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- Speciner, Lauren, et al. Show all 3 Authors
- Journal of Controlled Release 2016 v.240 pp. 544-560
- absorption; bioavailability; digestion; drugs; emulsions; intestinal mucosa; lipid metabolism; lipids; pharmacokinetics; solubility
- ... The majority of newly discovered oral drugs are poorly water soluble, and co-administration with lipids has proven effective in significantly enhancing bioavailability of some compounds with low aqueous solubility. Yet, lipid-based delivery technologies have not been widely employed in commercial oral products. Lipids can impact drug transport and fate in the gastrointestinal (GI) tract through mu ...
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- Speciner, Lauren, et al. Show all 5 Authors
- Biomaterials 2015 v.54 pp. 1-8
- calcium; circulatory system; crosslinking; drugs; endocytosis; gels; histology; ingestion; intestinal mucosa; lectins; lipids; microparticles; mucus; nutrients; pH; staining; viscoelasticity
- ... Orally delivered drugs and nutrients must diffuse through mucus to enter the circulatory system, but the barrier properties of mucus and their modulation by physiological factors are generally poorly characterized. The main objective of this study was to examine the impact of physicochemical changes occurring upon food ingestion on gastrointestinal (GI) mucus barrier properties. Lipids representat ...