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- Shyu, Huey-Wen, et al. Show all 12 Authors
- Food and chemical toxicology 2018 v.112 pp. 194-204
- Trifolium pratense; acetylcysteine; antioxidants; apoptosis; biochanin A; caspase-3; caspase-9; cell growth; chemoprevention; cytochrome c; cytotoxicity; dose response; doxorubicin; glutathione; humans; membrane potential; mitochondria; mitochondrial membrane; mitogen-activated protein kinase; osteosarcoma; phosphatidylserines; toxicology; vitamin E
- ... Biochanin A is a major isoflavone in red clover and a potent chemopreventive agent against cancer. However, the effects of biochanin A on human osteosarcoma cells have never been clarified. This study investigated the anti-proliferative potential of biochanin A in osteosarcoma cells. The results indicate that biochanin A inhibited cell growth and colony formation in a dose-dependent manner with a ...
- Shyu, Huey-Wen, et al. Show all 14 Authors
- Food and chemical toxicology 2016 v.97 pp. 336-345
- DNA damage; acetylcysteine; antineoplastic activity; apoptosis; benzyl isothiocyanate; beta-mercaptoethanol; catalase; cyclins; dithiothreitol; drugs; free radical scavengers; glutathione; humans; mannitol; membrane potential; mitochondrial membrane; mouth neoplasms; neoplasm cells; nitric oxide; reactive oxygen species; toxicity; toxicology
- ... Benzyl isothiocyanate (BITC) is a cruciferous vegetable-derived compound with anticancer properties in human cancer cells. However, its anticancer potential and underlying mechanisms remain absent in human oral cancer cells. Results indicate that BITC inhibits growth, promotes G2/M phase arrest and triggers apoptosis of OC2 cells with a minimal toxicity to normal cells. BITC-induced cell death was ...