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- Author:
- Song, Linsheng, et al. ; Wang, Lingling; Song, Xiaorui; Show all 3 Authors
- Source:
- Developmental and comparative immunology 2018 v.80 pp. 99-118
- ISSN:
- 0145-305X
- Subject:
- Crassostrea gigas; antimicrobial peptides; apoptosis; aquaculture; autophagy; common names; ecosystems; encapsulation; evolution; genes; hematopoiesis; hemocytes; immune response; immune system; immunomodulation; models; neuropeptides; oysters; signal transduction
- Abstract:
- ... Oysters, the common name for a number of different bivalve molluscs, are the worldwide aquaculture species and also play vital roles in the function of ecosystem. As invertebrate, oysters have evolved an integrated, highly complex innate immune system to recognize and eliminate various invaders via an array of orchestrated immune reactions, such as immune recognition, signal transduction, synthesi ...
- DOI:
- 10.1016/j.dci.2017.05.025
- https://dx.doi.org/10.1016/j.dci.2017.05.025
- Author:
- Song, Linsheng, et al. ; Han, Zirong; Wang, Weilin; Lv, Xiaojing; Zong, Yanan; Liu, Shujing; Liu, Zhaoqun; Wang, Lingling; Show all 8 Authors
- Source:
- Fish & shellfish immunology 2019 v.91 pp. 325-332
- ISSN:
- 1050-4648
- Subject:
- Crassostrea gigas; Crassostrea virginica; Octopodidae; amino acids; autophagy; cell viability; complementary DNA; double-stranded RNA; gene expression; gene expression regulation; gills; hemocytes; hepatopancreas; immune response; interferon regulatory factors; interferons; messenger RNA; open reading frames; oysters; polypeptides; shellfish
- Abstract:
- ... Autophagy, a highly conserved intracellular degradation system, is involved in numerous processes in vertebrate and invertebrate, such as cell survival, ageing, and immune responses. However, the detailed molecular mechanism of autophagy and its immune regulatory role in bivalves are still not well understood. In the present study, an autophagy-related protein ATG10 (designated as CgATG10) was ide ...
- DOI:
- 10.1016/j.fsi.2019.05.027
- https://dx.doi.org/10.1016/j.fsi.2019.05.027
- Author:
- Song, Linsheng, et al. ; Yu, Zichao; Liu, Chao; Wang, Feifei; Xue, Zhuang; Zhang, Anguo; Lu, Guangxia; Wang, Lingling; Show all 8 Authors
- Source:
- Aquaculture 2019 pp. 734266
- ISSN:
- 0044-8486
- Subject:
- Bacillariophyceae; Chlorophyta; Chrysophyceae; Dinophyceae; Mizuhopecten yessoensis; Noctilucales; algae; community structure; dissolved oxygen; energy; farming systems; grazing intensity; high-throughput nucleotide sequencing; mollusc culture; mortality; phytoplankton; ribosomal DNA; scallops; seawater; silicates; summer; temperature; China; Japan; Yellow Sea
- Abstract:
- ... Yesso scallop (Patinopecten yessoensis) is one of the most important maricultured scallops in northern China, which was first introduced from Japan in 1980s. However, with the rapid development of aquaculture, the frequent occurrence of Yesso scallop's high mortality in summer has led to huge production losses. In the present study, seawater samples were collected from Yesso scallop farming waters ...
- DOI:
- 10.1016/j.aquaculture.2019.734266
- https://dx.doi.org/10.1016/j.aquaculture.2019.734266
- Author:
- Song, Linsheng, et al. ; Song, Xiaorui; Song, Ying; Dong, Miren; Liu, Zhaoqun; Wang, Weilin; Wang, Lingling; Show all 7 Authors
- Source:
- Fish & shellfish immunology 2019 v.89 pp. 228-236
- ISSN:
- 1050-4648
- Subject:
- Crassostrea gigas; Vibrio splendidus; amino acids; cell nucleus; fluorescent antibody technique; gene expression regulation; gills; hematopoiesis; hemocytes; immune response; larvae; messenger RNA; oysters; polypeptides; shellfish; transcription factors
- Abstract:
- ... The Runx family is a kind of heteromeric transcription factors, which is defined by the presence of a runt domain. As transcriptional regulator during development and cell fate specification, Runx is best known for its critical roles in hematopoiesis. In the present study, a Runx transcription factor (designed as CgRunx) was identified and characterized from the oyster Crassostrea gigas. The compl ...
- DOI:
- 10.1016/j.fsi.2019.03.066
- https://dx.doi.org/10.1016/j.fsi.2019.03.066
- Author:
- Song, Linsheng, et al. ; Wang, Min; Liu, Chang; Wang, Weilin; Dong, Miren; Zhang, Peng; Liu, Yu; Wang, Lingling; Show all 8 Authors
- Source:
- Developmental and comparative immunology 2019 v.95 pp. 28-37
- ISSN:
- 0145-305X
- Subject:
- Crassostrea gigas; RNA interference; Vibrio splendidus; amino acids; cell growth; cytokines; cytoplasm; fluorescent antibody technique; gene expression; genes; granulocytes; hemocytes; lipopolysaccharides; messenger RNA; open reading frames; oysters; polypeptides; tissues
- Abstract:
- ... The sp1A/ryanodine receptor (SPRY) family members have been reported to involve in important biological pathways, including innate immune signaling, cytokine signaling suppression, development, cell growth, and retroviral restriction. In the present study, a SPRY domain-containing SOCS box protein (named as CgSPSB3) was identified and characterized from oyster Crassostrea gigas. The open reading f ...
- DOI:
- 10.1016/j.dci.2019.01.013
- https://dx.doi.org/10.1016/j.dci.2019.01.013
- Author:
- Song, Linsheng, et al. ; Wang, Weilin; Gong, Changhao; Han, Zirong; Lv, Xiaojing; Liu, Shujing; Wang, Lingling; Show all 7 Authors
- Source:
- Fish & shellfish immunology 2019 v.89 pp. 237-247
- ISSN:
- 1050-4648
- Subject:
- Crassostrea gigas; carbohydrate binding; complement; enzyme activity; enzymes; epidermal growth factor; lectins; males; mucosal immunity; oysters; receptors; recombinant fusion proteins; shellfish; surveys
- Abstract:
- ... Lectins are carbohydrate-binding proteins with lectin domains, which are extensively studied for their numerous roles in biological recognition. However, the lectin domain containing proteins (LDCPs) chimerized with other non-lectin domains have not received sufficient attention. In the present study, a genome-wide survey of LDCPs in oyster Crassostrea gigas was conducted, and an expansive 640 LDC ...
- DOI:
- 10.1016/j.fsi.2019.03.067
- https://dx.doi.org/10.1016/j.fsi.2019.03.067
- Author:
- Song, Linsheng, et al. ; Li, Meijia; Wang, Min; Wang, Weilin; Wang, Lingling; Liu, Zhaoqun; Sun, Jiejie; Wang, Kejian; Show all 8 Authors
- Source:
- Fish & shellfish immunology 2019 v.88 pp. 480-488
- ISSN:
- 1050-4648
- Subject:
- Crassostrea gigas; cytokines; ganglia; gene expression; gene expression regulation; genes; hemocytes; hepatopancreas; homeostasis; immune response; immunocytochemistry; immunohistochemistry; immunomodulators; lipopolysaccharides; messenger RNA; mitogen-activated protein kinase; muscles; neuropeptides; nitric oxide; oysters; pathogens; phosphorylation; phylogeny; shellfish
- Abstract:
- ... As one of the most important neuropeptides identified only in invertebrates of Mollusca, Annelida and Arthropoda, FMRFamide (Phe-Met-Arg-Phe-NH2) involves in multiple physiological processes, such as mediating cardiac frequency and contraction of somatic and visceral muscles. However, its modulatory role in the immune defense has not been well understood. In the present study, an FMRFamide precurs ...
- DOI:
- 10.1016/j.fsi.2019.03.023
- https://dx.doi.org/10.1016/j.fsi.2019.03.023
- Author:
- Song, Linsheng, et al. ; Zhang, Huan; Wang, Hao; Chen, Hao; Wang, Mengqiang; Zhou, Zhi; Qiu, Limei; Wang, Lingling; Show all 8 Authors
- Source:
- Developmental and comparative immunology 2019 v.94 pp. 1-10
- ISSN:
- 0145-305X
- Subject:
- Crassostrea gigas; Vibrio splendidus; aquaculture industry; bacterial infections; energy expenditure; energy metabolism; gene expression; heat stress; hemocytes; hepatopancreas; high-throughput nucleotide sequencing; immune response; immune system; immunomodulation; messenger RNA; mortality; oysters; pathogens; quantitative polymerase chain reaction; signal transduction; stress response; summer; transcription (genetics)
- Abstract:
- ... Bacterial infection and heat stress are considered as two major environmental threats for the aquaculture industry of oyster Crassostrea gigas. In the present study, the expression profiles of mRNA transcripts in the hemocytes of oysters under bacterial challenge and heat stress were examined by next-generation sequencing. There were 21,095, 21,957 and 21,141 transcripts identified in the hemocyte ...
- DOI:
- 10.1016/j.dci.2019.01.006
- https://dx.doi.org/10.1016/j.dci.2019.01.006
- Author:
- Song, Linsheng, et al. ; Liu, Rui; Cheng, Qi; Song, Xiaorui; Wang, Hao; Wang, Xiudan; Wang, Lingling; Zhu, Beiwei; Show all 8 Authors
- Source:
- Developmental and comparative immunology 2019 v.91 pp. 132-142
- ISSN:
- 0145-305X
- Subject:
- Crassostrea gigas; amino acids; apoptosis; cell communication; cell-mediated immunity; hemocytes; hepatopancreas; immune response; inflammation; innate immunity; lipopolysaccharides; males; messenger RNA; molecular weight; oysters; pathogens; phylogeny; polypeptides; transcription factor NF-kappa B; tumor necrosis factor-alpha; ubiquitin; ubiquitin-protein ligase; ubiquitination; vertebrates
- Abstract:
- ... As an important post-translational protein modification, ubiquitination has been demonstrated to play a vital role in immune response of vertebrates. Ubiquitin (Ub)-conjugating enzyme E2 is the “heart” of ubiquitination, which is responsible for Ub cellular signaling and substrate modification. In the present study, an Ub-conjugating enzyme E2 (designed as CgUbe2g1) was identified from oyster Cras ...
- DOI:
- 10.1016/j.dci.2018.10.014
- https://dx.doi.org/10.1016/j.dci.2018.10.014
- Author:
- Song, Linsheng, et al. ; Sun, Jiejie; Wang, Lingling; Wu, Zhaojun; Han, Shuo; Wang, Liyan; Li, Meijia; Liu, Zhaoqun; Show all 8 Authors
- Source:
- Developmental and comparative immunology 2019 v.91 pp. 108-114
- ISSN:
- 0145-305X
- Subject:
- Crassostrea gigas; Crassostrea hongkongensis; Vibrio splendidus; complementary DNA; hemocytes; immune response; innate immunity; interleukins; lipopolysaccharides; mitogen-activated protein kinase; open reading frames; oysters; phosphorylation; serine; threonine; tumor necrosis factors; vertebrates
- Abstract:
- ... P38 mitogen-activated protein kinases are serine/threonine protein kinases reportedly involved in the innate immunity of vertebrates and invertebrates. In the present study, a P38 homolog (CgP38) was characterized from the Pacific oyster Crassostrea gigas. The full-length cDNA of CgP38 was of 1515 bp containing a 1101 bp open reading frame. A serine/threonine protein kinase (S_TKc) domain with a c ...
- DOI:
- 10.1016/j.dci.2018.10.011
- https://dx.doi.org/10.1016/j.dci.2018.10.011
- Author:
- Song, Linsheng, et al. ; Lv, Zhao; Qiu, Limei; Jia, Zhihao; Wang, Weilin; Liu, Zhaoqun; Wang, Lingling; Show all 7 Authors
- Source:
- Fish & shellfish immunology 2019
- ISSN:
- 1050-4648
- Subject:
- Crassostrea gigas; Escherichia coli; Insecta; antibodies; bacteria; blood serum; calcium; cyclic AMP; fish; fluorescein; fluorescence; gene expression regulation; guanosinetriphosphatase; hemocytes; hepatopancreas; integrins; isothiocyanates; lipopolysaccharides; messenger RNA; muscles; oysters; peptides; phagocytosis; phylogeny; receptors; shellfish; talin; tissues
- Abstract:
- ... Integrins are an important family of cell receptors that can bind foreign particles and promote cell phagocytosis after they are activated. In the present study, a novel β integrin was identified from pacific oyster Crassostrea gigas with an extracellular domain, a single transmembrane segment, and a short cytoplasmic domain. It was phylogenetically clustered with phagocytosis-related insecta βV, ...
- DOI:
- 10.1016/j.fsi.2019.01.047
- https://dx.doi.org/10.1016/j.fsi.2019.01.047
- Author:
- Song, Linsheng, et al. ; Zong, Yanan; Liu, Zhaoqun; Wu, Zhaojun; Han, Zirong; Wang, Lingling; Show all 6 Authors
- Source:
- Fish & shellfish immunology 2019 v.84 pp. 920-926
- ISSN:
- 1050-4648
- Subject:
- Aeromonas hydrophila; Crassostrea gigas; Crassostrea virginica; Escherichia coli; Gram-negative bacteria; Gram-positive bacteria; Komagataella pastoris; Micrococcus luteus; Mizuhopecten yessoensis; Mytilus galloprovincialis; Staphylococcus aureus; Vibrio alginolyticus; Vibrio anguillarum; Vibrio splendidus; Yarrowia lipolytica; amino acids; binding capacity; fish; fungi; gills; hemocytes; hepatopancreas; immunology; ligands; lipopolysaccharides; messenger RNA; muscles; open reading frames; palps; pathogen-associated molecular patterns; peptidoglycans; phylogeny; polypeptides; receptors; recombinant proteins; shellfish; tissues
- Abstract:
- ... The globular C1q domain containing (C1qDC) proteins are a family of versatile pattern recognition receptors (PRRs) to bind various ligands by their globular C1q (gC1q) domain. In the present study, a novel globular C1qDC (CgC1qDC-7) was characterized from Pacific oyster Crassostrea gigas. The open reading frame of CgC1qDC-7 was of 555 bp, encoding a polypeptide of 185 amino acids. Phylogenetic ana ...
- DOI:
- 10.1016/j.fsi.2018.10.079
- https://dx.doi.org/10.1016/j.fsi.2018.10.079
- Author:
- Song, Linsheng, et al. ; Wang, Mengqiang; Wang, Lingling; Jia, Zhihao; Yi, Qilin; Show all 5 Authors
- Source:
- Fish & shellfish immunology 2018 v.74 pp. 205-212
- ISSN:
- 1050-4648
- Subject:
- Azumapecten farreri; Toll-like receptors; expressed sequence tags; fish; gene expression; hepatopancreas; innate immunity; scallops; screening; shellfish; signal transduction; tissues; transcriptomics
- Abstract:
- ... Toll-like receptor (TLR) signaling pathway, composed of various components, plays pivotal roles in host innate immune defense mechanism. In the present study, twenty-nine TLR signaling pathway components, including receptors, adaptors, transduction molecules and immune effectors, were identified in Zhikong scallop Chlamys farreri via assembling and screening public available transcriptomic data an ...
- DOI:
- 10.1016/j.fsi.2017.12.064
- https://dx.doi.org/10.1016/j.fsi.2017.12.064
- Author:
- Song, Linsheng, et al. ; Wu, Zhaojun; Sun, Jiejie; Wang, Liyan; Zong, Yanan; Han, Zirong; Yang, Wen; Liu, Zhaoqun; Wang, Lingling; Show all 9 Authors
- Source:
- Fish & shellfish immunology 2019 v.93 pp. 1084-1092
- ISSN:
- 1050-4648
- Subject:
- Crassostrea gigas; Eriocheir sinensis; amino acid sequences; amino acids; complementary DNA; gene expression; gene expression regulation; hemocytes; immune response; interleukins; lipopolysaccharides; messenger RNA; open reading frames; oysters; phylogeny; shellfish; signal transduction
- Abstract:
- ... As a family of negatively feedback regulating factors, the suppressor of cytokine signaling (SOCS) can depress cytokine signal transduction, and eventually modulate growth, development, differentiation, and immune response. In the present study, a SOCS homologue (designated as CgSOCS6) was identified from oyster Crassostrea gigas. The open reading frame of CgSOCS6 cDNA was of 1167 bp encoding a pe ...
- DOI:
- 10.1016/j.fsi.2019.08.055
- https://dx.doi.org/10.1016/j.fsi.2019.08.055
- Author:
- Song, Linsheng, et al. ; Li, Huan; Kong, Ning; Sun, Jiejie; Wang, Weilin; Li, Meijia; Gong, Changhao; Dong, Miren; Wang, Min; Wang, Lingling; Show all 10 Authors
- Source:
- Developmental and comparative immunology 2019 v.98 pp. 157-165
- ISSN:
- 0145-305X
- Subject:
- Crassostrea gigas; Escherichia coli; Gram-negative bacteria; Gram-positive bacteria; Komagataella pastoris; Micrococcus luteus; Staphylococcus aureus; Vibrio splendidus; amino acids; chemotaxis; collagen; dose response; fungi; hemocytes; hepatopancreas; immune response; mannose; messenger RNA; muscles; oligomerization; oysters; pathogen-associated molecular patterns; pathogens; peptides; phagocytosis; phylogeny; polyinosinic-polycytidylic acid; protein content; signal peptide; tissues; vertebrates
- Abstract:
- ... Most of the bivalve C1q domain containing proteins (C1qDCs) are either only composed of the globular head domain, or contain an N-terminal coiled-coil domain, presumed to cover a role in oligomerization. On the other hand, collagen regions, widespread in vertebrate C1qDCs, are very uncommon in bivalves. In the present study, a C1qDC with a collagen-like domain (designated CgC1qDC-6) was identified ...
- DOI:
- 10.1016/j.dci.2019.04.010
- https://dx.doi.org/10.1016/j.dci.2019.04.010
- Author:
- Song, Linsheng, et al. ; Song, Xiaorui; Xin, Xiaoyu; Wang, Hao; Li, Hui; Zhang, Huan; Jia, Zhihao; Liu, Conghui; Jiang, Shuai; Wang, Lingling; Show all 10 Authors
- Source:
- Fish & shellfish immunology 2019 v.92 pp. 772-781
- ISSN:
- 1050-4648
- Subject:
- Crassostrea gigas; Escherichia coli; Komagataella pastoris; Micrococcus luteus; Staphylococcus aureus; Vibrio anguillarum; Vibrio splendidus; Yarrowia lipolytica; amino acid sequences; amino acids; antibacterial properties; bacteria; binding capacity; hemocytes; hepatopancreas; immune response; immunohistochemistry; lectins; lipopolysaccharides; mannose; muscles; oysters; pathogen-associated molecular patterns; pathogens; peptidoglycans; phagocytosis; receptors; recombinant proteins; shellfish
- Abstract:
- ... C-type lectins (CTLs), as important pattern recognition receptors (PRRs), are a superfamily of Ca2+-dependent carbohydrate-recognition proteins which participate in nonself-recognition and eliminating pathogens. In the present study, a novel CTL (designated as CgCLec-3) was identified from the Pacific oyster Crassostrea gigas. There was only one carbohydrate-recognition domain (CRD) of 151 amino a ...
- DOI:
- 10.1016/j.fsi.2019.07.001
- https://dx.doi.org/10.1016/j.fsi.2019.07.001
- Author:
- Song, Linsheng, et al. ; Lv, Zhao; Wang, Lingling; Jia, Zhihao; Sun, Jiejie; Wang, Weilin; Liu, Zhaoqun; Qiu, Limei; Wang, Mengqiang; Show all 9 Authors
- Source:
- Developmental and comparative immunology 2019 v.98 pp. 42-53
- ISSN:
- 0145-305X
- Subject:
- Crassostrea gigas; Escherichia coli; Gram-negative bacteria; Vibrio anguillarum; Vibrio parahaemolyticus; Vibrio splendidus; cell membranes; hemocytes; lipid A; opsonins; oysters; pathogen-associated molecular patterns; phagocytosis; receptors; surface plasmon resonance
- Abstract:
- ... Phagocytosis constitutes a conserved cellular process for multicellular animals to ingest or engulf other cells or particles, which is facilitated by the use of opsonins to bind foreign particles and interact with cell surface receptors. The invertebrate secreted C1q domain-containing proteins (C1qDCs) have been reported to exhibit opsonic activity, while the detailed mechanisms of opsonization st ...
- DOI:
- 10.1016/j.dci.2019.04.004
- https://dx.doi.org/10.1016/j.dci.2019.04.004
- Author:
- Song, Linsheng, et al. ; Dong, Miren; Song, Xiaorui; Wang, Min; Wang, Weilin; Zhang, Peng; Liu, Yu; Li, Meijia; Wang, Lingling; Show all 9 Authors
- Source:
- Fish & shellfish immunology 2019 v.87 pp. 96-104
- ISSN:
- 1050-4648
- Subject:
- Crassostrea gigas; Vibrio splendidus; alcohols; amino acids; density gradient centrifugation; fish; flow cytometry; ganglia; gene expression; gene expression regulation; granulocytes; hemocytes; hepatopancreas; immune response; in vitro culture; messenger RNA; monoclonal antibodies; muscles; open reading frames; oysters; peptides; pseudopodia; shellfish; transferases
- Abstract:
- ... Granulocytes are known as the main immunocompetent hemocytes that play important roles in the immune defense of oyster Crassostrea gigas. In the present study, an alcohol acyltransferase (designed as CgAATase) with specific expression pattern was identified from oyster C. gigas, and it could be employed as a potential marker for the isolation of oyster granulocytes. The open reading frame (ORF) of ...
- DOI:
- 10.1016/j.fsi.2019.01.003
- https://dx.doi.org/10.1016/j.fsi.2019.01.003
- Author:
- Song, Linsheng, et al. ; Wang, Lingling; Zhang, Huan; Wang, Mengqiang; Zhou, Zhi; Wang, Weilin; Liu, Rui; Huang, Mengmeng; Yang, Chuanyan; Qiu, Limei; Show all 10 Authors
- Source:
- Developmental and comparative immunology 2019 v.91 pp. 1-7
- ISSN:
- 0145-305X
- Subject:
- Crassostrea gigas; gene expression regulation; genes; genomics; glucans; hemocytes; immune response; innate immunity; lectins; lipopolysaccharides; microorganisms; oysters; pathogen-associated molecular patterns; pathogens; peptidoglycans; polyinosinic-polycytidylic acid; receptors; sequence analysis; surveys; transcriptomics
- Abstract:
- ... Pattern recognition receptors (PRRs) are essential in recognizing specific pathogen-associated molecular patterns (PAMPs) on microbes and triggering responses to eliminate the invading pathogens. Previous genomic studies have revealed a great number of PRR genes in the Pacific oyster Crassostrea gigas, a sessile and filter-feeder marine bivalve belonging to the phylum Mollusca. On the survey of PR ...
- DOI:
- 10.1016/j.dci.2018.09.021
- https://dx.doi.org/10.1016/j.dci.2018.09.021
- Author:
- Song, Linsheng, et al. ; Lv, Zhao; Song, Xiaorui; Xu, Jiachao; Jia, Zhihao; Yang, Bin; Jia, Yunke; Qiu, Limei; Wang, Lingling; Show all 9 Authors
- Source:
- Fish & shellfish immunology 2019 v.84 pp. 587-598
- ISSN:
- 1050-4648
- Subject:
- Crassostrea gigas; RNA interference; Western blotting; amino acids; apoptosis; caspase-3; defense mechanisms; fish; gene expression; hemocytes; immune response; lipopolysaccharides; membrane potential; mitochondria; mitochondrial membrane; necrosis; nucleotides; open reading frames; oysters; polypeptides; protein content; proteins; shellfish
- Abstract:
- ... The mitochondrial pathway of apoptosis is well studied as the major mechanism of physiological cell death in vertebrates. In the present study, a second mitochondria-derived activator of caspases (Smac)/direct inhibitor of apoptosis-binding protein (IAP) with low pI protein (DIABLO) (designated as CgSmac) was identified from oyster Crassostrea gigas. The open reading frame of CgSmac was of 966 bp ...
- DOI:
- 10.1016/j.fsi.2018.10.035
- https://dx.doi.org/10.1016/j.fsi.2018.10.035