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- Sausen, Mark, et al. Show all 18 Authors
- Science 2011 v.333 no.6048 pp. 1453-1455
- Drosophila; adults; binding proteins; brain; chromosomes; genes; humans; mutation; neoplasms; oligodendroglia
- ... Oligodendrogliomas are the second most common malignant brain tumor in adults and exhibit characteristic losses of chromosomes 1p and 19q. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven tumors. Among other changes, we found that the CIC gene (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six cases and that ...
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