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- Schilcher, Nicole, et al. Show all 15 Authors
- Journal of natural products 2016 v.79 no.6 pp. 1651-1657
- mechanism of action; messenger RNA; protein synthesis; proteome; atherosclerosis; cell viability; Leontopodium nivale; actinomycin D; humans; transporters; macrophages; polymerase chain reaction; Western blotting; cholesterol; transcription (genetics); lignans; half life
- ... Leoligin is a natural lignan found in Edelweiss (Leontopodium nivale ssp. alpinum). The aim of this study was to examine its influence on cholesterol efflux and to address the underlying mechanism of action. Leoligin increases apo A1- as well as 1% human plasma-mediated cholesterol efflux in THP-1 macrophages without affecting cell viability as determined by resazurin conversion. Western blot anal ...
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