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- Soares, HugoR., et al. Show all 5 Authors
- Biotechnology letters 2018 v.40 no.4 pp. 633-639
- Gammaretrovirus; cell lines; gene expression; proteins; research and development; transgenes
- ... OBJECTIVE: Develop an engineered cell line containing two flexible gene expression systems enabling the continuous production of tailor-made recombinant gammaretrovirus with predictable productivities through targeted integration. RESULTS: Dual-FLEX cells (dFLEX) contain two independent recombinase-mediated cassette exchange (RMCE) systems which confer flexibility to the expression of different tr ...