotic cells; evolution; gene expression; histone deacetylase; histones; hosts; intestines; methylation; microorganisms; parasites; promoter regions; surface antigens; transcription (genetics); transcription factors; translation (genetics)
- ... During evolution, parasitic microorganisms have faced the challenges of adapting to different environments to colonize a variety of hosts. Giardia lamblia, a common cause of intestinal disease, has developed fascinating strategies to adapt both outside and inside its host’s intestine, such as trophozoite differentiation into cyst and the switching of its major surface antigens. How gene expression ...
- Saura, Alicia, et al. Show all 4 Authors
- Infection and immunity 2005 v.73 no.8 pp. 5208-5211
- Giardia lamblia; Giardia muris; antigenic variation; immune response; parasites; rodents; surface proteins; trophozoites
- ... Giardia lamblia undergoes antigenic variation, a process that might allow the parasite to evade the host's immune response and adapt to different environments. Here we show that Giardia muris, a related species that naturally infects rodents, possesses multiple variant-specific surface proteins (VSPs) and expresses VSPs on its surface, suggesting that it undergoes antigenic variation similar to th ...
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