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- Author:
- Singh, Karam Pal, et al. ; Prakash, Chandan; Kumar, Bablu; Singh, Rabindra Prasad; Singh, Praveen; Shrinet, Garima; Das, Aparajita; Ashmi, Marcia; Abhishek,; Singh, Mithilesh Kumar; Gupta, Vivek Kumar; Show all 11 Authors
- Source:
- Journal of microbiological methods 2021 v.184 pp. 106185
- ISSN:
- 0167-7012
- Subject:
- Brucella; brucellosis; cattle; cross reaction; herds; immunoassays; nanogold; reference standards; stomach
- Abstract:
- ... The widely used serodiagnostic test (RBPT, CFT, I-ELISA and FPA) for diagnosis of brucellosis cannot detect vertically infected or carrier animals that are seronegative, a persistent source of infection to other susceptible animals in the herd. For reducing transmission of disease within the herd, these animals must be detected using a rapid, sensitive, user friendly penside diagnostic test. In th ...
- DOI:
- 10.1016/j.mimet.2021.106185
- https://dx.doi.org/10.1016/j.mimet.2021.106185
- Author:
- Singh, Karam Pal, et al. ; Munuswamy, Palanivelu; Ramakrishnan, Saravanan; Latheef, Shyma K.; Kappala, Deepthi; Mariappan, Asok Kumar; Kaore, Megha; Anbazhagan, Karthikeyan; Puvvala, Bhavani; Dhama, Kuldeep; Show all 10 Authors
- Source:
- Microbial pathogenesis 2021 v.154 pp. 104830
- ISSN:
- 0882-4010
- Subject:
- ; Avastrovirus 2; Avian nephritis virus; Infectious bronchitis virus; RNA-directed RNA polymerase; genes; glycoproteins; histopathology; inflammation; interleukin-12; interleukin-13; interleukin-4; macrophages; mixed infection; necropsy; pathogenesis; viruses
- Abstract:
- ... We describe the first report on spontaneous Avian Nephritis Virus (ANV) and Infectious Bronchitis Virus (IBV) concurrent infection in broiler chicks. On necropsy, the kidneys were found swollen with its parenchyma and ureters stuffed with urate flakes. Histopathologically, the renal tubular damage and inflammatory response were severe in concurrently infected birds compared to the cases infected o ...
- DOI:
- 10.1016/j.micpath.2021.104830
- https://dx.doi.org/10.1016/j.micpath.2021.104830
- Author:
- Singh, Karam Pal, et al. ; Dhama, Kuldeep; Patel, Shailesh Kumar; Yatoo, Mohd Iqbal; Tiwari, Ruchi; Sharun, Khan; Dhama, Jaideep; Natesan, Senthilkumar; Malik, Yashpal Singh; Harapan, Harapan; Show all 10 Authors
- Source:
- Journal of environmental management 2021 v.280 pp. 111825
- ISSN:
- 0301-4797
- Subject:
- COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; environmental management; human population; monitoring; pandemic; public health; sanitation; sewage; virus transmission; viruses; wastewater; water supply
- Abstract:
- ... The SARS-CoV-2/COVID-19 pandemic has spread across the globe and affected millions of individuals as of the efficient virus transmission potential mediated via multiple virus shedding routes. The presence of SARS-CoV-2 in the stool samples and its prolonged shedding in environmental compartments like sewage and wastewater signifies a potential threat adding to the transmission cycle of this novel ...
- DOI:
- 10.1016/j.jenvman.2020.111825
- https://dx.doi.org/10.1016/j.jenvman.2020.111825
- Author:
- Singh, Karam Pal, et al. ; Kamdi, Bhupesh; Singh, Rajendra; Singh, Vidya; Singh, Shailendra; Kumar, Pawan; George, Neethu; Dhama, Kuldeep; Show all 8 Authors
- Source:
- Microbial pathogenesis 2020 v.145 pp. 104165
- ISSN:
- 0882-4010
- Subject:
- Bovine orthopneumovirus; Bovine respirovirus 3; antibodies; antigens; buffaloes; cattle; databases; edema; epidemiological studies; epithelium; financial economics; fluorescent antibody technique; hyperplasia; macrophages; necropsy; necrosis; pathogenesis; pneumocytes; pneumonia; reverse transcriptase polymerase chain reaction; sequence analysis; viruses; young animals; India
- Abstract:
- ... Pneumonia in bovines is a multifactorial disease manifestation leading to heavy economic losses. Infections of bovine respiratory syncytial virus (BRSV) and bovine parainfluenza virus-3 (BPI-3) are among the important contributing factors for the development of pneumonia in young animals. These viral agents either primarily cause pneumonia or predispose animals to the development of pneumonia. Alt ...
- DOI:
- 10.1016/j.micpath.2020.104165
- PubMed:
- 32205208
- PubMed Central:
- PMC7118649
- https://dx.doi.org/10.1016/j.micpath.2020.104165
- Author:
- Singh, Karam Pal, et al. ; Manjunatha Reddy, Gundallhalli Bayyappa; Krishnappa, Sumana; Vinayagamurthy, Balamurugan; Singh, Rajendra; Saminathan, Mani; Sajjanar, Basavaraj; Rahman, Habibur; Show all 8 Authors
- Source:
- Virusdisease 2018 v.29 no.3 pp. 362-368
- ISSN:
- 2347-3584
- Subject:
- quantitative polymerase chain reaction; sequence analysis; nucleoproteins; Rabies lyssavirus; zoonoses; humans; rabies; genome; dogs; brain; hosts; phylogeny; reverse transcriptase polymerase chain reaction; genotype; molecular epidemiology; wild animals; domestic animals; fluorescent antibody technique; India; Arctic region
- Abstract:
- ... Rabies is a neglected viral zoonotic disease affecting humans, domestic and wild animals and is endemic in most parts of the India. Dog mediated rabies is more predominant than other forms of rabies and molecular epidemiology is poorly understood in both reservoir and susceptible hosts. In the present study, a total of 140 rabies suspected brain samples from different species of animals from diffe ...
- DOI:
- 10.1007/s13337-018-0478-9
- PubMed:
- 30159372
- PubMed Central:
- PMC6111947
- https://dx.doi.org/10.1007/s13337-018-0478-9
- Author:
- Singh, Karam Pal, et al. ; Manjunatha, Venkataravanappa; Saminathan, Mani; Singh, Rajendra; Shivasharanappa, Nayakwadi; Umeshappa, Channakeshava Sokke; Dhama, Kuldeep; Manjunathareddy, Gundallahalli Bayyappa; Show all 8 Authors
- Source:
- Microbial pathogenesis 2017 v.112 pp. 38-49
- ISSN:
- 0882-4010
- Subject:
- T-lymphocytes; signal transduction; viral load; mitogen-activated protein kinase; immunity; correlation; immunohistochemistry; brain; spleen; viruses; pathogenesis; apoptosis; caspase-3; messenger RNA; lethal dose 50; blood serum; chemokine CXCL10; neurons; mice; tumor necrosis factor-alpha; natural killer cells; histopathology; mortality; fluorescent antibody technique; quantitative polymerase chain reaction; Rabies lyssavirus; nitric oxide; rabies; therapeutics; animal models; inducible nitric oxide synthase
- Abstract:
- ... The extracellular signal-regulated kinase (ERK) pathway has been shown to regulate pathogenesis of many viral infections, but its role during rabies virus (RV) infection in vivo is not clear. In the present study, we investigated the potential role of MEK-ERK1/2 signalling pathway in the pathogenesis of rabies in mouse model and its regulatory effects on pro-inflammatory cytokines and other mediat ...
- DOI:
- 10.1016/j.micpath.2017.09.044
- https://dx.doi.org/10.1016/j.micpath.2017.09.044
- Author:
- Singh, Karam Pal, et al. ; Khuman, Maibam Wanta; Harikumar, Sankaran Kutty; Sadam, Abdul; Kesavan, Manickam; Susanth, Vattaparambil Sukumaran; Parida, Subhashree; Sarkar, Souvendra Nath; Show all 8 Authors
- Source:
- Toxicology 2016 v.374 pp. 29-41
- ISSN:
- 0300-483X
- Subject:
- Western blotting; angiotensin II; aorta; arsenic; atherosclerosis; blood; blood pressure; collagen; enzyme-linked immunosorbent assay; hydroxyproline; hypertension; immunohistochemistry; mitogen-activated protein kinase; rats; receptors; signal transduction; sodium arsenite; staining; transforming growth factor beta
- Abstract:
- ... Arsenic exposure can cause several cardiovascular diseases, including hypertension, atherosclerosis and microvascular disease. Earlier, we reported that arsenic-mediated enhancement of angiotensin II (AngII) signaling can impair vascular physiology. Here, we investigated whether the AT1 receptor (AT1R) blocker candesartan can ameliorate the arsenic-induced hypertensive vascular remodeling in rats ...
- DOI:
- 10.1016/j.tox.2016.11.015
- http://dx.doi.org/10.1016/j.tox.2016.11.015
- Author:
- Singh, Karam Pal, et al. ; Umeshappa, Channakeshava Sokke; Nanjundappa, Roopa Hebbandi; Channappanavar, Rudragouda; Maan, Sushila; Maan, Narender S.; Show all 6 Authors
- Source:
- Veterinary research communications 2012 v.36 no.4 pp. 245-250
- ISSN:
- 0165-7380
- Subject:
- Bluetongue virus; RNA; antigens; experimental design; in vivo studies; lesions (animal); mononuclear leukocytes; nitric oxide; nitric oxide synthase; sheep; virus replication
- Abstract:
- ... Mononuclear leukocytes of peripheral blood mononuclear cells (PBMCs) and regional lymphoid organs (RLOs) play a critical role in primary BTV replication and subsequent viral dissemination to distant systemic organs. The lesions in animals develop primarily as a result of vascular insult, presumably induced by the activity of viral and/or proinflammatory vasoactive mediators. Hence, the current stu ...
- DOI:
- 10.1007/s11259-012-9538-6
- PubMed:
- 23007876
- http://dx.doi.org/10.1007/s11259-012-9538-6
- Author:
- Singh, Karam Pal, et al. ; Mertens, Peter P. C.; Maan, Narender S.; Belaganahalli, Manjunatha N.; Nomikou, Kyriaki; Maan, Sushila; Show all 6 Authors
- Source:
- Genome announcements 2013 v.1 no.5 pp. e00684-13
- ISSN:
- 2169-8287
- Subject:
- Bluetongue virus; genome; nucleotide sequences; serotypes; Nigeria
- Abstract:
- ... The genome of NIG1982/10, a Nigerian bluetongue virus serotype 16 (BTV-16) strain, was sequenced (19,193 bp). Comparisons to BTV strains from other areas of the world show that all 10 genome segments of NIG1982/10 are derived from a western lineage (w), indicating that it represents a suitable reference strain of BTV-16w. ...
- DOI:
- 10.1128/genomeA.00684-13
- PubMed:
- 24051311
- PubMed Central:
- PMC3778194
- http://dx.doi.org/10.1128/genomeA.00684-13
- Author:
- Singh, Karam Pal, et al. ; Umeshappa, Channakeshava Sokke; Ahmed, Khawaja Ashfaque; Pandey, Awadh Bihari; Nanjundappa, Roopa Hebbandi; Show all 5 Authors
- Source:
- Research in veterinary science 2011 v.90 no.2 pp. 212-214
- ISSN:
- 0034-5288
- Subject:
- Bluetongue virus; antigens; bluetongue; cell-mediated immunity; gene expression; interferon-gamma; interleukin-12; interleukin-2; messenger RNA; mononuclear leukocytes; sheep; sheep diseases; vaccination; vaccine development
- Abstract:
- ... Bluetongue (BT), a serious disease of sheep and some wild ruminants, is caused by bluetongue virus (BTV), a member of the family, Reoviridae. The current research thrust for controlling BT is on development of efficient vaccines, necessitating clear understanding of ovine immunology. At present, comparative studies on cytokine gene expression profiles of naïve and BTV-sensitized peripheral blood m ...
- DOI:
- 10.1016/j.rvsc.2010.05.034
- PubMed:
- 21349379
- http://dx.doi.org/10.1016/j.rvsc.2010.05.034
- Author:
- Singh, Karam Pal, et al. ; Umeshappa, Channakeshava Sokke; Nanjundappa, Roopa Hebbandi; Pandey, Awadh Bihari; Show all 4 Authors
- Source:
- Veterinary microbiology 2010 v.144 no.3-4 pp. 310-318
- ISSN:
- 0378-1135
- Subject:
- DNA damage; bacterial pneumonia; disease course; Bluetongue virus; immunosuppression; sheep; monocytes; Pasteurella; animal pathogenic bacteria; sheep diseases; spleen; bluetongue; interferons; pathogenesis; apoptosis; signs and symptoms (animals and humans); caspase-3
- Abstract:
- ... The role of apoptosis in pathogenesis of bluetongue (BT) has been suggested from various in vitro studies. However, to date, no clear data are available regarding BTV-induced apoptosis and its consequences in natural host, sheep. In the present study, bluetongue virus (BTV)-induced apoptosis was studied in sheep blood and splenic mononuclear cells by analyzing annexin⁺-propidium iodide⁻ early apop ...
- DOI:
- 10.1016/j.vetmic.2010.02.033
- http://dx.doi.org/10.1016/j.vetmic.2010.02.033
- Author:
- Singh, Karam Pal, et al. ; Umeshappa, Channakeshava Sokke; Channappanavar, Rudragouda; Sharma, Kavita; Nanjundappa, Roopa Hebbandi; Saxena, Meeta; Singh, Rajendra; Sharma, Anil Kumar; Show all 8 Authors
- Source:
- Veterinary immunology and immunopathology 2011 v.141 no.3-4 pp. 230-238
- ISSN:
- 0165-2427
- Subject:
- Bluetongue virus; antibodies; bluetongue; humoral immunity; immune response; intravenous injection; lungs; lymph nodes; pathogenesis; pulmonary artery; serotypes; sheep; spleen; viruses
- Abstract:
- ... The pathogenesis of bluetongue (BT) could vary with route of inoculation. Using laboratory-passaged moderately virulent bluetongue virus serotype 23 (BTV-23), one of the most prevalent Indian serotype, we investigated the pathogenesis of BT in intradermally (ID) and intravenously (IV) inoculated native sheep. The ID inoculation resulted in relatively increased clinical signs and lesions in many or ...
- DOI:
- 10.1016/j.vetimm.2011.03.005
- PubMed:
- 21511346
- http://dx.doi.org/10.1016/j.vetimm.2011.03.005
- Author:
- Singh, Karam Pal, et al. ; Maan, Sushila; Maan, Narender S.; Belaganahalli, Manjunatha N.; Kumar, Aman; Batra, Kanisht; Rao, Pavuluri Panduranga; Hemadri, Divakar; Reddy, Yella Narasimha; Putty, Kalyani; Krishnajyothi, Yadlapati; Reddy, G. Hanmanth; Hegde, Nagendra R.; Nomikou, Kyriaki; Sreenivasulu, Daggupati; Mertens, Peter P. C.; Show all 16 Authors
- Source:
- Genome Announcements 2015 v.3 no.2 pp. e00045-15
- ISSN:
- 2169-8287
- Subject:
- Bluetongue virus; coat proteins; genes; nucleotide sequences; serotypes; India; South Africa; United States
- Abstract:
- ... Southern Indian isolate IND1994/01 of bluetongue virus serotype 2 (BTV-2), from the Orbivirus Reference Collection at the Pirbright Institute (http://www.reoviridae.org/dsRNA_virus_proteins/ReoID/btv-2.htm#IND1994/01), was sequenced. Its genome segment 6 (Seg-6) [encoding VP5(OCP2)] is identical to that of the Indian BTV-1 isolate (IND2003/05), while Seg-5 and Seg-9 are closely related to isolates ...
- DOI:
- 10.1128/genomeA.00045-15
- PubMed:
- 25858823
- PubMed Central:
- PMC4392135
- http://dx.doi.org/10.1128/genomeA.00045-15