Jump to Main Content
- Song, Sihong, et al. Show all 2 Author
- Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.40 pp. 17158-17162
- in vivo studies; gene therapy; blood serum; transgenes; immunosuppression; dendritic cells; serotypes; transgenic animals; mice; viruses; immune response; in vitro studies
- ... Recently developed serotypes of recombinant adeno-associated virus (rAAV) vectors have significantly enhanced the use of rAAV vectors for gene therapy. However, host immune responses to the transgene products from different serotypes remain uncharacterized. In the present study, we evaluated the differential immune responses to the transgene products from rAAV1 and rAAV8 vectors. In non-obese diab ...
- PubMed Central:
- Song, Sihong, et al. Show all 10 Authors
- Human gene therapy 2016 v.27 pp. 1-8
- adults; animal models; anti-inflammatory activity; biomarkers; blood serum; bone resorption; bone strength; gene expression; gene therapy; health services; humans; interleukin-6; mice; osteoporosis; ovariectomy; pathogenesis; phosphates; postmenopause; proteins; risk; viruses; women
- ... Osteoporosis is a major healthcare burden affecting mostly postmenopausal women characterized by compromised bone strength and increased risk of fragility fracture. Although pathogenesis of this disease is complex, elevated proinflammatory cytokine production is clearly involved in bone loss at menopause. Therefore, anti-inflammatory strategies hold a great potential for the prevention of postmeno ...
- Song, Sihong, et al. Show all 4 Authors
- Annals of the New York Academy of Sciences 2012 v.1240 pp. 1
- acid phosphatase; anti-inflammatory activity; blood serum; bone marrow; bone resorption; calcitonin; cytokines; estrogens; leptin; mice; osteocalcin; osteoclasts; ovariectomy; phosphates; receptors; tibia; tissue weight; trypsin inhibitors; uterus
- ... Proinflammatory cytokines are primary mediators of bone loss in estrogen deficiency. This study determined whether alpha-1 antitrypsin (AAT), a multifunctional protein with proteinase inhibitor and anti-inflammatory activities, mitigates bone loss induced by estrogen deficiency. Mice were either sham-operated or ovariectomized and injected with either AAT or phosphate buffered saline (PBS). Ovarie ...