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- Shreenivas, Meghanashree, et al. Show all 9 Authors
- Vaccine 2018 v.36 no.50 pp. 7715-7727
- Neisseria meningitidis; Salmonella Typhimurium; animal models; antibodies; blood serum; carbon metabolism; cytokines; enzymes; genes; humans; live vaccines; morbidity; mortality; neonates; pathogens; pregnancy; subunit vaccines; typhoid fever; vaccination; virulence; young adults
- ... Live attenuated vaccines are superior to the killed or subunit vaccines. We designed a Salmonella Typhimurium strain by deleting folD gene (encoding methylenetetrahydrofolate dehydrogenase-cyclohydrolase) in the presence of a heterologous fhs gene (encoding formyltetrahydrofolate synthetase) and tested its vaccine potential under stringent conditions of lethal and sub-lethal challenges with virule ...