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1. Efficacy of A/H1N1/2009 split inactivated influenza A vaccine (GC1115) in mice and ferrets

Author:
Song, Min-Suk,   et al.   ; Han, Hae Jung; Park, Su-Jin; Byun, Han Yeul; Robles, Norbert John C.; Ha, Suk-Hoon; Choi, Young Ki;     Show all 7 Authors
Source:
The journal of microbiology 2019 v.57 no.2 pp. 163-169
ISSN:
1225-8873
Subject:
antibodies; antigens; body temperature; body weight changes; dose response; ferrets; hemagglutinins; immunization; immunogenicity; influenza; intramuscular injection; mice; models; nasal cavity; seroconversion; signs and symptoms (animals and humans); vaccines; viral load; viruses
Abstract:
... To evaluate the efficacy of a non-adjuvant A/H1N1/2009 influenza A vaccine (GC1115), we demonstrated the immunogenicity and protective efficacy of GC1115 in mouse and ferret models. The immunogenicity of GC1115 was confirmed after intramuscular administration of 1.875, 3.75, 7.5, and 15 μg hemagglutinin antigen (HA) in mice and 7.5, 15, and 30 μg HA in ferrets at 3-week intervals. A single immuniz ...
DOI:
10.1007/s12275-019-8504-1

2. Preclinical evaluation of the efficacy of an H5N8 vaccine candidate (IDCDC-RG43A) in mouse and ferret models for pandemic preparedness

Author:
Song, Min-Suk,   et al.   ; Jeong, Ju Hwan; Kim, Eun-Ha; Lloren, Khristine Kaith S.; Kwon, Jin Jung; Kwon, Hyeok-il; Ahn, Su Jeong; Kim, Young-Il; Choi, Won-Suk; Si, Young-Jae; Lee, Ok-Jun; Han, Hae Jung; Baek, Yun Hee; Choi, Young Ki; Kim, Chul-Joong;     Show all 15 Authors
Source:
Vaccine 2019 v.37 no.3 pp. 484-493
ISSN:
0264-410X
Subject:
Influenza A virus; adjuvants; aluminum hydroxide; animal tissues; antibodies; antigens; blood serum; brain; clinical trials; cross reaction; ferrets; genes; hemagglutinins; human diseases; immunogenicity; kidneys; lungs; mice; models; neutralization tests; pandemic; spleen; vaccines; virus replication; viruses
Abstract:
... Because H5N1 influenza viruses continuously threaten the public health, the WHO has prepared various clades of H5N1 mock-up vaccines as one of the measures for pandemic preparedness. The recent worldwide outbreak of H5Nx virus which belongs to clade 2.3.4.4 and of which H5N6 subtype belongs and already caused human infection also increases the need of pandemic vaccine for such novel emerging virus ...
DOI:
10.1016/j.vaccine.2018.11.064

3. Virological and pathological characterization of an avian H1N1 influenza A virus

Author:
Song, Min-Suk,   et al.   ; Koo, Bon-Sang; Kim, HyeKwon; Song, Daesub; Na, Woonsung; Kwon, JinJung; Wong, Sook-San; Noh, JiYeong; Ahn, Min-Ju; Kim, Doo-Jin; Webby, RichardJ; Yoon, Sun-Woo; Jeong, DaeGwin;     Show all 13 Authors
Source:
Archives of virology 2018 v.163 no.5 pp. 1153-1162
ISSN:
0304-8608
Subject:
Influenza A virus; animal models; direct contact; epithelial cells; genes; guinea pigs; humans; mice; migratory birds; monitoring; nose; nucleotide sequences; pandemic; pathogenicity; phylogeny; risk assessment; viruses; wild birds; winter; South Korea
Abstract:
... Gene segments from avian H1N1 influenza A viruses have reassorted with other influenza viruses to generate pandemic strains over the past century. Nevertheless, little effort has been invested in understanding the characteristics of avian H1N1 influenza viruses. Here, we present the genome sequence and a molecular and virological characterization of an avian influenza A virus, A/wild bird/Korea/SK ...
DOI:
10.1007/s00705-018-3730-0

4. Genetic and phylogenetic characterizations of a novel genotype of highly pathogenic avian influenza (HPAI) H5N8 viruses in 2016/2017 in South Korea

Author:
Song, Min-Suk,   et al.   ; Kim, Young-Il; Park, Su-Jin; Kwon, Hyeok-Il; Kim, Eun-Ha; Si, Young-Jae; Jeong, Ju-Hwan; Lee, In-Won; Nguyen, Hiep Dinh; Kwon, Jin-Jung; Choi, Won Suk; Kim, Chul-Joong; Choi, Young-Ki;     Show all 13 Authors
Source:
Infection, genetics, and evolution 2017 v.53 pp. 56-67
ISSN:
1567-1348
Subject:
avian influenza; chickens; genes; genotype; migratory birds; phylogeny; viruses; South Korea
Abstract:
... During the outbreaks of highly pathogenic avian influenza (HPAI) H5N6 viruses in 2016 in South Korea, novel H5N8 viruses were also isolated from migratory birds. Phylogenetic analysis revealed that the HA gene of these H5N8 viruses belonged to clade 2.3.4.4, similarly to recent H5Nx viruses, and originated from A/Brk/Korea/Gochang1/14(H5N8), a minor lineage of H5N8 that appeared in 2014 and then d ...
DOI:
10.1016/j.meegid.2017.05.001

5. Genetic diversity and pathogenic potential of low pathogenic H7 avian influenza viruses isolated from wild migratory birds in Korea

Author:
Song, Min-Suk,   et al.   ; Kim, Young-Il; Kim, Si-Wook; Si, Young-Jae; Kwon, Hyeok-Il; Park, Su-Jin; Kim, Eun-Ha; Kim, Se mi; Lee, In-Won; Choi, Young-Ki;     Show all 10 Authors
Source:
Infection, genetics, and evolution 2016 v.45 pp. 268-284
ISSN:
1567-1348
Subject:
Influenza A virus; chickens; cross reaction; genes; genetic variation; genotype; lungs; markets; mice; migratory birds; monitoring; mortality; pandemic; pathogenicity; phylogeny; viruses; China; South Korea
Abstract:
... To detect the circulation of H7 avian influenza viruses, we characterized H7 viruses found in migratory birds and live poultry markets of South Korea from 2005 to 2014. Phylogenic analysis revealed that while all viruses clustered into the Eurasian-lineage of H7 avian viruses, at least 12 distinct genotypes were represented. Most H7 viruses contained at least one gene segment from the highly-patho ...
DOI:
10.1016/j.meegid.2016.09.005

6. Genetic characteristics of highly pathogenic H5N8 avian influenza viruses isolated from migratory wild birds in South Korea during 2014-2015

Author:
Song, Min-Suk,   et al.   ; Si, Young-Jae; Choi, Won Suk; Kim, Young-Il; Lee, In-Won; Kwon, Hyeok-Il; Park, Su-Jin; Kim, Eun-Ha; Kim, Se mi; Kwon, Jin-Jung; Kim, Chul-Joong; Choi, Young-Ki;     Show all 12 Authors
Source:
Archives of virology 2016 v.161 no.10 pp. 2749-2764
ISSN:
0304-8608
Subject:
Influenza A virus; avian influenza; genes; hemagglutination; migratory behavior; migratory birds; phylogeny; virulence; viruses; wild birds; winter; Europe; North America; South Korea
Abstract:
... The continuous worldwide spread of highly pathogenic avian influenza (HPAI) H5N8 viruses among wild birds and poultry is a potential threat to public health. In the present study, we investigated the genetic characteristics of recent H5N8 viruses continuously isolated from migratory birds over two winters (2013-2014 and 2014-2015) in South Korea. Genetic and phylogenetic analysis demonstrated that ...
DOI:
10.1007/s00705-016-2979-4

7. Molecular characterization of mammalian-adapted Korean-type avian H9N2 virus and evaluation of its virulence in mice

Author:
Song, Min-Suk,   et al.   ; Park, Kuk Jin; Kim, Eun-Ha; Kwon, Hyeok-il; Baek, Yun Hee; Choi, Eun-hye; Park, Su-Jin; Kim, Se Mi; Kim, Young-il; Choi, Won-Suk; Yoo, Dae-Won; Kim, Chul-Joong; Choi, Young Ki;     Show all 13 Authors
Source:
The journal of microbiology 2015 v.53 no.8 pp. 570-577
ISSN:
1225-8873
Subject:
Influenza A virus; amino acids; birds; data analysis; disease transmission; evolution; genes; genetic markers; humans; mice; microbiology; migratory behavior; mortality; mutation; pandemic; poultry; poultry diseases; virulence; Korean Peninsula
Abstract:
... Avian influenza A virus (AIV) is commonly isolated from domestic poultry and wild migratory birds, and the H9N2 subtype is the most prevalent and the major cause of severe disease in poultry in Korea. In addition to the veterinary concerns regarding the H9N2 subtype, it is also considered to be the next potential human pandemic strain due to its rapid evolution and interspecies transmission. In th ...
DOI:
10.1007/s12275-015-5329-4

8. Development of a dual-protective live attenuated vaccine against H5N1 and H9N2 avian influenza viruses by modifying the NS1 gene

Author:
Song, Min-Suk,   et al.   ; Choi, Eun-hye; Park, Su-Jin; Pascua, Philippe Noriel Q.; Baek, Yun Hee; Kwon, Hyeok-il; Kim, Eun-Ha; Kim, Semi; Jang, Hyung-Kwan; Poo, Haryoung; Kim, Chul-Joong; Choi, Young Ki;     Show all 12 Authors
Source:
Archives of virology 2015 v.160 no.7 pp. 1729-1740
ISSN:
0304-8608
Subject:
Orthomyxoviridae; animal models; avian influenza; chickens; financial economics; genes; hosts; human health; humans; interferon-beta; live vaccines; mice; mutation; risk; vaccination; viral nonstructural proteins; virulence; viruses
Abstract:
... An increasing number of outbreaks of avian influenza H5N1 and H9N2 viruses in poultry have caused serious economic losses and raised concerns for human health due to the risk of zoonotic transmission. However, licensed H5N1 and H9N2 vaccines for animals and humans have not been developed. Thus, to develop a dual H5N1 and H9N2 live-attenuated influenza vaccine (LAIV), the HA and NA genes from a vir ...
DOI:
10.1007/s00705-015-2442-y

9. Evaluation of the zoonotic potential of a novel reassortant H1N2 swine influenza virus with gene constellation derived from multiple viral sources

Author:
Song, Min-Suk,   et al.   ; Lee, Jee Hoon; Pascua, Philippe Noriel Q.; Decano, Arun G.; Kim, Se Mi; Park, Su-Jin; Kwon, Hyeok-Il; Kim, Eun-Ha; Kim, Young-Il; Kim, HyongKyu; Kim, Seok-Yong; Jang, Hyung-Kwan; Park, Bong Kyun; Choi, Young Ki;     Show all 14 Authors
Source:
Infection, genetics, and evolution 2015 v.34 pp. 378-393
ISSN:
1567-1348
Subject:
Influenza A virus; epithelial cells; ferrets; genes; hemagglutinins; humans; in vitro studies; influenza; lungs; mice; monitoring; nose; pandemic; phylogeny; sialidase; swine; viral load; viruses; zoonoses; South Korea
Abstract:
... In 2011–2012, contemporary North American-like H3N2 swine influenza viruses (SIVs) possessing the 2009 pandemic H1N1 matrix gene (H3N2pM-like virus) were detected in domestic pigs of South Korea where H1N2 SIV strains are endemic. More recently, we isolated novel reassortant H1N2 SIVs bearing the Eurasian avian-like swine H1-like hemagglutinin and Korean swine H1N2-like neuraminidase in the intern ...
DOI:
10.1016/j.meegid.2015.06.005

10. Role of the p21-activated kinases (PAKs) in influenza A virus replication

Author:
Song, Min-Suk,   et al.   ; Pascua, Philippe Noriel Q.; Lee, Jun-Han; Park, Soo-Jin; Baek, Yun Hee; Ann, Byung-Hoon; Shin, Eun-Young; Kim, Eung-Gook; Choi, Young-Ki;     Show all 9 Authors
Source:
Biochemical and biophysical research communications 2011 v.414 no.3 pp. 569-574
ISSN:
0006-291X
Subject:
Orthomyxoviridae; mitogen-activated protein kinase; phosphorylation; serine; small interfering RNA; threonine; transfection; vector control; viral load; virus replication; viruses
Abstract:
... Influenza A virus infection stimulates a wide range of virus-supportive or antiviral mechanisms in host cells. p21-Activated kinase 1 (PAK1) is a serine/threonine kinase that regulates a number of fundamental cellular processes and has been implicated in the modulation of virus replication. Here, we investigated the role of PAK1 activation during influenza A virus infection and found that virus pr ...
DOI:
10.1016/j.bbrc.2011.09.119

11. Complete protection against a H5N2 avian influenza virus by a DNA vaccine expressing a fusion protein of H1N1 HA and M2e

Author:
Song, Min Suk,   et al.   ; Park, Ki Seok; Seo, Yong Bok; Lee, Ji Yeung; Im, Se Jin; Seo, Sang Hwan; Choi, Young Ki; Sung, Young Chul;     Show all 8 Authors
Source:
Vaccine 2011 v.29 no.33 pp. 5481-5487
ISSN:
0264-410X
Subject:
DNA; DNA viruses; Influenza A virus; T-lymphocytes; antigens; conserved sequences; hemagglutinins; immune response; influenza; mortality; neutralizing antibodies; pandemic; recombinant vaccines; vaccination; viruses
Abstract:
... Most influenza vaccines target hemagglutinin (HA) in order to protect the host against infection. However, theses vaccines are strain-specific due to major antigenic variations of HA. Since it is difficult to predict epidemic and pandemic strains of influenza virus, the development of effective vaccines against divergent influenza viruses is urgently needed. Although M2e-based vaccines are associa ...
DOI:
10.1016/j.vaccine.2011.05.062

12. Prokaryote-expressed M2e protein improves H9N2 influenza vaccine efficacy and protection against lethal influenza a virus in mice

Author:
Song, Min-Suk,   et al.   ; Kim, Eun-Ha; Lee, Jun-Han; Pascua, Philippe Noriel Q; Baek, Yun-Hee; Kwon, Hyeok-il; Park, Su-Jin; Lim, Gyo-Jin; Decano, Arun; Chowdhury, Mohammed YE; Seo, Su-Kyung; Song, Man Ki; Kim, Chul-Joong; Choi, Young-Ki;     Show all 14 Authors
Source:
Virology journal 2013 v.10 no.1 pp. 2100
ISSN:
1743-422X
Subject:
Escherichia coli; Influenza A virus; chickens; consensus sequence; cross reaction; death; humoral immunity; influenza; lethal dose; mice; monitoring; pandemic; protein synthesis; vaccination; vaccine development; vaccines; viruses; water birds
Abstract:
... BACKGROUND: Influenza vaccines are prepared annually based on global epidemiological surveillance data. However, since there is no method by which to predict the influenza strain that will cause the next pandemic, the demand to develop new vaccination strategies with broad cross-reactivity against influenza viruses are clearly important. The ectodomain of the influenza M2 protein (M2e) is an attra ...
DOI:
10.1186/1743-422X-10-104
PubMed:
23551908
PubMed Central:
PMC3621599

13. Adjuvant efficacy of mOMV against avian influenza virus infection in mice

Author:
Song, Min-Suk,   et al.   ; Lee, Byeong-Jae; Lee, Sang-Ho; Pascua, Philippe Noriel Q.; Kwon, Hyeok-il; Park, Su-Jin; Kim, Eun-Ha; Decano, Arun; Kim, Se Mi; Lim, Gyo Jin; Kim, Doo-Jin; Chang, Kyu-Tae; Kim, Sang-Hyun; Choi, Young Ki;     Show all 14 Authors
Source:
The journal of microbiology 2013 v.51 no.5 pp. 682-688
ISSN:
1225-8873
Subject:
Influenza A virus; aluminum hydroxide; antibodies; avian influenza; body weight changes; death; genetics; humans; immunity; mice; microbiology; survival rate; vaccination; vaccine adjuvants; vaccines; viral antigens; virus transmission
Abstract:
... Highly pathogenic avian influenza H5N1 viruses are found chiefly in birds and have caused severe disease and death in infected humans. Development of influenza vaccines capable of inducing heterosubtypic immunity against a broad range of influenza viruses is the best option for the preparedness, since vaccination remains the principal method in controlling influenza viral infections. Here, a mOMV- ...
DOI:
10.1007/s12275-013-3411-3

14. Sublingual administration of bacteria-expressed influenza virus hemagglutinin 1 (HA1) induces protection against infection with 2009 pandemic H1N1 influenza virus

Author:
Song, Min-Suk,   et al.   ; Shim, Byoung-Shik; Choi, Jung-ah; Song, Ho-Hyun; Park, Sung-Moo; Cheon, In Su; Jang, Ji-Eun; Woo, Sun Je; Cho, Chung Hwan; Kim, Hyemi; Song, Kyung Joo; Lee, Jae Myun; Kim, Suhng Wook; Song, Dae Sub; Choi, Young Ki; Kim, Jae-Ouk; Nguyen, Huan Huu; Kim, Dong Wook; Bahk, Young Yil; Yun, Cheol-Heui; Song, Man Ki;     Show all 21 Authors
Source:
The journal of microbiology 2013 v.51 no.1 pp. 130-135
ISSN:
1225-8873
Subject:
Influenza A virus; antibodies; cholera toxin; hemagglutinins; humans; influenza; intramuscular injection; mice; morbidity; mortality; mucosal immunity; neutralization; oral administration; pandemic; pathogens; recombinant proteins; risk; vaccination; vaccines
Abstract:
... Influenza viruses are respiratory pathogens that continue to pose a significantly high risk of morbidity and mortality of humans worldwide. Vaccination is one of the most effective strategies for minimizing damages by influenza outbreaks. In addition, rapid development and production of efficient vaccine with convenient administration is required in case of influenza pandemic. In this study, we ge ...
DOI:
10.1007/s12275-013-2399-z
PubMed:
23456722

15. Genetic characterization and pathogenicity assessment of highly pathogenic H5N1 avian influenza viruses isolated from migratory wild birds in 2011, South Korea

Author:
Song, Min-Suk,   et al.   ; Kwon, Hyeok-il; Pascua, Philippe Noriel Q.; Baek, Yun Hee; Lee, Jun Han; Hong, Seung-Pyo; Rho, Jong-Bok; Kim, Jeong-Ki; Poo, Haryoung; Kim, Chul-Joong; Choi, Young Ki;     Show all 11 Authors
Source:
Virus research 2011 v.160 no.1-2 pp. 305-315
ISSN:
0168-1702
Subject:
Influenza A virus; avian influenza; chickens; ducks; feces; ferrets; genes; hosts; humans; mice; migratory behavior; models; monitoring; pandemic; public health; respiratory system; sequence homology; virulence; viruses; wild birds; South Korea
Abstract:
... The continued spread of a highly pathogenic avian influenza (HPAI) H5N1 virus among wild birds and poultry has posed a potential threat to human public health. In the present study, we report the isolation of HPAI H5N1 viruses (A/Md/Korea/W401/11 and A/Md/Korea/W404/11) from fecal samples of migratory birds. Genetic and phlyogenetic analyses demonstrated that these viruses are genetically identica ...
DOI:
10.1016/j.virusres.2011.07.003

16. Active reassortment of H9 influenza viruses between wild birds and live-poultry markets in Korea

Author:
Song, Min Suk,   et al.   ; Moon, Ho Jin; Cruz, Deu John M.; Park, Kuk Jin; Pascua, Philippe Noriel Q.; Lee, Jun Han; Baek, Yun Hee; Choi, Dong Ho; Choi, Young Ki; Kim, Chul Joong;     Show all 10 Authors
Source:
Archives of virology 2010 v.155 no.2 pp. 229-241
ISSN:
0304-8608
Subject:
Orthomyxoviridae; avian influenza; genes; genotype; markets; monitoring; phylogeny; poultry; viruses; wild birds; Korean Peninsula
Abstract:
... Surveillance of H9 avian influenza viruses in Korean live-poultry markets from September 2004 through October 2007 was carried out to investigate active reassortment between wild migratory birds and domestic poultry in Korea. Antigenic and phylogenetic analyses showed that most of the isolates belong to the previous Korean H9N2-like lineage and differ from the southeastern Chinese strains. Interes ...
DOI:
10.1007/s00705-009-0577-4
PubMed:
20033463

17. Virulence and transmissibility of H1N2 influenza virus in ferrets imply the continuing threat of triple-reassortant swine viruses

Author:
Song, Min-Suk,   et al.   ; Pascua, Philippe Noriel Q.; Lee, Jun Han; Baek, Yun Hee; Kwon, Hyeok-il; Park, Su-Jin; Choi, Eun Hye; Lim, Gyo-Jin; Lee, Ok-Jun; Kim, Si-Wook; Kim, Chul-Joong; Sung, Moon Hee; Kim, Myung Hee; Yoon, Sun-Woo; Govorkova, Elena A.; Webby, Richard J.; Webster, Robert G.; Choi, Young-Ki;     Show all 18 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.39 pp. 15900-15905
ISSN:
0027-8424
Subject:
Influenza A virus; death; droplets; ferrets; hemagglutinins; humans; influenza; lungs; mice; models; monitoring; mutation; pandemic; sialidase; swine; vertebrate viruses; virulence; viruses
Abstract:
... Efficient worldwide swine surveillance for influenza A viruses is urgently needed; the emergence of a novel reassortant pandemic H1N1 (pH1N1) virus in 2009 demonstrated that swine can be the direct source of pandemic influenza and that the pandemic potential of viruses prevalent in swine populations must be monitored. We used the ferret model to assess the pathogenicity and transmissibility of pre ...
DOI:
10.1073/pnas.1205576109
PubMed:
23019374
PubMed Central:
PMC3465388

18. Evaluation of the efficacy of a pre-pandemic H5N1 vaccine (MG1109) in mouse and ferret models

Author:
Song, Min-Suk,   et al.   ; Moon, Ho-Jin; Kwon, Hyeok-il; Pascua, Philippe Noriel Q.; Lee, Jun Han; Baek, Yun Hee; Woo, Kyu-Jin; Choi, Juhee; Lee, Sangho; Yoo, Hyunseung; Oh, Ingyeong; Yoon, Yeup; Rho, Jong-Bok; Sung, Moon-Hee; Hong, Seung-Pyo; Kim, Chul-Joong; Choi, Young Ki;     Show all 17 Authors
Source:
The journal of microbiology 2012 v.50 no.3 pp. 478-488
ISSN:
1225-8873
Subject:
Influenza A virus; animal models; avian influenza; cross reaction; ferrets; genes; inactivated vaccines; lungs; mice; microbial growth; viruses; water birds
Abstract:
... The threat of a highly pathogenic avian influenza (HPAI) H5N1 virus causing the next pandemic remains a major concern. In this study, we evaluated the immunogenicity and efficacy of an inactivated whole-virus H5N1 pre-pandemic vaccine (MG1109) formulated by Green Cross Co., Ltd containing the hemagglutinin (HA) and neuraminidase (NA) genes of the clade 1 A/Vietnam/1194/04 virus in the backbone of ...
DOI:
10.1007/s12275-012-1573-z
PubMed:
22752912

19. Prevalence and genetic characterization of respiratory syncytial virus (RSV) in hospitalized children in Korea

Author:
Song, Min-Suk,   et al.   ; Baek, Yun Hee; Choi, Eun Hye; Pascua, Philippe Noriel Q.; Kwon, Hyeok-il; Park, Su-Jin; Lee, Jun Han; Woo, Sung-Il; Ahn, Byung-Hoon; Han, Heon-Seok; Hahn, Yoon-Soo; Shin, Kyeong-Seob; Jang, Hae-Lan; Kim, Seok-Yong; Choi, Young-Ki;     Show all 15 Authors
Source:
Archives of virology 2012 v.157 no.6 pp. 1039-1050
ISSN:
0304-8608
Subject:
hospitals; phylogeny; Human orthopneumovirus; amino acid sequences; universities; children; viruses; genes; genotype; molecular epidemiology; patients; genetic variation; pathogens; infants; South Korea
Abstract:
... Human respiratory syncytial virus (HRSV) is the most common respiratory pathogen among infants and young children. To investigate the prevalence and genetic characteristics of HRSVs circulating in South Korea, we analyzed medical records of patients and performed molecular analysis of the G-protein gene of viruses detected from nasopharyngeal aspirates (NPA) of admitted patients at the Pediatrics ...
DOI:
10.1007/s00705-012-1267-1
PubMed:
22402914

20. Evaluation of the Efficacy and Cross-Protectivity of Recent Human and Swine Vaccines against the Pandemic (H1N1) 2009 Virus Infection

Author:
Song, Min-Suk,   et al.   ; Pascua, Philippe Noriel Q.; Lee, Jun Han; Park, Kuk Jin; Kwon, Hyeok-il; Baek, Yun Hee; Hong, Seung-Pyo; Rho, Jong-Bok; Kim, Chul-Joong; Poo, Haryoung; Ryoo, Thomas S.; Sung, Moon-Hee; Choi, Young Ki;     Show all 13 Authors
Source:
PloS one 2009 v.4 no.12
ISSN:
1932-6203
Subject:
cross reaction; lungs; humans; antibody formation; viral diseases of animals and humans; vaccines; Influenza A virus; ferrets; viral antigens; mice; vaccination; strains; miniature swine; virus replication; swine
Abstract:
... The current pandemic (H1N1) 2009 virus remains transmissible among humans worldwide with cases of reverse zoonosis, providing opportunities to produce more pathogenic variants which could pose greater human health concerns. To investigate whether recent seasonal human or swine H1N1 vaccines could induce cross-reactive immune responses against infection with the pandemic (H1N1) 2009 virus, mice, fe ...
DOI:
10.1371/journal.pone.0008431
PubMed:
20037716
PubMed Central:
PMC2793524