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1. The involvement of PyBeclin 1 and PyLC3 in regulating the activation of autophagy in scallop Patinopecten yessoensis after acute high temperature stress

Author:
Song, Linsheng,   et al.   ; Shan, Ying; Yang, Chuanyan; Guo, Xiaoxiao; Sun, Jiejie; He, Zhaoyu; Jiang, Dongli; Yang, Wenwen; Wang, Lingling;     Show all 9 Authors
Source:
Developmental and comparative immunology 2021 v.121 pp. 104093
ISSN:
0145-305X
Subject:
Mizuhopecten yessoensis; amino acids; autophagy; cytoplasm; gene expression; heat stress; hemocytes; immunology; muscles; polypeptides; scallops; temperature
Abstract:
... Beclin 1 and LC3 are important autophagy regulation proteins involved in vesicle nucleation and extension stage, respectively. In the present study, a Beclin 1 and a LC3 were identified from Yesso scallop Patinopecten yessoensis (PyBeclin 1 and PyLC3). The open reading frame (ORF) of PyBeclin 1 was of 1335 bp encoding a putative polypeptide of 444 amino acid residues with an N-terminal BCL-2 homol ...
DOI:
10.1016/j.dci.2021.104093

2. The DNA cytosine-5-methyltransferase 3 (DNMT3) involved in regulation of CgIL-17 expression in the immune response of oyster Crassostrea gigas

Author:
Song, Linsheng,   et al.   ; Zhao, Qi; Wang, Weilin; Li, Jia xin; Yuan, Pei; Liu, Yu; Li, Yan; Wang, Lingling;     Show all 8 Authors
Source:
Developmental and comparative immunology 2021 pp. 104092
ISSN:
0145-305X
Subject:
; 5-methylcytosine; Crassostrea gigas; DNA; DNA methylation; DNA methyltransferase; Vibrio splendidus; amino acids; cytokines; cytoplasm; genomics; hemocytes; immune response; muscles; oysters; transposons
Abstract:
... DNA methyltransferase, a key enzyme mediating DNA methylation, is involved in numerous processes including genomic imprinting, X chromosome inactivation, transposable element suppression, and immune defense in vertebrates. In the present study, a DNA cytosine-5-methyltransferase 3 was identified from oyster Crassostrea gigas (designed as CgDNMT3). There were a PWWP domain, a PHD domain and a DNA-m ...
DOI:
10.1016/j.dci.2021.104092

3. An insulin-like peptide serves as a regulator of glucose metabolism in the immune response of Chinese mitten crab Eriocheir sinensis

Author:
Song, Linsheng,   et al.   ; Wang, Lin; Chen, Hao; Wang, Lingling;     Show all 4 Authors
Source:
Developmental and comparative immunology 2020 v.108 pp. 103686
ISSN:
0145-305X
Subject:
Aeromonas hydrophila; Eriocheir sinensis; crabs; cysteine; glucose; hemocytes; hepatopancreas; immune response; insulin; messenger RNA; metabolism; pathogens; polypeptides; somatomedins; thoracic ganglia; vertebrates
Abstract:
... A robust immune response against invading pathogens greatly depends on the balance of metabolism, which could be vigorously modulated by insulin/IGF signaling (IIS) pathway in vertebrates. However, knowledge on the IIS pathway, especially the function of insulin-like peptides (ILPs) in invertebrates remained largely unknown. In the present study, a novel ILP was identified from Eriocheir sinensisi ...
DOI:
10.1016/j.dci.2020.103686

4. A novel Adiponectin receptor (AdipoR) involved in regulating cytokines production and apoptosis of haemocytes in oyster Crassostrea gigas

Author:
Song, Linsheng,   et al.   ; Ge, Wenjing; Huang, Shu; Liu, Shujing; Sun, Jiejie; Liu, Zhaoqun; Yang, Wenwen; Wang, Lingling;     Show all 8 Authors
Source:
Developmental and comparative immunology 2020 v.110 pp. 103727
ISSN:
0145-305X
Subject:
B-lymphocytes; Crassostrea gigas; Vibrio splendidus; adiponectin; adiponectin receptors; amino acid sequences; amino acids; apoptosis; calcium; complementary DNA; gene expression; gene expression regulation; hemocytes; hepatopancreas; immune response; interleukins; lipopolysaccharides; messenger RNA; oysters; polyinosinic-polycytidylic acid; polypeptides; transfection; vertebrates
Abstract:
... Adiponectin receptors (AdipoRs) comprise a seven-transmembrane domain-containing protein family, which specifically recognize adiponectin (APN) and play critical roles in the immunological and physiological processes in vertebrates. In the present study, a novel AdipoR is identified from oyster Crassostrea gigas (designated as CgAdipoR). The full-length cDNA of CgAdipoR is of 1209 bp encoding a po ...
DOI:
10.1016/j.dci.2020.103727

5. The involvement of a regucalcin in suppressing hemocyte apoptosis in Pacific oyster Crassostrea gigas

Author:
Song, Linsheng,   et al.   ; Lian, Xingye; Huang, Shu; Han, Shuo; Yi, Qilin; Wang, Weilin; Sun, Jiejie; Wang, Lingling;     Show all 8 Authors
Source:
Fish & shellfish immunology 2020 v.103 pp. 229-238
ISSN:
1050-4648
Subject:
Crassostrea gigas; amino acid sequences; amino acids; apoptosis; calcium; caspase-3; complementary DNA; enzyme activity; genome; gills; hemocytes; hepatopancreas; homeostasis; immune response; lipopolysaccharides; messenger RNA; nitric oxide; open reading frames; oysters; tissues
Abstract:
... Regucalcin (RGN), also known as senescence marker protein-30 (SMP30), plays a vital role in the regulation of Ca²⁺ homeostasis. In the present study, a regucalcin (designated as CgRGN) was identified from Pacific oyster Crassostrea gigas. The complete cDNA sequence of CgRGN was of 1059 bp, containing an open reading frame of 933 bp which encoded a protein of 310 amino acids. The deduced amino acid ...
DOI:
10.1016/j.fsi.2020.05.002

6. The effects of protein kinase A catalytic subunit on sperm motility regulation in Pacific abalone Haliotis discus hannai

Author:
Song, Linsheng,   et al.   ; Kong, Ning; Li, Huan; Yang, Wen; Fu, Qiang; Gong, Changhao; Wang, Lingling;     Show all 7 Authors
Source:
Aquaculture research 2020 v.51 no.6 pp. 2525-2534
ISSN:
1355-557X
Subject:
Echinodermata; Haliotis discus hannai; Western blotting; abalone; acrosome; amino acids; cAMP-dependent protein kinase; catalytic activity; gene expression; hepatopancreas; messenger RNA; open reading frames; peptides; phosphorylation; phylogeny; protein subunits; sequence homology; sperm motility; tissues
Abstract:
... Protein kinase A plays a central role in the regulation of sperm motility from echinoderms to mammals, but the information about its regulatory role in molluscs is very limited. In this study, a protein kinase A catalytic subunit (designated as HdPKA‐C) was identified from Pacific abalone Haliotis discus hannai. The open reading frame of HdPKA‐C was of 1,077 bp, encoding a peptide of 358 amino aci ...
DOI:
10.1111/are.14595

7. A membrane-bound dopamine β-hydroxylase highly expressed in granulocyte of Pacific oyster Crassostrea gigas

Author:
Song, Linsheng,   et al.   ; Li, Meijia; Dong, Miren; Wang, Weilin; Li, Huan; Liu, Zhaoqun; Wang, Lingling; Wang, Kejian;     Show all 8 Authors
Source:
Developmental and comparative immunology 2020 v.104 pp. 103563
ISSN:
0145-305X
Subject:
Aplysia californica; Crassostrea gigas; Homo sapiens; Mus musculus; amino acid sequences; dopamine; dopamine beta-monooxygenase; endoplasmic reticulum; enzyme activity; genes; granules; granulocytes; hemocytes; immune response; immunocytes; messenger RNA; neurons; norepinephrine; oysters; phylogeny; recombinant proteins; vertebrates
Abstract:
... Dopamine β-hydroxylase (DBH) is one of key rate-limiting enzymes converting dopamine to norepinephrine. It locates not only in catecholaminergic neuron system, but also in immunocytes and plays roles in the immune response of vertebrates. However, the knowledge about the function of DBH in immune system is still very limited in invertebrates. In the present study, the DBH gene family with seven me ...
DOI:
10.1016/j.dci.2019.103563

8. A novel tumor necrosis factor in the Pacific oyster Crassostrea gigas mediates the antibacterial response by triggering the synthesis of lysozyme and nitric oxide

Author:
Song, Linsheng,   et al.   ; Zheng, Yan; Liu, Zhaoqun; Wang, Lingling; Li, Meijia; Zhang, Yukun; Zong, Yanan; Li, Yinan;     Show all 8 Authors
Source:
Fish & shellfish immunology 2020 v.98 pp. 334-341
ISSN:
1050-4648
Subject:
Crassostrea gigas; Crassostrea hongkongensis; Mizuhopecten yessoensis; Vibrio splendidus; amino acid sequences; amino acids; antibacterial properties; apoptosis; blood serum; enzyme activity; epithelium; hemocytes; humans; lipopolysaccharides; lysozyme; messenger RNA; nitric oxide; open reading frames; oysters; peptidoglycans; phagocytosis; phylogeny; polypeptides; recombinant proteins; scallops; tumor necrosis factor-alpha
Abstract:
... Tumor necrosis factors (TNFs) are a group of multifunctional inflammatory cytokines involved in various pathological and immune processes. Recently, a few primitive TNFs have been characterized from molluscs, which play important roles in modulating cell apoptosis, phagocytosis and production of immune-related enzymes. In the present study, a novel TNF (named as CgTNF-2) with the activity to media ...
DOI:
10.1016/j.fsi.2019.12.073

9. CgRel involved in antibacterial immunity by regulating the production of CgIL17s and CgBigDef1 in the Pacific oyster Crassostrea gigas

Author:
Song, Linsheng,   et al.   ; Li, Yinan; Sun, Jiejie; Zhang, Yukun; Wang, Min; Wang, Lingling;     Show all 6 Authors
Source:
Fish & shellfish immunology 2020 v.97 pp. 474-482
ISSN:
1050-4648
Subject:
Crassostrea gigas; RNA interference; Vibrio splendidus; bacteria; complementary DNA; cytoplasm; ganglia; gene expression; gills; hemocytes; hepatopancreas; immune response; innate immunity; lipopolysaccharides; messenger RNA; muscles; oysters; palps; tissues; transcription factor NF-kappa B
Abstract:
... The NF-κB/Rel transcription factors play essential roles in the induction and regulation of innate immune responses. In the present study, the full-length cDNA of CgRel from the Pacific oyster Crassostrea gigas was of 2,647 bp with an RHD and an IPT domain. The mRNA of CgRel was found to be constitutively expressed in all the tested tissues including gills, hepatopancreas, gonad, adductor muscle, ...
DOI:
10.1016/j.fsi.2019.11.036

10. The involvement of TLR signaling and anti-bacterial effectors in enhanced immune protection of oysters after Vibrio splendidus pre-exposure

Author:
Song, Linsheng,   et al.   ; Wang, Weilin; Wang, Lingling; Liu, Zhaoqun; Song, Xiaorui; Yi, Qilin; Yang, Chuanyan;     Show all 7 Authors
Source:
Developmental and comparative immunology 2020 v.103 pp. 103498
ISSN:
0145-305X
Subject:
Crassostrea gigas; Vibrio splendidus; apoptosis; cathepsins; endocytosis; enzyme inhibitors; gene expression regulation; genes; hemocytes; immune response; innate immunity; metalloproteinases; mitogen-activated protein kinase; oysters; pathogens; reverse transcriptase polymerase chain reaction; signal transduction; transcriptomics; transmembrane proteins
Abstract:
... The phenomena of enhanced protection of innate immunity responding to a pre-exposed pathogen have been reported in invertebrates. The underpinning molecular basis and mechanism for the enhanced immune protection are still missing. In order to explore the possible molecular basis for enhanced immune protection in molluscs, the transcriptomic analysis of oysters Crassostrea gigas hemocytes after twi ...
DOI:
10.1016/j.dci.2019.103498

11. A tandem-repeat galectin-1 from Apostichopus japonicus with broad PAMP recognition pattern and antibacterial activity

Author:
Song, Linsheng,   et al.   ; Zhang, Chi; Xue, Zhuang; Yu, Zichao; Wang, Hui; Liu, Yu; Li, Huan; Wang, Lingling; Li, Chenghua;     Show all 9 Authors
Source:
Fish & shellfish immunology 2020 v.99 pp. 167-175
ISSN:
1050-4648
Subject:
Apostichopus japonicus; Escherichia coli; Gram-negative bacteria; Gram-positive bacteria; Komagataella pastoris; Mesocentrotus; Micrococcus luteus; Paracentrotus lividus; Vibrio splendidus; amino acid sequences; amino acids; antibacterial properties; carbohydrate binding; coelomocytes; digestive system; fish; fungi; galactose; galectins; gene expression; inflammation; integument; invertebrates; lipopolysaccharides; mannose; messenger RNA; muscles; open reading frames; pathogens; peptidoglycans; phylogeny; polypeptides; recombinant proteins; respiratory system
Abstract:
... Galectins belong to the family of carbohydrate-binding proteins and play major roles in the immune and inflammatory responses of both vertebrates and invertebrates. In the present study, one novel galectin-1 protein named AjGal-1 was identified from Apostichopus japonicas with an open reading frame of 1179 bp encoding a polypeptide of 392 amino acids. The deduced amino acids sequence of AjGal-1 co ...
DOI:
10.1016/j.fsi.2020.02.011

12. AP-1 regulates the expression of IL17-4 and IL17-5 in the pacific oyster Crassostrea gigas

Author:
Song, Linsheng,   et al.   ; Wang, Liyan; Sun, Jiejie; Wu, Zhaojun; Lian, Xingye; Han, Shuo; Huang, Shu; Yang, Chuanyan; Wang, Lingling;     Show all 9 Authors
Source:
Fish & shellfish immunology 2020 v.97 pp. 554-563
ISSN:
1050-4648
Subject:
Crassostrea gigas; Crassostrea hongkongensis; amino acids; bacterial infections; gene expression; gene expression regulation; genes; granulocytes; hemocytes; immune response; leucine zipper; lipopolysaccharides; messenger RNA; oysters; phylogeny; tissues
Abstract:
... The activator protein-1 (AP-1) plays an important role in inducing the immune effector production in response to cellular stress and bacterial infection. In the present study, an AP-1 was identified from Pacific oyster Crassostrea gigas (designed as CgAP-1) and its function was investigated in response against lipopolysaccharide (LPS) stimulation. CgAP-1 was consisted of 290 amino acids including ...
DOI:
10.1016/j.fsi.2019.12.080

13. The oyster immunity

Author:
Song, Linsheng,   et al.   ; Wang, Lingling; Song, Xiaorui;     Show all 3 Authors
Source:
Developmental and comparative immunology 2018 v.80 pp. 99-118
ISSN:
0145-305X
Subject:
Crassostrea gigas; antimicrobial peptides; apoptosis; aquaculture; autophagy; common names; ecosystems; encapsulation; evolution; genes; hematopoiesis; hemocytes; immune response; immune system; immunomodulation; models; neuropeptides; oysters; signal transduction
Abstract:
... Oysters, the common name for a number of different bivalve molluscs, are the worldwide aquaculture species and also play vital roles in the function of ecosystem. As invertebrate, oysters have evolved an integrated, highly complex innate immune system to recognize and eliminate various invaders via an array of orchestrated immune reactions, such as immune recognition, signal transduction, synthesi ...
DOI:
10.1016/j.dci.2017.05.025

14. The sensing pattern and antitoxic response of Crassostrea gigas against extracellular products of Vibrio splendidus

Author:
Song, Linsheng,   et al.   ; Wang, Weilin; Lv, Xiaojing; Liu, Zhaoqun; Song, Xiaorui; Yi, Qilin; Wang, Lingling;     Show all 7 Authors
Source:
Developmental and comparative immunology 2019
ISSN:
0145-305X
Subject:
Crassostrea gigas; Vibrio splendidus; adults; animal diseases; antioxidants; apoptosis; blood proteins; disease control; enzyme activity; enzyme inhibitors; heat inactivation; hemocytes; humoral immunity; immune response; juveniles; metalloproteinases; oysters; pathogens; phagocytosis; polyacrylamide gel electrophoresis; reverse transcriptase polymerase chain reaction; virulence
Abstract:
... Serious juvenile oyster disease induced by pathogenic Vibrio splendidus has resulted in tremendous economic loss, but the molecular mechanisms underlying this killing mechanism remain unclear. The resistance of adult oyster to V. splendidus or its virulence factors might provide a possible access to cognize the interaction between pathogen and host. In the present study, the extracellular products ...
DOI:
10.1016/j.dci.2019.103467

15. ATG10 (autophagy-related 10) regulates the formation of autophagosome in the anti-virus immune response of pacific oyster (Crassostrea gigas)

Author:
Song, Linsheng,   et al.   ; Han, Zirong; Wang, Weilin; Lv, Xiaojing; Zong, Yanan; Liu, Shujing; Liu, Zhaoqun; Wang, Lingling;     Show all 8 Authors
Source:
Fish & shellfish immunology 2019 v.91 pp. 325-332
ISSN:
1050-4648
Subject:
Crassostrea gigas; Crassostrea virginica; Octopodidae; amino acids; autophagy; cell viability; complementary DNA; double-stranded RNA; gene expression; gene expression regulation; gills; hemocytes; hepatopancreas; immune response; interferon regulatory factors; interferons; messenger RNA; open reading frames; oysters; polypeptides; shellfish
Abstract:
... Autophagy, a highly conserved intracellular degradation system, is involved in numerous processes in vertebrate and invertebrate, such as cell survival, ageing, and immune responses. However, the detailed molecular mechanism of autophagy and its immune regulatory role in bivalves are still not well understood. In the present study, an autophagy-related protein ATG10 (designated as CgATG10) was ide ...
DOI:
10.1016/j.fsi.2019.05.027

16. Diversity and annual variation of phytoplankton community in Yesso scallop (Patinopecten yessoensis) farming waters of North Yellow Sea of China

Author:
Song, Linsheng,   et al.   ; Yu, Zichao; Liu, Chao; Wang, Feifei; Xue, Zhuang; Zhang, Anguo; Lu, Guangxia; Wang, Lingling;     Show all 8 Authors
Source:
Aquaculture 2019 pp. 734266
ISSN:
0044-8486
Subject:
Bacillariophyceae; Chlorophyta; Chrysophyceae; Dinophyceae; Mizuhopecten yessoensis; Noctilucales; algae; community structure; dissolved oxygen; energy; farming systems; grazing intensity; high-throughput nucleotide sequencing; mollusc culture; mortality; phytoplankton; ribosomal DNA; scallops; seawater; silicates; summer; temperature; China; Japan; Yellow Sea
Abstract:
... Yesso scallop (Patinopecten yessoensis) is one of the most important maricultured scallops in northern China, which was first introduced from Japan in 1980s. However, with the rapid development of aquaculture, the frequent occurrence of Yesso scallop's high mortality in summer has led to huge production losses. In the present study, seawater samples were collected from Yesso scallop farming waters ...
DOI:
10.1016/j.aquaculture.2019.734266

17. A new member of the runt domain family from Pacific oyster Crassostrea gigas (CgRunx) potentially involved in immune response and larvae hematopoiesis

Author:
Song, Linsheng,   et al.   ; Song, Xiaorui; Song, Ying; Dong, Miren; Liu, Zhaoqun; Wang, Weilin; Wang, Lingling;     Show all 7 Authors
Source:
Fish & shellfish immunology 2019 v.89 pp. 228-236
ISSN:
1050-4648
Subject:
Crassostrea gigas; Vibrio splendidus; amino acids; cell nucleus; fluorescent antibody technique; gene expression regulation; gills; hematopoiesis; hemocytes; immune response; larvae; messenger RNA; oysters; polypeptides; shellfish; transcription factors
Abstract:
... The Runx family is a kind of heteromeric transcription factors, which is defined by the presence of a runt domain. As transcriptional regulator during development and cell fate specification, Runx is best known for its critical roles in hematopoiesis. In the present study, a Runx transcription factor (designed as CgRunx) was identified and characterized from the oyster Crassostrea gigas. The compl ...
DOI:
10.1016/j.fsi.2019.03.066

18. A SPRY domain-containing SOCS box protein 3 (SPSB3) involved in the regulation of cytokine production in granulocytes of Crassostrea gigas

Author:
Song, Linsheng,   et al.   ; Wang, Min; Liu, Chang; Wang, Weilin; Dong, Miren; Zhang, Peng; Liu, Yu; Wang, Lingling;     Show all 8 Authors
Source:
Developmental and comparative immunology 2019 v.95 pp. 28-37
ISSN:
0145-305X
Subject:
Crassostrea gigas; RNA interference; Vibrio splendidus; amino acids; cell growth; cytokines; cytoplasm; fluorescent antibody technique; gene expression; genes; granulocytes; hemocytes; lipopolysaccharides; messenger RNA; open reading frames; oysters; polypeptides; tissues
Abstract:
... The sp1A/ryanodine receptor (SPRY) family members have been reported to involve in important biological pathways, including innate immune signaling, cytokine signaling suppression, development, cell growth, and retroviral restriction. In the present study, a SPRY domain-containing SOCS box protein (named as CgSPSB3) was identified and characterized from oyster Crassostrea gigas. The open reading f ...
DOI:
10.1016/j.dci.2019.01.013

19. The lectin domain containing proteins with mucosal immunity and digestive functions in oyster Crassostrea gigas

Author:
Song, Linsheng,   et al.   ; Wang, Weilin; Gong, Changhao; Han, Zirong; Lv, Xiaojing; Liu, Shujing; Wang, Lingling;     Show all 7 Authors
Source:
Fish & shellfish immunology 2019 v.89 pp. 237-247
ISSN:
1050-4648
Subject:
Crassostrea gigas; carbohydrate binding; complement; enzyme activity; enzymes; epidermal growth factor; lectins; males; mucosal immunity; oysters; receptors; recombinant fusion proteins; shellfish; surveys
Abstract:
... Lectins are carbohydrate-binding proteins with lectin domains, which are extensively studied for their numerous roles in biological recognition. However, the lectin domain containing proteins (LDCPs) chimerized with other non-lectin domains have not received sufficient attention. In the present study, a genome-wide survey of LDCPs in oyster Crassostrea gigas was conducted, and an expansive 640 LDC ...
DOI:
10.1016/j.fsi.2019.03.067

20. The immunomodulatory function of invertebrate specific neuropeptide FMRFamide in oyster Crassostrea gigas

Author:
Song, Linsheng,   et al.   ; Li, Meijia; Wang, Min; Wang, Weilin; Wang, Lingling; Liu, Zhaoqun; Sun, Jiejie; Wang, Kejian;     Show all 8 Authors
Source:
Fish & shellfish immunology 2019 v.88 pp. 480-488
ISSN:
1050-4648
Subject:
Crassostrea gigas; cytokines; ganglia; gene expression; gene expression regulation; genes; hemocytes; hepatopancreas; homeostasis; immune response; immunocytochemistry; immunohistochemistry; immunomodulators; lipopolysaccharides; messenger RNA; mitogen-activated protein kinase; muscles; neuropeptides; nitric oxide; oysters; pathogens; phosphorylation; phylogeny; shellfish
Abstract:
... As one of the most important neuropeptides identified only in invertebrates of Mollusca, Annelida and Arthropoda, FMRFamide (Phe-Met-Arg-Phe-NH2) involves in multiple physiological processes, such as mediating cardiac frequency and contraction of somatic and visceral muscles. However, its modulatory role in the immune defense has not been well understood. In the present study, an FMRFamide precurs ...
DOI:
10.1016/j.fsi.2019.03.023