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- Sharbrough, Joel, et al. Show all 4 Authors
- Trends in biotechnology 2018 v.36 pp. 729-740
- DNA damage; mutation; tissues
- ... There is a great need in biomedical and genetic research to detect DNA damage and de novo mutations, but doing so is inherently challenging because of the rarity of these events. The enormous capacity of current DNA sequencing technologies has opened the door for quantifying sequence variants present at low frequencies in vivo, such as within cancerous tissues. However, these sequencing technologi ...
- Sharbrough, Joel, et al. Show all 3 Authors
- Molecular ecology 2017 v.26 no.8 pp. 2212-2236
- coevolution; epistasis; gene flow; genes; haplotypes; introgression; mitochondria; mitochondrial DNA; mitochondrial genome; mutation; nuclear genome; reproductive isolation
- ... The study of reproductive isolation and species barriers frequently focuses on mitochondrial genomes and has produced two alternative and almost diametrically opposed narratives. On one hand, mtDNA may be at the forefront of speciation events, with co‐evolved mitonuclear interactions responsible for some of the earliest genetic incompatibilities arising among isolated populations. On the other han ...